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| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 61
| Issue : 4 | Page : 360--364 |
Association of polymorphism in rs2736990 of the α-synuclein gene with Parkinson's disease in a Chinese population
Fenghua Pan1, Haixia Ding2, Hairong Dong3, Min Ye4, Weiguo Liu5, Guiyun Cui6, Jiechun Chen7, Yanfeng Wu8, Hui Wang8, Xingzhen Dai8, Haicun Shi9, Xinsheng Ding3
1 Department of Neurology, The Second Affiliated Hospital of Nanjing Medical University, Jiangjiayuan, Nanjing, Jiangsu Province 210011, People's Republic of China
2 Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, People's Republic of China
3 Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, People's Republic of China
4 The BenQ Neurological Institute, Nanjing Medical University, Nanjing, Jiangsu Province 210029, People's Republic of China
5 Department of Neurology, The Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, People's Republic of China
6 The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province 221002, People's Republic of China
7 The Second People's Hospital of Lianyungang, Haizhou, Jiangsu Province 222023, People's Republic of China
8 The Second Affiliated Hospital of Nanjing Medical University, Jiangjiayuan, Nanjing, Jiangsu Province 210011, People's Republic of China
9 The Third People's Hospital of Yancheng, Jiangsu Province 224001, People's Republic of China
Correspondence Address:
Xinsheng Ding
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Street, Nanjing, Jiangsu Province 210029
People's Republic of China
 Source of Support: Nanjing Medical University Technology
Development Foundation (2010NJMUZ57, Fenghua Pan)., Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.117595
Background and Objective: Previous genetic studies in Parkinson's disease (PD) have provided conclusive evidence for association of genes with strong biological rationale for PD. Recently several studies in different populations have found a strong association between idiopathic PD and the single-nucleotide polymorphism (SNP) rs2736990, located within an intron of the α-synuclein (SNCA) gene. In this study, we aimed to verify these findings and to explore the characteristic of the association in a subset of Chinese Han PD patients. Materials and Methods: A total of 515 unrelated patients with sporadic PD and 450 healthy ethnically matched control subjects were recruited consecutively for the study. Patients and healthy controls were genotyped for SNCA rs2736990 variant by polymerase chain reaction - ligase detection reaction. Results: Our data showed a significant association between the rs2736990 polymorphism and PD, the frequency of the allele C in PD patients was significantly higher than that in controls (P = 0.017, OR = 1.26, 95% confident intervals (CI) =1.04-1.51). The distribution of C > T genotypes was different between patients and controls (P = 0.027). Furthermore, allele C of SNP rs2736990 in early-onset PD was significantly more frequent than that in healthy controls (P = 0.007, odds ratio = 1.60, 95% CI = 1.13-2.26). Conclusions: Our study demonstrated that SNCA rs2736990 C > T polymorphism was associated with susceptibility to PD in Chinese Han population. Further studies are needed to replicate the association we found.
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