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Year : 2004  |  Volume : 52  |  Issue : 3  |  Page : 383--384

Carcinomatous meningitis mimicking Creutzfeldt-Jakob disease

1 Department of Neurology,Goa Medical College, Bombolim, Goa, India
2 Department of Pathology,Goa Medical College, Bombolim, Goa, India
3 Department of Neuropathology, National Institute of Mental health and Neurosciences, Bangalore, India

Correspondence Address:
S K Shankar
CJD Registry, National Institute of Mental Health and Neurosciences, Bangalore - 560 029
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Source of Support: None, Conflict of Interest: None

PMID: 15472435

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We report a case of carcinomatous meningitis diagnosed at autopsy that was clinically diagnosed as a case of Creutzfeldt-Jakob disease (CJD) because of rapidly evolving dementia. Pathological study revealed diffusely spreading carcinomatous meningitis, infiltrating into cortex along Virchow Robin space. Immunostaining for Prion protein was negative. Despite advances in clinical diagnosis, tissue diagnosis remains a pre-requisite for confirmation of CJD.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow