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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 62  |  Issue : 2  |  Page : 149--152

Molecular analysis of α-synuclein gene in Parkinson's disease in North Karnataka, India


1 Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, India
2 Karntaka Institute for DNA Research, Pavate Nagar, Dharwad, Karnataka, India
3 Neurospeciality Centre, Belgaum, Karnataka, India

Correspondence Address:
Pramod B. Gai
Director, Karntaka Institute for DNA Research, Pavate Nagar, Dharwad - 580 003, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.132338

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Background: Parkinson's disease (PD) is a disabling neurological disorder characterized by progressive degeneration of dopaminergic neurons. Mutations analysis within the α-synuclein gene (SNCA) on chromosome 4 has been reported in the last decade. Objective: To elucidate the possible role of SNCA gene in the pathogenesis of PD in Indian population specifically in north Karnataka. Materials and Methods: The study subjects included 100 clinically diagnosed PD patients and 100 ethnically matched healthy controls. Isolated deoxyribonucleic acid (DNA) samples from both were subjected to exon-specific polymerase chain reaction (PCR) amplification and amplicons were subjected to capillary-based direct DNA sequencing. Result: No mutations were observed in SNCA gene of PD samples in comparison with control samples. Conclusion: These findings support the hypothesis that the SNCA gene mutations might be population specific and may not be playing role in causing PD in all the populations.






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