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Year : 2009  |  Volume : 57  |  Issue : 6  |  Page : 837

Imaging for diagnosis of Marchiafava-Bignami disease

Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Date of Acceptance15-Dec-2009
Date of Web Publication30-Jan-2010

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok - 10160
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.59505

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How to cite this article:
Wiwanitkit V. Imaging for diagnosis of Marchiafava-Bignami disease. Neurol India 2009;57:837

How to cite this URL:
Wiwanitkit V. Imaging for diagnosis of Marchiafava-Bignami disease. Neurol India [serial online] 2009 [cited 2023 Nov 30];57:837. Available from:


I read the two recent publications on imaging for the diagnosis of Marchiafava-Bignami disease (MBD) with great interest. [1],[2] Both the reports showed success in the use of high technology neuro imaging in the diagnosis of MBD. However, whether the new imaging approach is an actually good diagnostic approach for MBD is still questionable. The sensitivity and specificity of the test has to be assessed. Indeed, due to the nature of imaging technology, not a pathological examination, the definitive diagnosis cannot be expected. Indeed, the difference in the details of imaging findings in both the reports can be seen and can be a good supportive evidence for this argument.[1],[2] Second, the MBD is an extremely rare disease, using of imaging technology as a screening cannot be cost effective at all. The use of good clinical practice, good history taking and physical examination, might provide similar outcome of case management since most cases of MBD are usually suspected at rather late stages.

 » References Top

1.Bano S, Mehra S, Yadav SN, Chaudhary V. Marchiafava-Bignami disease: Role of neuroimaging in the diagnosis and management of acute disease. Neurol India 2009;57:649-52.  Back to cited text no. 1  [PUBMED]  Medknow Journal  
2.Nalini A, Kovoor JM, Dawn R, Kallur KG. Marchiafava-Bignami disease: Two cases with magnetic resonance imaging and positron emission tomography scan findings. Neurol India 2009;57:644-8.  Back to cited text no. 2  [PUBMED]  Medknow Journal  

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1 Diverse MRI findings and clinical outcomes of acute Marchiafava-Bignami disease
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[Pubmed] | [DOI]


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Online since 20th March '04
Published by Wolters Kluwer - Medknow