| CASE REPORT |
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| Year : 2010 | Volume
: 58
| Issue : 5 | Page : 778--780 |
Malignant prolactinoma: A rare case report
Priti Trivedi1, Anuja Gupta1, Sunil Pasricha1, Dipak Patel2
1 Department of Pathology, Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), Ahmedabad, Gujarat, India
2 Department of Neurosurgery, Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), Ahmedabad, Gujarat, India
Correspondence Address:
Priti Trivedi
Room #412, Department of Pathology, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, Gujarat
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.72205
Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describe clinico-pathological and immunohistological features of malignant prolactinoma. The patient initially presented with a prolactin-secreting pituitary adenoma. The tumor showed aggressive clinical course presenting with repeated recurrences and eventually metastasized to multiple bones. MIB-1 and p53 labeling indices were also compared in primary adenoma, recurrent invasive adenoma and metastatic tumor.
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