Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 1845  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
   Next article
   Previous article 
   Table of Contents
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (443 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this Article

 Article Access Statistics
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal

Year : 2004  |  Volume : 52  |  Issue : 2  |  Page : 271

Satoyoshi syndrome: Comments

Mayo Clinic , Rochester, MN, USA

Correspondence Address:
Mayo Clinic , Rochester, MN, USA

How to cite this article:
Varkey BM. Satoyoshi syndrome: Comments. Neurol India 2004;52:271

How to cite this URL:
Varkey BM. Satoyoshi syndrome: Comments. Neurol India [serial online] 2004 [cited 2021 Aug 1];52:271. Available from:

I read with interest a case report of Satoyoshi syndrome by Ashalatha et al.[1] The similarity with a 'jerking stiff-man syndrome' -a variant of stiff-man syndrome (SMS) is striking. Distal limb involvement, myoclonic jerking, board-like muscles, stimulus-evoked spasms, endocrinopathies, vitiligo, pernicious anemia and sicca syndrome can also be seen in jerking SMS.[2] Continuous motor unit activity (CMUA) is necessary to diagnose this variant but can sometimes be elusive and manifest only in the paraspinal muscles.[3] Earlier this year, anti-GAD antibodies were described with Satoyoshi syndrome.[4] This validates the auto-immune nature of this disorder and suggests that it might be a variant of stiff-man syndrome. In both cases, a partial response to immunomodulating agents such as immuno-globulin or high dose steroids may be seen. I wonder if anti-GAD antibodies could be tested in the described case as well.

  References Top

1.Ashalatha R, Kishore A, Sarada C, Nair MD. Satayoshi syndrome. Neurol India 2004;52:94-5.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov Disord. 2002;17:853-66.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Brown P, Marsden CD. The stiff man and stiff man plus syndromes.J Neurol. 1999;246:648-52.   Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Drost G, Verrips A, Hooijkaas H, Zwarts M. Glutamic acid decarboxylase antibodies in Satoyoshi syndrome. Ann Neurol. 2004;55:450-1.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]


Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow