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Year : 2005  |  Volume : 53  |  Issue : 1  |  Page : 90--92

Protective effects of cisternal irrigation on leptomeningeal and cortical structures in meningitis: An experimental study

1 Departments of Neurosurgery, Ataturk University, Erzurum, Turkey
2 Departments of Pathology, Ataturk University, Erzurum, Turkey
3 Departments of Biochemistry, Ataturk University, Erzurum, Turkey

Correspondence Address:
Mehmet Dumlu Aydin
Department of Neurosurgery, Medical School of Ataturk University, Erzurum
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.15069

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BACKGROUND: Meningitis, termed as foreign material collection in the subarachnoid space, leads to various meningeal, cerebral and spinal cord pathologies. Meningitis still remains a problematic disease with severe complications in spite of advanced medical technology. AIMS: In this study, we aimed to investigate the role of cisternal irrigation in the prevention of meningitis complications. SETTING AND STUDY DESIGN: Experimental study was done in the Social Security Hospital of Erzurum. Histopathological specimens were evaluated in the Pathology Department in the Ataturk University Research Hospital, Erzurum, Turkey. MATERIALS AND METHODS: This study was conducted on twelve lambs. Experimental meningitis was achieved with streptococcus pneumonia. Two animals were not treated. Ten animals were given CefotaximeR (4x1 g/day) for 20 days, and additionally half of these animals underwent cisternal irrigation. Then, all animals were sacrificed and brains were observed histopathologically. RESULTS: Massive purulent CSF formation, hemorrhagic cortical lesions, vascular congestion, leptomeningeal and cortical adhesions and brain edema were observed in the non-irrigated group, but these findings were observed slightly or absent in the irrigated group. CONCLUSION: Meningitis can affect all central neural tissues, consequently serious central nervous system lesions may develop. The irrigation procedure may decrease the percentage and severity of meningitis complications by way of the excretion of inflammed purulent collection from the subarachnoid spaces.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow