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Figure 1: (a) Heatmap depicting Hierarchical clustering of all samples and genomic regions according to differential methylation profiles, green methylation up (high 5mC), red methylation down (low 5mC) (b) Bar chart showing genomic distribution of CpG sites with altered DNA methylation patterns in patients with HS as compared to the autopsy controls (c) mRNA levels of DNMT1 showing increased expression whereas mRNA levels of DNMT3a remain unaltered Data represent mean ± SEM (n = 14) for HS and (n = 8) for controls, each done in triplicate (P < 0.05)

Figure 1: (a) Heatmap depicting Hierarchical clustering of all samples and genomic regions according to differential methylation profiles, green methylation up (high 5mC), red methylation down (low 5mC) (b) Bar chart showing genomic distribution of CpG sites with altered DNA methylation patterns in patients with HS as compared to the autopsy controls (c) mRNA levels of <i>DNMT1</i> showing increased expression whereas mRNA levels of <i>DNMT3a</i> remain unaltered Data represent mean ± SEM (<i>n</i> = 14) for HS and (<i>n</i> = 8) for controls, each done in triplicate (<i>P</i> < 0.05)