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Year : 2013  |  Volume : 61  |  Issue : 6  |  Page : 578--580

Not so "silent":The human prefrontal cortex

All India Institute of Medical Sciences, New Delhi; National Brain Research Centre, Nainwal More, Manesar, Gurgaon, Haryana, India

Correspondence Address:
Prakash Narain Tandon
National Brain Research Centre, Nainwal More, Manesar, Gurgaon, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.125242

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Little was known about the human prefrontal cortex till recently. It was thus labeled as the "silent area," "uncommitted cortex." It not only constitutes the largest component of the human brain but is the latest evolutionary addition to the mammalian brain. It endows the human beings with qualities that differentiate humans from all other animals. During the last couple of decades the advent of modern electrophysiological and imaging (functional magnetic resonance imaging, proton emission tomography, SPECT) techniques have provided a wealth of insight into its role in memory, thought, emotions, moral judgment, social behavior, evaluating rewards, and assessing its fairness or otherwise and above all self-awareness. This brief review summarize the recent significant observations on its functions and connectivity which would interest the cognitive scientists and clinicians alike.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow