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Year : 2012  |  Volume : 60  |  Issue : 1  |  Page : 3--8

Genetics of intracerebral hemorrhage: Insights from candidate gene approaches

Department of Neurology, Xiangya Hospital, Central South University, China

Correspondence Address:
Qidong Yang
Department of Neurology, Xiangya Hospital, Central South University
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Source of Support: National Natural Science Foundation of China (Grant Numbers 30600199)., Conflict of Interest: None

DOI: 10.4103/0028-3886.93581

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Intracerebral hemorrhage (ICH) is a heterogeneous disease with genetic factors playing an important role. Association studies on a wide range of candidate pathways suggest a weak but significant effect for several alleles with ICH risk. Among the most widely investigated genes are those involved in the renin-angiotensin-aldosterone system (e.g., angiotensin-converting enzyme), coagulation pathway (e.g., Factor XIII, Factor VII, platelet-activating factor acetylhydrolase, Factor V Leiden, and beta1-tubulin), lipid metabolism (e.g., apolipoproteins (Apo)E, Apo(a), ApoH), homocysteine metabolism (e.g., methylenetetrahydrofolate reductase), inflammation (e.g., interleukin-6 and tumor necrosis-alpha) and other candidate pathways. To identify the robustness of the above associations with ICH, a search of Pubmed (1988 through December 2011) was performed, with searches limited to English-language studies conducted among adult human subjects. This article presents a review of the examined literature on the genetics of ICH.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow