| CASE REPORT |
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| Year : 2011 | Volume
: 59
| Issue : 1 | Page : 104--107 |
Metronidazole neurotoxicity: Sequential neuroaxis involvement
Kyung-Il Park, Jae-Myun Chung, Ji-Young Kim
Department of Neurology, Seoul Paik Hospital, Inje University College of Medicine, Jur-dong, Chung-ku, Seoul, Korea
Correspondence Address:
Kyung-Il Park
Department of Neurology, Inje University College of Medicine, Seoul Paik Hospital, 85,2-ka, Jur-dong, Chung-ku, Seoul, 100-032
Korea
 Source of Support: Inje University Research Grant (2009), Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.76882
Neurological manifestation of metronidazole toxicity include neuropathy and encephalopathy. We report a 67-year-old man with progressive painful paresthesias involving all the four limbs of 3 weeks' duration before admission. He had been treated with metronidazole and cephalosporin for 10 weeks for a hepatic abscess. Five weeks after the symptom onset, he complained of dysarthria and limb ataxia. Magnetic resonance imaging revealed signal abnormalities in the splenium of the corpus callosum and bilateral dentate nuclei. A few hours after brain imaging, the patient exhibited excessive diaphoresis and fluctuation in blood pressure, which resolved within several hours after discontinuation of metronidazole. Whereas his speech returned to near normal within approximately 1 week, a burning sensation was not completely relieved, even 6 months after discharge.
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