| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 61
| Issue : 1 | Page : 21--25 |
Genetic variants of phosphodiesterase 4D gene are associated with an enhanced risk for ischemic stroke in young Chinese population
Ying He1, Dong Zhi Yang2, Hui Yu3, Man Yu Li1, Qing Chuan Feng1, Hong Zheng1
1 Department of Cell Biology and Medical Genetics, Basic Medical College, Zhengzhou, China
2 Department of Bioengineering, Five Affiliated Hospital, Zhengzhou University, Zhengzhou, China
3 Department of Cardiology, Five Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Correspondence Address:
Hong Zheng
Department of Cell Biology and Medical Genetics, Basic Medical College of Zhengzhou University, Zhengzhou, Henan 450052
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.108131
Background: Previous studies have shown that the phosphodiesterase 4D (PDE4D) gene is a susceptibility gene for ischemic stroke (IS) primarily in elder populations. However, few studies have reported the role of the PDE4D gene polymorphisms in a young cohort. Aims: To investigate the association between the PDE4D gene polymorphisms and young-onset IS in Chinese population. Materials and Methods: A total of 186 young patients (18-45 years) with IS and 232 matched control subjects were recruited. Two SNPs (rs918592 and rs2910829) in PDE4D gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Odds ratio and 95% confidence intervals (95% CI) were calculated to test the association between the genetic factors and IS. Results: The rs918592A/A genotype frequency and A allele frequency, rs2910829 CT/TT genotype frequency and T allele frequency of young IS group were significantly higher than those of the control group ( P < 0.05). Besides, the frequency of Hap (A-T) was remarkably higher in the young patients than that in the controls (OR =4.047, 95% CI: 3.521-4.652). Hap (A-C) and Hap (G-C) were associated with decreased risk of IS (OR =0.640, 95% CI: 0.452-0.906; OR =0.675, 95% CI: 0.466-0.978, respectively). Conclusions: Our findings suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with IS in Chinese young population.
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