Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 5930  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
   Next article
   Previous article 
   Table of Contents
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (470 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this Article
   Article Figures

 Article Access Statistics
    PDF Downloaded105    
    Comments [Add]    

Recommend this journal


Year : 2010  |  Volume : 58  |  Issue : 3  |  Page : 501-502

Florid leptomeningeal dissemination in a case of glioblastoma multiforme

Neurosurgical Services, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India

Date of Acceptance30-Nov-2009
Date of Web Publication17-Jul-2010

Correspondence Address:
Aliasgar V Moiyadi
Tata Memorial Hospital, R. No 48, Main Bldg., Dr. E. Borges Road, Parel, Mumbai -4 00 012
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.65532

Rights and Permissions

How to cite this article:
Shetty PM, Moiyadi AV. Florid leptomeningeal dissemination in a case of glioblastoma multiforme. Neurol India 2010;58:501-2

How to cite this URL:
Shetty PM, Moiyadi AV. Florid leptomeningeal dissemination in a case of glioblastoma multiforme. Neurol India [serial online] 2010 [cited 2021 Dec 8];58:501-2. Available from:

A 40-year-old male presented with a large right temporal swelling. He had undergone a right temporo-parietal craniectomy and biopsy for a temporo-parietal glioblastoma multiforme at an other facility and was advised radiotherapy, but had defaulted. Six months later he presented to us with a progressive lesion growing out of the cranial cavity. He had no neurological deficits despite the large recurrence. The magnetic resonance imaging (MRI) scan of the brain revealed a large tumor mass arising in the right temporo-parietal region with extension extra-cranially through the craniectomy defect. The lesion showed necrotic areas with inhomogeneous contrast enhancement. There was widespread meningeal enhancement seen along the brainstem, cerebellum, cervical cord, cerebral convexity and basal cisterns [Figure 1]a-d. Ependymal enhancement was also seen in the right lateral ventricle [Figure 1]c. The tumor was hyperperfused and had a spectral pattern consistent with glioblastoma multiforme. Debulking surgery was undertaken to facilitate the use of radiotherapy. However, extreme vascularity of the tumor and massive blood loss limited a radical resection. Histology revealed a classical glioblastoma. Patient developed hemi-paresis postoperatively and was referred for radiotherapy subsequently.

Glioblastoma is the commonest primary malignant brain tumor in adults and most often spreads by local infiltration. Leptomeningeal spread through cerebrospinal fluid pathways as seen in primitive neuro-ectodermal tumors, ependymal tumors and germ cell tumors is rare in glioblastomas. The incidence of microscopic leptomeningeal spread in gliomas is reported as high as 30% at autopsy. However, most patients are asymptomatic. [1] and clinically significant leptomeningeal disease has been reported in only 1.55-4% of cases. [2] Few cases of leptomeningeal disease at initial presentation have been described, the majority being detected during treatment or at recurrence. Young age (usually less than 40 years), [3] incompletely excised or biopsied tumors (as in our case), and violation of the ependymal lining during surgery [4] are some of the risk factors associated with leptomeningeal spread. Leptomeningeal spread is associated with poor prognosis, with an average survival of 2.5 months after the diagnosis. [3]

  References Top

1.Onda K, Tanaka R, Takahashi H, Takeda N, Ikuta F. Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy. Neurosurgery 1989;25:533-40.  Back to cited text no. 1  [PUBMED]    
2.Awad I, Bay JW, Rogers L. Leptomeningeal metastasis from supratentorial malignant gliomas. Neurosurgery 1986;19:247-51.  Back to cited text no. 2  [PUBMED]    
3.Tae-Young Jung, Shin Jung, In-Young Kim, Sam-Suk Kang, Soo-Han Kim .High-grade Gliomas: neuraxis dissemination Pattern and prognosis. Neurosurg Q 2007;17:151-5.  Back to cited text no. 3      
4.Grabb PA, Albright AL, Pang D. Dissemination of supratentorial malignant gliomas via the cerebrospinal fluid in children. Neurosurgery 1992;30:64-71.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]  


  [Figure 1]


Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow