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Year : 2010  |  Volume : 58  |  Issue : 3  |  Page : 443--445

Apolipoprotein-E genotypes and myasthenia gravis

1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Neurobiochemistry, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Madhuri Behari
Room No (702), Department of Neurology, All India Institute of Medical Sciences, New Delhi
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Source of Support: Indian Council of Medical Research (ICMR), New Delhi, India., Conflict of Interest: None

DOI: 10.4103/0028-3886.65533

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Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG. Anti-AChR antibody was measured using radio receptor immunoassay. Apo-E genotypes were analyzed in 120 MG patients and 120 healthy subjects. Comparison between patients with MG and controls showed no significant association with Apo-E allelic variants. However, a significant association of Apo-E4 allele with AChR-antibody positive patients was observed (P = 0.007). Also, among seropositive patients, a significant association was seen between female gender and Apo-E4 allele (P = 0.023). Our results suggest that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow