Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 10049  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
  » Next article
  » Previous article 
  » Table of Contents
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
  »  Article in PDF (267 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

  In this Article
 »  References

 Article Access Statistics
    PDF Downloaded189    
    Comments [Add]    
    Cited by others 18    

Recommend this journal


Year : 2010  |  Volume : 58  |  Issue : 4  |  Page : 598-599

Dengue myositis and myocarditis

Department of Medicine, Byramjee Jeejeebhoy Medical College, Pune - 411 001, India

Date of Acceptance17-Jul-2010
Date of Web Publication24-Aug-2010

Correspondence Address:
Shashikala A Sangle
Department of Medicine, Byramjee Jeejeebhoy Medical College, Pune - 411 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.68664

Rights and Permissions

How to cite this article:
Sangle SA, Dasgupta A, Ratnalikar SD, Kulkarni RV. Dengue myositis and myocarditis. Neurol India 2010;58:598-9

How to cite this URL:
Sangle SA, Dasgupta A, Ratnalikar SD, Kulkarni RV. Dengue myositis and myocarditis. Neurol India [serial online] 2010 [cited 2023 Feb 4];58:598-9. Available from: https://www.neurologyindia.com/text.asp?2010/58/4/598/68664


Dengue is a common viral infection in the tropics. Neurological complications of dengue fever are being increasingly recognized in the recent years. Dengue commonly presents with a varying degree of myalgia; however, muscle weakness is distinctly uncommon. A few cases of myositis [1],[2] and even rhabdomyolysis [3],[4] have been reported. Muscle involvement can be histopathological. [5] Myocarditis has also been reported in dengue fever. [6],[7],[8] We report a case of dengue shock syndrome with myositis and myocarditis.

A 16-year-old girl presented with moderate-grade fever with severe malaise and myalgia. Around day 3, she developed a reddish rash over her abdomen that rapidly spread to involve the limbs. She also reported bleeding from her gums while brushing. On admission (day 7 of fever), she was found to be febrile, 38.3ΊC, pulse rate 116/min and blood pressure 90/70 mmHg. She had subconjunctival hemorrhages bilaterally and confluent, reddish macules all over her trunk and limbs. Muscles were tender. Neurological examination did not reveal any deficits. All other systems were clinically normal. Laboratory investigations showed hemoglobin of 14 g%, hematocrit of 43%, platelet count of 80,000/mm 3 and blunting of both costophrenic angles bilaterally on the chest X-ray. Dengue serology: IgM titers were elevated (day 9) with normal IgG titers.

Hemodynamic stability was achieved with intravenous fluid resuscitation. However, she was found to have persistent resting tachycardia. The electrocardiogram showed sinus tachycardia with low-voltage complexes in all leads. A 2D-echocardiogram performed on day 3 of hospitalization showed poor septal motion, left ventricular internal diameter-diastolic [LVID-(D)] = 50 mm, left ventricular internal diameter-systolic [LVID-(S)] = 30 mm. There was a thin pericardial effusion. Creatine phosphokinase-MB (CPK-MB) was 92 IU/L (normal -0-50 IU/L).

On day 3 (day 10 of symptoms onset), she was found to have difficulty in getting up from squatting position. Neurological examination revealed hypotonia and proximal muscles weakness in both upper and lower limbs. Her trunk muscles were also weak. Sensory system was normal with normal deep tendon reflexes and plantar response. Muscles were tender. Weakness progressed over the next few days and the patient developed neck muscle weakness and dysphagia. Her gag reflex was sluggish, necessitating the placement of a nasogastric tube.

Laboratory data: serum SGOT 120 IU/L, serum CPK 310 1U/L and normal serum electrolytes. Urine for myoglobin was negative. Electrodiagnostic evaluation showed normal motor and sensory conduction and electromyogram (EMG) showed small-amplitude polyphasic potentials with a normal interference pattern, suggestive of myopathy. However, there was no abnormal insertional or spontaneous activity. Muscle biopsy was essentially normal. Magnetic resonance imaging (MRI) of the brain was also normal.

The patient was treated symptomatically and physiotherapy was introduced gradually. She made a gradual recovery and was discharged after 1 month of hospitalization. At the time of discharge, her neurological evaluation was essentially normal. At discharge, her laboratory values were: Hb 12.2 g%; hematocrit 37%; platelet count 2.5 lakh/mm 3 ; SGOT 22 IU/L; CPK 135 IU/L. ECG was normal and 2D-echocardiographic findings were LVID-(D) 42 mm and LVID-(S) 20 mm.

Dengue can cause acute pure motor quadriplegia [1],[2] and even rhabdomyolysis. [3],[4] In the series by Kalita et al., [1] CPK was elevated in all the seven patients; one patient had myopathic features on EMG and in one muscle biopsy was suggestive of myositis. Malheiros et al. [5] reported muscle biopsy findings in 15 patients with dengue fever and myalgia without any weakness: mild to moderate perivascular mononuclear infiltrates in 12 patients and lipid accumulation in 11 patients. Muscle biopsy in our case was normal.

Myocarditis has also been reported in dengue fever. [6],[7] Wali et al. [6] reported a patient with dengue hemorrhagic fever/dengue shock syndrome with transient cardiac involvement with poor left ventricular ejection fraction. Cardiac involvement in this patient had worsened the hypotension and shock. Arrhythmias involving sinus node dysfunction have also been reported. [7] Recently, Salgado et al. [8] have demonstrated infection of heart tissues in vivo and striated skeletal cells in vitro. It has been proposed that the derangements of Ca 2+ storage in the infected cells may directly contribute to the presentation of myocarditis.

We conclude that acute, flaccid quadriparesis with tender muscles signifying myositis and myocarditis may be novel complications of dengue fever. One must be vigilant for these complications as they may lead to potentially disastrous consequences like respiratory failure, rhabdomyolysis, aspiration pneumonia and heart failure.

 » References Top

1.Kalita J, Misra UK, Mahadevan A, Shankar SK. Acute pure motor quadriplegia: is it dengue myositis? Electromyogr Clin Neurophysiol 2005;45:357-61.  Back to cited text no. 1  [PUBMED]    
2.Ahmad R, Abdul Latiff AK, Abdul Razak S. Myalgia Cruris Epidemica: an unusual presentation of dengue fever. Southeast Asian J Trop Med Public Health. 2007;38:1084-87.  Back to cited text no. 2  [PUBMED]    
3.Lim M, Goh HK. Rhabdomyolysis following dengue virus infection. Singapore Med J 2005;46:645-6.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Davis JS, Bourke P. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 2004;38:109-11.  Back to cited text no. 4      
5.Malheiros SM, Oliveira AS, Schmidt B, Lima JG, Gabbai AA. Dengue. Muscle biopsy findings in 15 patients. Arq Neuropsiquiatr 1993;51:159-64.  Back to cited text no. 5  [PUBMED]    
6.Wali JP, Biswas A, Chandra S, Malhotra A, Aggarwal P, Handa R, et al. Cardiac involvement in dengue haemorrhagic fever. Int J Cardiol 1998;64:31-6.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]  
7.Promphan W, Sopontammarak S, Pruekprasert P, Kajornwattanakul W, Kongpattanayothin A. Dengue myocarditis. Southeast Asian J Trop Med Public Health 2004;35:611-3.  Back to cited text no. 7  [PUBMED]    
8.Salgado DM, Eltit JM, Mansfield K, Panqueba C, Castro D, Vega MR, et al. Heart and skeletal muscle are targets of dengue virus infection. Pediatric Infect Dis J 2010;29:238-42.  Back to cited text no. 8      

