|Year : 2001 | Volume
| Issue : 2 | Page : 144--7
Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.
R Lath, G Chacko, MJ Chandy
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India., India
Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.
Source of Support: None, Conflict of Interest: None
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