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Figure 2: Anaplastic astrocytoma. (a) Moderately cellular glial tumor with fibrillated, pleomorphic, and gemistocytic cells in a fibrillary stroma. (b) The loss of normal nuclear expression of ATRX in the tumor cells, indicating ATRX gene mutation. (c) Tumor cells are negative for IDH1-R132H, a proxy marker for IDH1 R132H mutation. (d) Positive staining for p53. (e) High Ki67 (MiB1) proliferation index. (a: HE; b-e: Immunohistochemistry; Original magnification: a-d X200; e: X100)

Figure 2: Anaplastic astrocytoma. (a) Moderately cellular glial tumor with fibrillated, pleomorphic, and gemistocytic cells in a fibrillary stroma. (b) The loss of normal nuclear expression of ATRX in the tumor cells, indicating <i>ATRX</i> gene mutation. (c) Tumor cells are negative for IDH1-R132H, a proxy marker for IDH1 R132H mutation. (d) Positive staining for p53. (e) High Ki67 (MiB1) proliferation index. (a: HE; b-e: Immunohistochemistry; Original magnification: a-d X200; e: X100)