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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 51  |  Issue : 3  |  Page : 367--369

Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy


Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow - 226014, India

Correspondence Address:
B Mittal
Department of Medical Genetics, Sanjay Gandhi PGI, Raebareli Road, Lucknow - 226014
India
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Source of Support: None, Conflict of Interest: None


PMID: 14652441

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The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.






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Online since 20th March '04
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