Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 9397  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (928 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this Article
   Article Figures

 Article Access Statistics
    PDF Downloaded79    
    Comments [Add]    
    Cited by others 2    

Recommend this journal


Table of Contents    
Year : 2012  |  Volume : 60  |  Issue : 6  |  Page : 684-685

Mirror image subependymoma

All India Institute of Medical Sciences, New Delhi, India

Date of Web Publication29-Dec-2012

Correspondence Address:
Rajinder Kumar
All India Institute of Medical Sciences, New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.105228

Rights and Permissions

How to cite this article:
Kumar R, Sarkari A, Kakkar A. Mirror image subependymoma . Neurol India 2012;60:684-5

How to cite this URL:
Kumar R, Sarkari A, Kakkar A. Mirror image subependymoma . Neurol India [serial online] 2012 [cited 2021 Jan 20];60:684-5. Available from:

Subependymoma is a rare, benign neoplasm, accounting for less than 1% of all intracranial neoplasms. We present a case of large symptomatic bilateral subependymoma with mirror image pattern.

A 25-year-old male presented with features of raised intracranial pressure. Magnetic resonance image (MRI) showed large non-homogenous space-occupying lesions iso- to hypo-intense on T1-weighted image (T1WI) [Figure 1] and hyperintense on T2-weighted image (T2WI) [Figure 2] in bilateral occipital region in a 'mirror-image' pattern. Patient underwent staged tumor excision six weeks apart. Histopathological examination of the excised tumor on both the sides showed similar features. The tumor had clusters of monomorphic cells embedded in fibrillary matrix. There was diffuse immunopositivity for GFAP. The tumor cells were immunonegative for NeuN, synaptophysin, chromogranin, NF and EMA [Figure 3]a-d. Postoperative computed tomography (CT) scan revealed complete tumor excision [Figure 4]. Patient is well at three years of follow-up.
Figure 1: T1W1 MRI showing iso to hypointense lesion in bilateral occipital region

Click here to view
Figure 2: T2W1 MRI showing hyperintense lesion

Click here to view
Figure 3: (a-d) Histopathological features of the resected right-side tumor showing clustered nuclei in a dense fibrillary background with monomorphic round to oval nuclei in low (a) and high power (b) The left-side tumor showed similar morphological features on low and high magnification (c and d)

Click here to view
Figure 4: Postoperative CT scan at follow-up showing complete tumor excision

Click here to view

Tumors with mirror image pattern are a rare entity. This has been described with gliomas in the corpus callosum, thalamus, insular region, multicentric gliomas and rarely in metastasis. [1] It has not been described in subependymomas so far. These tumors have indolent growth so that most are still diagnosed at autopsy. [2] Such large subependymomas are very rare. Size at presentation is directly related to tumor location, with tumors that block cerebrospinal fluid (CSF) pathways presenting with smaller dimensions than tumors not impeding CSF flow. [2],[3]

On CT these lesions appear as hypodense to isodense with cystic components with poor contrast enhancement. They are hypo- to isointense on T1WI, hyperintense onT2WI and have minimal to moderate enhancement. MR-spectroscopy shows findings consistent with low-grade tumors. The differential diagnosis includes ependymoma, choroid plexus papilloma, metastasis, rarely meningioma, central neurocytoma and subependymal giant cell astrocytcoma. [4]

  References Top

1.Borkar SA, Tandon V, Kale SS, Mahapatra AK. Mirror image insular glioma. Neurol India 2010;58:978-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Nishio S, Morioka T, Mihara F, Fukui M. Subependymoma of the lateral ventricles. Neurosurg Rev 2000;23:98-103.  Back to cited text no. 2
3.Maiuri F, Gangemi M, Iaconetta G, Signorelli F, Del Basso De Caro M. Symptomatic subependymomas of the lateral ventricles. Report of eight cases. Clin Neurol Neurosurg 1997;99:17-22.  Back to cited text no. 3
4.Ragel BT, Osborn AG, Whang K, Townsend JJ, Jensen RL, Couldwell WT. Subependymomas: An analysis of clinical and imaging features. Neurosurgery 2006;58:881-90.  Back to cited text no. 4


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]

This article has been cited by
1 Bilateral lateral ventricular subependymoma with extensive multiplicity presenting with hemorrhage
FM Moinuddin,Novita Ikbar Khairunnisa,Hirofumi Hirano,Tomoko Hanada,Tsubasa Hiraki,Mari Kirishima,Kiyohisa Kamimura,Kazunori Arita
The Neuroradiology Journal. 2018; 31(1): 27
[Pubmed] | [DOI]
2 Unique Occurrence of a Subependymoma Presenting Bilaterally with Hemorrhage:A Case Report
Yasmine Miguel,Gerard Jansen,Fahad Alkherayf
Open Journal of Modern Neurosurgery. 2015; 05(02): 59
[Pubmed] | [DOI]


Print this article  Email this article
Online since 20th March '04
Published by Wolters Kluwer - Medknow