| Article Access Statistics | | | Viewed | 5987 | | | Printed | 213 | | | Emailed | 1 | | | PDF Downloaded | 184 | | | Comments | [Add] | | | Cited by others | 12 | | |
|
Click on image for details.
|
|
| CASE REPORT |
|
|
|
| Year : 2006 | Volume
: 54
| Issue : 3 | Page : 306-307 |
An intradural skull base chordoma presenting with acute intratumoral hemorrhage
Takehiro Uda, Kenji Ohata, Toshihiro Takami, Mitsuhiro Hara
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
| Date of Acceptance | 05-Feb-2006 |
Correspondence Address:
Kenji Ohata
Department of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585
Japan
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.27162
We present a rare case of skull base chordoma of extraosseous intradural type that presented as acute intratumoral hemorrhage. Surgical removal of the tumor was accomplished using a skull base approach.
Keywords: Echordosis physaliphora, intradural chordoma, intratumoral hemorrhage
How to cite this article:
Uda T, Ohata K, Takami T, Hara M. An intradural skull base chordoma presenting with acute intratumoral hemorrhage. Neurol India 2006;54:306-7 |
| » Introduction | |  |
Skull base chordomas are in general extradural tumors and present with slow progressive symptoms over several months. We report a case of skull base chordoma that was intradural in location and presented with acute intratumoral hemorrhage.
| » Case Report | | |
A 35-year-old woman suffered a sudden episode of headache and right hemibody hyperalgesia. Investigations showed a hemorrhagic tumor extending intradurally on CT and a contiguous relationship between the tumor and the dural wall of the clivus on enhanced T1-weighted sagittal images [Figure - 1]. No destructive alteration of the clivus was detected on serial high-resolution CT.
A transcondylar approach revealed a gelatinous tumor covered by thickened arachnoid membrane. Internal debulking of the tumor was first accomplished via the space between the 9th and 10th nerve complex and the 7th and 8th nerve complex [Figure - 2]. The tumor appeared to grow invasively into the brainstem. Tumor removal revealed dural attachment of the tumor at the clivus. The tumor was totally intradural and the bony structure of the petroclival area was intact. Subtotal removal of the tumor was accomplished and residual tumor tissue remained in relationship to the brainstem and the dural layer of the clivus. Pathological examination of tumor tissue showed a lobular pattern of physaliphorous cells with abundantly vacuolated cytoplasm [Figure - 3]. Histological examination of the tumor revealed typical features of a chordoma.
Postoperatively the patient was noted to have worsened in consciousness. Postoperative CT scanning revealed the localized hemorrhage in the tumor cavity. Emergency surgery for removal of the hematoma was performed. The second surgery suggested that postoperative hemorrhage was localized in the tumor cavity and was caused by the bleeding from the residual tumor. Three months after surgery, the neurological status of the patient had further improved and she was able to carry on normal activities with some effort. Postoperative MR images, obtained at 3 months after surgery, indicated a small residual tumor [Figure - 1]B. At a six-month follow-up scan, growth of the residual tumor was identified. Adjuvant treatment of stereotactic radiosurgery was administered.
| » Discussion | | |
Patients with skull base chordomas generally present with progressive clinical symptoms. We identified 11 documented cases, from the literature, of skull base chordomas presenting with acute intratumoral or intracranial hemorrhage [Table - 1]. Numerous mechanisms have been proposed to explain the etiology of intratumoral or intracranial hemorrhage in conjunction with brain tumors.[1],[2] The growth pattern of skull base chordomas suggests that extraosseous intradural chordomas are different from the classic type. Extraosseous intradural chordomas are hypothesized to originate from the ecchordosis physaliphora.[3] Preoperatively, we did not consider that this hemorrhagic tumor was extraosseous intradural chordoma; therefore, we selected the transcondylar approach. However, for radical resection of a chordoma of this region, extended middle fossa approach described by Goel may have been ideal .[4] Adjuvant therapy after subtotal resection of the skull base chordoma may be indispensable. Conventional radiation therapy, stereotactic radiosurgery and proton beam therapy are alternatives.
| » References | | |
| 1. | Franquemont DW, Katsetos CD, Ross GW. Fatal acute pontocerebellar hemorrhage due to an unsuspected spheno-occipital chordoma. Arch Pathol Lab Med 1989;113:1075-8.  [PUBMED] [FULLTEXT] |
| 2. | Levi AD, Kucharczyk W, Lang AP, Schutz H. Clival chordoma presenting with acute brain stem hemorrhage. Can J Neurol Sci 1991;18:515-8. [PUBMED] [FULLTEXT] |
| 3. | Mehnert F, Beschorner R, Kuker W, Hahn U, Nagele T. Retroclival ecchordosis physaliphora: MR imaging and review of the literature. AJNR Am J Neuroradiol 2004;25:1851-5. [PUBMED] [FULLTEXT] |
| 4. | Goel A. Extended middle fossa approach for petroclival lesions. Acta Neurochir (Wien) 1995;135:78-83. [PUBMED] [FULLTEXT] |
Figures
[Figure - 1], [Figure - 2], [Figure - 3] Tables
[Table - 1]
| This article has been cited by | | 1 |
Intrasellar hemorrhagic chordoma masquerading as pituitary apoplexy: case report and review of the literature |
|
| Boyi Li, Michael G. Kim, Jose F. Dominguez, Eric Feldstein, George Kleinman, Fawaz Al-Mufti, Matthew Kim, Simon Hanft | | British Journal of Neurosurgery. 2021; : 1 | | [Pubmed] | [DOI] | | | 2 |
Hemorrhagic Skull Base Chordoma Presenting As Chordoma Apoplexy |
|
| Ece Uysal, Michael A Cohen, Hussam Abou-Al-Shaar, Cheryl Palmer, William Couldwell | | Cureus. 2021; | | [Pubmed] | [DOI] | | | 3 |
Chordoma of the corpus callosum: case report |
|
| Lorenzo Rinaldo, David S. Priemer, Alexander O. Vortmeyer, Aaron A. Cohen-Gadol, Daniel J. Brat, Anita Mahajan, Caterina Giannini, Terry C. Burns | | Journal of Neurosurgery. 2019; 131(5): 1380 | | [Pubmed] | [DOI] | | | 4 |
Intradural cervical chordoma with diffuse spinal leptomeningeal spread: case report and review of the literature |
|
| Jing Zhang,Chuan-ping Gao,Xue-jun Liu,Wen-Jian Xu | | European Spine Journal. 2018; | | [Pubmed] | [DOI] | | | 5 |
A Hemorrhagic Clival Chordoma with a Long Progression-Free Survival |
|
| Marcelo D. Vilela,Hugo A.S. Pedrosa,Marco Antonio Dias Filho | | World Neurosurgery. 2017; 105: 1042.e1 | | [Pubmed] | [DOI] | | | 6 |
Intradural chordoma presenting with intratumoral bleeding |
|
| Eduardo de Arnaldo Silva Vellutini,Matheus Fernandes de Oliveira | | Journal of Clinical Neuroscience. 2016; 25: 139 | | [Pubmed] | [DOI] | | | 7 |
Skull Base Chondroid Chordoma: Atypical Case Manifesting as Intratumoral Hemorrhage and Literature Review |
|
| Satoshi Tsutsumi,Chihiro Akiba,Takamoto Suzuki,Hajime Nakanishi,Hiroshi Izumi,Yukimasa Yasumoto,Masanori Ito | | Clinical Neuroradiology. 2014; 24(4): 313 | | [Pubmed] | [DOI] | | | 8 |
Intracranial intradural chordoma presenting with intraventricular hemorrhage |
|
| Sung Kwon Kim,Yong Hwy Kim,Chul-Kee Park,Min A. Kim,Sung Hye Park | | Clinical Neurology and Neurosurgery. 2012; 114(8): 1189 | | [Pubmed] | [DOI] | | | 9 |
Intracranial intradural chordoma presenting with intraventricular hemorrhage |
|
| Kim, S.K. and Kim, Y.H. and Park, C.-K. and Kim, M.A. and Park, S.H. | | Clinical Neurology and Neurosurgery. 2012; 114(8): 1189-1192 | | [Pubmed] | | | 10 |
Treatment of chordoma with imatinib complicated by intracranial hemorrhage: a case showing dissociation between biological effect and therapeutic outcome |
|
| François Mercier, Marie-Christine Guiot, Michel W. Bojanowski | | Journal of Neuro-Oncology. 2011; | | [VIEW] | [DOI] | | | 11 |
Intradural drop metastasis of a clival chordoma |
|
| Martin, M.P., Olson, S. | | Journal of Clinical Neuroscience. 2009; 16(8): 1105-1107 | | [Pubmed] | | | 12 |
Intradural drop metastasis of a clival chordoma |
|
| Michael Patrick Martin,Sarah Olson | | Journal of Clinical Neuroscience. 2009; 16(8): 1105 | | [Pubmed] | [DOI] | |
|
|
|
|
|
|
|
|
