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Figure 2: (a and b) Venn diagram showing total number of hypermethylated/down regulated and hypomethylated/upregulated genes (c) The expression level of upregulated mRNAs (CACNG2, NRP1, TFAP2A, SEMA3B, IGF2BP2) and down regulated mRNAs (ADAM17, IRF6 and MAP3K11) as identified in the RNAseq data were further validated by real-time PCR Data represent mean ± SEM (n = 14) for HS and (n = 8) for controls, each done in triplicate (P < 0.05)

Figure 2: (a and b) Venn diagram showing total number of hypermethylated/down regulated and hypomethylated/upregulated genes (c) The expression level of upregulated mRNAs (<i>CACNG2, NRP1, TFAP2A, SEMA3B, IGF2BP2)</i> and down regulated mRNAs (<i>ADAM17, IRF6</i> and <i>MAP3K11</i>) as identified in the RNAseq data were further validated by real-time PCR Data represent mean ± SEM (<i>n</i> = 14) for HS and (<i>n</i> = 8) for controls, each done in triplicate (<i>P</i> < 0.05)