This article has been cited by
1 Neurological Complications of Dengue Fever
Sweety Trivedi, Ambar Chakravarty
Current Neurology and Neuroscience Reports. 2022;
[Pubmed] | [DOI]
2 Changing spectrum of acute encephalitis syndrome in India and a syndromic approach
UshaK Misra, Jayantee Kalita
Annals of Indian Academy of Neurology. 2022; 25(3): 354
[Pubmed] | [DOI]
3 Dengue hemorrhagic fever and cardiac involvement
Wattana Leowattana, Tawithep Leowattana
World Journal of Meta-Analysis. 2021; 9(3): 286
[Pubmed] | [DOI]
4 Myocarditis occurrence with cancer immunotherapy across indications in clinical trial and post-marketing data
Tigran Makunts, Ila M. Saunders, Isaac V. Cohen, Mengxing Li, Talar Moumedjian, Masara A. Issa, Keith Burkhart, Peter Lee, Sandip Pravin Patel, Ruben Abagyan
Scientific Reports. 2021; 11(1)
[Pubmed] | [DOI]
5 Neurological Manifestations of Dengue Infection
Guo-Hong Li,Zhi-Jie Ning,Yi-Ming Liu,Xiao-Hong Li
Frontiers in Cellular and Infection Microbiology. 2017; 7
[Pubmed] | [DOI]
6 Central nervous system and muscle involvement in dengue patients: A study from a tertiary care center
Usha Kant Misra,Jayantee Kalita,Vinita Elizabeth Mani,Prashant Singh Chauhan,Pankaj Kumar
Journal of Clinical Virology. 2015; 72: 146
[Pubmed] | [DOI]
7 Neurological complications of dengue virus infection
Francisco Javier Carod-Artal,Ole Wichmann,Jeremy Farrar,Joaquim Gascón
The Lancet Neurology. 2013; 12(9): 906
[Pubmed] | [DOI]
8 Unique Neurological Manifestations of Dengue Virus in Pediatric Population: a Case Series
M. Samanta,C. K. Kundu,G. Guha,S. Chatterjee
Journal of Tropical Pediatrics. 2012; 58(5): 398
[Pubmed] | [DOI]
9 Quantitative Electromyography in Dengue-Associated Muscle Dysfunction
Jayantee Kalita,Usha K. Misra,Pradeep K. Maurya,Surala K. Shankar,Anita Mahadevan
Journal of Clinical Neurophysiology. 2012; 29(5): 468
[Pubmed] | [DOI]
10 Dengue-associated transient muscle dysfunction: clinical, electromyography and histopathological changes
U. K. Misra,J. Kalita,P. K. Maurya,P. Kumar,S. K. Shankar,A. Mahadevan
Infection. 2012; 40(2): 125
[Pubmed] | [DOI]
11 Unique neurological manifestations of dengue virus in pediatric population: A case series
Samanta, M. and Kundu, C.K. and Guha, G. and Chatterjee, S.
Journal of Tropical Pediatrics. 2012; 58(5): 398-401
12 Quantitative electromyography in dengue-associated muscle dysfunction
Kalita, J. and Misra, U.K. and Maurya, P.K. and Shankar, S.K. and Mahadevan, A.
Journal of Clinical Neurophysiology. 2012; 29(5): 468-471
13 Dengue-associated transient muscle dysfunction: Clinical, electromyography and histopathological changes
Misra, U.K. and Kalita, J. and Maurya, P.K. and Kumar, P. and Shankar, S.K. and Mahadevan, A.
Infection. 2012; 40(2): 125-130
14 Dengue encephalitis associated with hydrocephalus: A case report
Kamble, R.B. and Venkataramana, N.K. and Raghunath, C.N.
Neuroradiology Journal. 2011; 24(6): 833-837
15 Spectrum of acute dengue virus myositis
Garg, R.K., Paliwal, V.K.
Journal of the Neurological Sciences. 2011; 307(1-2): 180-181
16 Spectrum of acute dengue virus myositis
Ravindra Kumar Garg,Vimal Kumar Paliwal
Journal of the Neurological Sciences. 2011; 307(1-2): 180
[Pubmed] | [DOI]
17 Dengue Encephalitis Associated with Hydrocephalus
R.B. Kamble,N.K. Venkataramana,C.N. Raghunath
The Neuroradiology Journal. 2011; 24(6): 833
[Pubmed] | [DOI]
18 Neurological complication of dengue infection
Murthy, J.M.K.
Neurology India. 2010; 58(4): 581-584


Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow