Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 1515  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded319    
    Comments [Add]    
    Cited by others 12    

Recommend this journal


Year : 2009  |  Volume : 57  |  Issue : 2  |  Page : 143--150

Hyperdense middle cerebral artery sign in multidetector computed tomography: Definition, occurrence, and reliability analysis

1 Faculty of Medicine, Section of Neuroradiology, Department of Radiology, University of Lund, Malmö University Hospital, Malmö, Sweden
2 Faculty of Medicine, Section of Neuroradiology, Department of Neurology, University of Lund, Malmö University Hospital, Malmö, Sweden

Correspondence Address:
Kasim Abul-Kasim
Faculty of Medicine, University of Lund, Department of Radiology, Section of Neuroradiology, Malmö University Hospital, 205 02 Malmö
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.51282

Rights and Permissions

Background: The hyperdense middle cerebral artery sign (HMCAS) is one of the early changes seen on the computed tomography in acute ischemic stroke of MCA territory. Aims: To evaluate the reliability of subjective evaluation of HMCAS on CT performed at multidetector CT (MDCT) and evaluated in the Picture Archiving Communication Systems, to define objective criteria for HMCAS and to find out if there are any predictors for the occurrence of HMCAS. Materials and Methods: CTs of 121 consecutive patients (mean age of 70 years) treated with thrombolytic therapy were retrospectively evaluated by two neuroradiologists both subjectively and objectively with respect to HMCAS. Results: HMCAS was subjectively found in 32% of study population. The interobserver and intraobserver agreement were substantial (K value of 0.69 and 0.80, respectively) and increased to almost perfect (Kvalue of 0.86) when the reader provided with clinical information. The HMCAS was found twice as often in male patients. Patients with HMCAS were three years younger than those whose baseline CT did not show HMCAS. A 100% sensitivity achieved when objective criteria were defined as combination of MCA attenuation ≥ 46HU and MCA ratio > 1.2 (using oval ROIs) and MCA attenuation ≥ 50 HU and MCA ratio of > 1.4 (using pixel sized ROIs). Conclusion: Performing CT examinations on MDCT and assessment of the images in PACS might have contributed to improvement of the reliability of evaluating HMCAS on CT by enabling an objective evaluation of this sign with measurements of attenuation value in the course of MCA using oval or pixel sized ROIs as well as estimation of MCA ratio .


Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow