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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 62  |  Issue : 4  |  Page : 406--409

Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas


1 Department of Surgery, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
2 School of Public Health, National Defense Medical Center, Taipei, Taiwan, China
3 Department of Surgery, Division of Neurosurgery, Changhua Christian Hospital, Changhua, Taiwan, China
4 Department of Neurological Surgery, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
5 Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, and Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, China

Correspondence Address:
Dueng-Yuan Hueng
Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, and Department of Biochemistry, National Defense Medical Center, 325, Sec. 2, Cheng-Kung Rd., Neihu 11404, Taipei, Taiwan
China
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Source of Support: This study was supported in part by grants from the a surcharge of tobacco products to Ministry of Health and Welfare (MOHW103-TD-B-111-12 to D-Y Hueng), and National Science Council (NSC 102-2628-B-016 -002 -MY2 , and NSC 103- 2911-I-016-501 to D-Y Hueng), Taipei, Taiwan, ROC, Conflict of Interest: None


DOI: 10.4103/0028-3886.141278

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Background: High-grade primary gliomas are invasive and have poor outcome. The identification of biomarkers predictive of outcome in patients with gliomas is crucial for clinical follow-up. Epithelial cell transformation sequence 2 (ECT2) modulates cancer invasion, progression, metastasis and cell cycle regulation. However, its role in determining the clinical outcome of human gliomas warrants further elucidation. Materials and Methods: This study hypothesized that ECT2 is over-expressed in human gliomas. We analysis de-linked data (GDS1815/219787_s_at/ECT2) in primary high-grade glioma, and exclude 23 sheets of data without detailed information. An additional database (GDS1962/234992_x_at/ECT2) was also included to evaluation ECT2 gene expression in each pathologic grading. Results: Analysis of the Gene Expression Omnibus (GEO) profile showed that ECT2 mRNA expression level was higher in WHO grade IV (n = 81) than in grade II (n = 7, P = 0.0126) gliomas and non-tumor controls (n = 23; P = 1.65 Χ 10 -8 ). Kaplan-Meier analysis showed unfavorable survival in patients with high ECT2 mRNA levels (n = 10) than in those with low ECT2 expression (n = 67) (median survival, 106 vs. 46 weeks, P < 0.0001, by log-rank test, Hazard ratio: 0.07850, 95% CI: 0.02402-0.2565). Conclusions: ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas.






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