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Figure 1: (a-d) Pineocytoma (WHO grade I): (a) Tumor composed of uniform cells in lobules having eosinophilic and clear cytoplasm with calcification (H and E: ×100), (b) diffuse synaptophysin (IHC: ×100), (c) MIB1 labeling <1% (IHC: ×100), and (d) pineocytomatous rosettes (IHC: ×100). (e-h) PPTID (WHO grade II): (e) Tumor in lobules with no mitotic activity (H and E: ×100), (f) diffuse synaptophysin (IHC: ×100), (g) MIB1 LI of 4%–5% (IHC: ×100), and (h) positive NFP (IHC: ×100). (i-l) PPTID (WHO grade III): (i) Tumor in lobules with moderate atypia (H and E: ×100), (j) diffuse synaptophysin (IHC: ×100), (k) MIB1 LI of 12%–15% (IHC: ×200), and (l) negative NFP (IHC: ×200). (m-p) Pineoblatoma (WHO grade IV): (m) Diffuse sheet of embryonal round cell tumor with hyperchromatic nucleus (H and E: ×100), (n) diffuse synaptophysin (IHC: ×100), (o) MIB1 LI of 20%–25% (IHC: ×100), and (p) negative neurofilament protein (IHC: ×100). LI: labeling index; NFP: neurofilament protein; PPTID: pineal parenchymal tumor of intermediate differentiation; H and E: hematoxylin and eosin; IHC: immunohistochemistry; WHO: World Health Organization

Figure 1: (a-d) Pineocytoma (WHO grade I): (a) Tumor composed of uniform cells in lobules having eosinophilic and clear cytoplasm with calcification (H and E: ×100), (b) diffuse synaptophysin (IHC: ×100), (c) MIB1 labeling <1% (IHC: ×100), and (d) pineocytomatous rosettes (IHC: ×100). (e-h) PPTID (WHO grade II): (e) Tumor in lobules with no mitotic activity (H and E: ×100), (f) diffuse synaptophysin (IHC: ×100), (g) MIB1 LI of 4%–5% (IHC: ×100), and (h) positive NFP (IHC: ×100). (i-l) PPTID (WHO grade III): (i) Tumor in lobules with moderate atypia (H and E: ×100), (j) diffuse synaptophysin (IHC: ×100), (k) MIB1 LI of 12%–15% (IHC: ×200), and (l) negative NFP (IHC: ×200). (m-p) Pineoblatoma (WHO grade IV): (m) Diffuse sheet of embryonal round cell tumor with hyperchromatic nucleus (H and E: ×100), (n) diffuse synaptophysin (IHC: ×100), (o) MIB1 LI of 20%–25% (IHC: ×100), and (p) negative neurofilament protein (IHC: ×100). LI: labeling index; NFP: neurofilament protein; PPTID: pineal parenchymal tumor of intermediate differentiation; H and E: hematoxylin and eosin; IHC: immunohistochemistry; WHO: World Health Organization