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Figure 4: (a-f) Papillary tumor of pineal region (WHO grade II). (a and b) Papillary tumor lined by single- to multilayered epithelioid or columnar cells with moderate clear to eosinophilic cytoplasm [H and E: (a) ×200, (b) ×400], (c) Diffuse AE1/AE3 positivity (IHC: ×200), (d) immunonegativity for EMA (IHC: ×400), (e) MIB1 labeling index of 6%–8% (IHC: ×400), (f) focal GFAP positivity (IHC: ×400). AE1/AE3: mouse monoclonal pancytokeratin antibody (AE1/AE3); EMA: epithelial membrane antigen; GFAP: glial fibrillary acidic protein

Figure 4: (a-f) Papillary tumor of pineal region (WHO grade II). (a and b) Papillary tumor lined by single- to multilayered epithelioid or columnar cells with moderate clear to eosinophilic cytoplasm [H and E: (a) ×200, (b) ×400], (c) Diffuse AE1/AE3 positivity (IHC: ×200), (d) immunonegativity for EMA (IHC: ×400), (e) MIB1 labeling index of 6%–8% (IHC: ×400), (f) focal GFAP positivity (IHC: ×400). AE1/AE3: mouse monoclonal pancytokeratin antibody (AE1/AE3); EMA: epithelial membrane antigen; GFAP: glial fibrillary acidic protein