Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 80  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Ľ   Next article
 Ľ   Previous article
 Ľ   Table of Contents

 Resource Links
 Ľ   Similar in PUBMED
 Ľ  Search Pubmed for
 Ľ  Search in Google Scholar for
 ĽRelated articles
 Ľ   Citation Manager
 Ľ   Access Statistics
 Ľ   Reader Comments
 Ľ   Email Alert *
 Ľ   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded714    
    Comments [Add]    
    Cited by others 28    

Recommend this journal


Year : 2004  |  Volume : 52  |  Issue : 3  |  Page : 332--337

T2-weighted MRI in Parkinsonís disease; Substantia nigra pars compacta hypointensity correlates with the clinical scores

1 Zonguldak Karaelmas University, Faculty of Medicine Neurology Department, Turkey
2 Ministry of Health Finike State Hospital Neurology Department, Turkey
3 Ministry of Health Ankara Research Hospital, Neurology Department, Turkey
4 Integra MRI Center, Radiology Department, Turkey
5 Zonguldak Karaelmas University Faculty of Medicine Neurology Department, Turkey

Correspondence Address:
Huseyin Tugrul Atasoy
Zonguldak Karaelmas University, Faculty of Medicine, Department of Neurology, Zonguldak - 67700
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 15472421

Rights and PermissionsRights and Permissions

Background: Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinsonís disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. Aims: In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. Methods and Materials: T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinsonís Disease Rating Scale (UPDRS) was used for evaluating the clinical status. Statistical Analyses: Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearmanís rank correlation coefficient for analyses of correlations were used. Results: Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores. Conclusion: The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinsonís disease. The decrease in the intensity of SNpc correlates with poor clinical scores.


Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow