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Year : 2001  |  Volume : 49  |  Issue : 2  |  Page : 144--7

Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.


Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India., India

Correspondence Address:
R Lath
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.
India
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Source of Support: None, Conflict of Interest: None


PMID: 11447433

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Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow