|Year : 1998 | Volume
| Issue : 2 | Page : 102--104
Gabapentin in refractory partial seizures.
M Dhanaraj, CU Velmurugendran
Department of Neurology, Govt. General Hospital, Madras - 600 003, India
We report our preliminary observations on the role of Gabapentin as an add - on therapy in 16 patients with partial or secondary generalised seizures who were resistant to conventional antiepileptic drugs. There was a reduction in the seizure frequency by more than 50 in 11 (69), less than 50 in 3 (18.75), and increase in 1 (6.25). Adverse effects were noted in 9 (56.25 ) of them. The giddiness and sleepiness was seen in 5 (31.25 ); in one it was so severe that he withdrew from the study. Ataxic gait was observed in 1 (6.25). Reduction in the haemoglobin by 2 gms. occurred in 2 (12.5) and asymptomatic eosinophilia in 1 (6.25). As an add - on drug, the efficacy of Gabapentin was good. Regular haematological monitoring is necessary while the patients are on the drug. Further studies involving large number of patients in our country is necessary.
Department of Neurology, Govt. General Hospital, Madras - 600 003
Source of Support: None, Conflict of Interest: None
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