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 ORIGINAL ARTICLE
Year : 2011  |  Volume : 59  |  Issue : 4  |  Page : 521--526

Association of atherosclerotic cerebral infarction and human leukocyte antigen-DRB in a North Chinese Han population


1 Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China
2 The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China
3 Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, China
4 Class of 2014, Bates College, Lewiston, ME, USA

Correspondence Address:
Xue-Mei Han
Department of Neurology, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun, Jilin 130033
China
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Source of Support: Jilin Provincial Science & Technology Department (200505169), Conflict of Interest: None


DOI: 10.4103/0028-3886.84330

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Background and Objectives: Evidence from experimental and genetic studies suggest the existence of a potential link between the polymorphisms of human leukocyte antigen class II gene (HLA-DR) and ischemic stroke. This study addressed the association of HLA-DR gene with atherosclerotic cerebral infarction (ACI) in a North Chinese Han population. Material and Methods: The genotyping of HLA-DRB1 was determined by standard techniques based on polymerase chain reaction and sequence-specific oligonucleotides hybridization in a gene chip. Results: The relative risk (RR) of HLA-DRB1 * 04 and HLA-DRB1 * 03 (17) in patients with ACI and their first-degree relatives were significantly higher than those in the control group (RR=2.56 and 18.77, respectively; P <0.05). In contrast, the RR of HLA-DRB1 * 12 was dramatically reduced in patients with ACI in relation to healthy controls (RR=0.17; P <0.01). Conclusions: These data indicate that the polymorphisms in HLA-DRB1 may influence the risk of ACI in the North Han population of China. Further studies are necessary to validate the observation in larger samples.






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