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Year : 2011  |  Volume : 59  |  Issue : 4  |  Page : 513--520

Immunohistochemical differentiation of inflammatory myopathies

1 Section of Neuropathology, Department of Neurological Sciences and Pathology, Christian Medical College, Vellore, India
2 Section of Neurology, Department of Neurological Sciences, Christian Medical College, Vellore, India
3 Section of Neurology, Department of Community Health, Christian Medical College, Vellore, India

Correspondence Address:
Geeta Chacko
Section of Neuropathology, Department of Neurological Sciences and Pathology, Christian Medical College, Vellore - 632 004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.84329

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Background: Idiopathic inflammatory myopathies are a heterogeneous group of acquired muscle disorders with considerable overlap in the histological features, making histological diagnosis difficult at times. Aims: To determine the immunohistochemical profile of clinically suspected cases of inflammatory myopathies, using monoclonal antibodies to HLA-1 and membrane attack complex (MAC), and to correlate the clinical, serological, and electromyographic profile and the histopathological picture, with the immunohistochemical profile. Settings and Design: This was a retrospective study analyzing the clinical and histopathological features in muscle of clinically suspected cases of inflammatory myopathy and correlating it to their HLA-1 and MAC immunostaining profiles. Material and Methods: The study subjects included 33 cases with suspected inflammatory myopathy and 59 with non-inflammatory muscle disease, as controls. Clinical data, electromyographic findings, serological profile, and details of therapy were obtained from patient records. Statistical Analysis: Student 'T' test, Pearson's Chi square test, and Kappa statistics were used appropriately. Results: Although HLA-1 and MAC immunostaining did not help to differentiate the individual subtypes of inflammatory myopathy, when either HLA-1 or MAC was positive, inflammatory myopathy could be ruled in with 86.5% certainty and when both HLA-1 and MAC were negative, it could be ruled out with 95% certainty. Conclusions: A combination of clinical presentation, serological profile, electromyographic and histopathological features, together with the immunoprofile for HLA-1 and MAC, contribute toward making a diagnosis of inflammatory myopathy.


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Online since 20th March '04
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