Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 2042  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
  »  Article in PDF (460 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

  In this Article
 »  Abstract
 » Introduction
 »  Epidemiology of ...
 »  Neuroepidemiolog...
 »  References
 »  Article Tables

 Article Access Statistics
    PDF Downloaded2437    
    Comments [Add]    
    Cited by others 50    

Recommend this journal


Table of Contents    
Year : 2014  |  Volume : 62  |  Issue : 6  |  Page : 588-598

Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors

Department of Neurology, Institute of Human Behaviour and Allied Sciences and Senior Consultant in Neurology, Sir Ganga Ram Hospital, New Delhi, India

Date of Submission16-Oct-2014
Date of Decision29-Dec-2014
Date of Acceptance05-Dec-2014
Date of Web Publication16-Jan-2015

Correspondence Address:
M Gourie-Devi
Emeritus Professor of Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi - 110 096
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.149365

Rights and Permissions

 » Abstract 

Growth and development of neuroepidemiology in India during the last four decades has been documented highlighting the historical milestones. The prevalence rates of the spectrum of neurological disorders from different regions of the country ranged from 967-4,070 with a mean of 2394 per 100000 population, providing a rough estimate of over 30 million people with neurological disorders (excluding neuroinfections and traumatic injuries). Prevalence and incidence rates of common disorders including epilepsy, stroke, Parkinson's disease and tremors determined through population-based surveys show considerable variation across different regions of the country. The need for a standardized screening questionnaire, uniform methodology for case ascertainment and diagnosis is an essential requiste for generating robust national data on neurological disorders. Higher rates of prevalence of neurological disorders in rural areas, 6-8 million people with epilepsy and high case fatality rates of stroke (27-42%) call for urgent strategies to establish outreach neurology services to cater to remote and rural areas, develop National Epilepsy Control Program and establish stroke units at different levels of health care pyramid.

Keywords: Epilepsy, incidence, India, neuroepidemiology, Parkinson′s disease, prevalence, screening questionnaire, stroke, tremors

How to cite this article:
Gourie-Devi M. Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors. Neurol India 2014;62:588-98

How to cite this URL:
Gourie-Devi M. Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors. Neurol India [serial online] 2014 [cited 2023 Dec 3];62:588-98. Available from:

 » Introduction Top

Developing countries, including India are passing through a phase of epidemiological transition with increasing burden of non-communicable diseases (NCD) consequent to transformation of scenario with improvement of health care services in preventive and promotive domains. Among the NCDs, neurological disorders form a significant proportion of global burden of disease. [1],[2] Two important documents published by World Health Organization (WHO) and World Federation of Neurology bring to forefront the public health challenges posed in dealing with neurological disorders particularly in the developing countries with limited resources. [3],[4] In this scenario, it is crucial to determine through neuroepidemiological approach the magnitude and pattern of neurological disorders in India to facilitate planning and prioritising health needs at the local, regional and national levels of health care delivery system with necessary human resources, development of infrastructure, to provide accessible and affordable medical care with allocation of requisite funds to fulfill these objectives. The data from epidemiological surveys in developed countries cannot be extrapolated to India in view of social, cultural and ethnic variations. Hospital-based data although critical for management, does not adequately reflect the burden of the disease in the community or the complex issues influencing the natural history. In India, as in other developing countries, there is a paucity of trained neurologists necessitating ground plans and policies appropriate to the socioeconomic and cultural background for conducting neuroepidemiological studies.

This review focuses on the growth and development of the discipline of neuroepidemiology in India, methodological issues encountered and the strategies developed to address them, analysis of data on prevalence and pattern of neurological disorders and epidemiology of selected disorders including epilepsy, stroke, Parkinson's disease and tremors. Only the publications on population based studies have been included in this review. Earlier reviews by the author had addressed some of the issues. [5],[6],[7]

 » Neuroepidemiology in India Top

Background and methodological issues

In 1960s neuroepidemiological studies in India were restricted to single disorders such as epilepsy [8] and stroke [9] and it was only two decades later that community-based studies for a spectrum of neurological disorders were initiated in Bangalore, Bombay, Delhi and Kashmir which provided the foundation and frame work for the emergence of the discipline of neuroepidemiology in India. [10],[11],[12],[13],[14] To overcome the major constraint of few neurologists in developing countries and also to optimize the time spent by the neurologist, Schoenberg recommended strategy of two-stage methodology; the first stage comprised of administration of questionnaire of symptoms and simple clinical examination by health care personnel and second stage examination by neurologist of individuals identified as having neurological disorder. [15] The Neuroscience program of World Health Organization (WHO) developed the screening questionnaire "WHO protocol" to detect individuals with epilepsy, cerebrovascular disorders, peripheral neuropathy, extrapyramidal disorders (including Parkinson's disease) migraine and intracranial neoplasms and was pilot tested in Nigeria. [16],[17] Gourie-Devi et al., observed that in the Indian context clinical examination by non-medical professionals was not acceptable to the people, hence only the questionnaire was administered by trained field workers and neurological examination of 'screened positive' subjects was done by neurologist. [11] They further modified and expanded the WHO screening questionnaire to include a wider spectrum of neurological disorders and using this instrument NEPSIG (Neuro Epidemiological Study In Gowribidanur) through a two-stage method of survey, the feasibility and logistics in identifying neurological disorders in a population of 57660 comprising of urban and rural population of Gowribidanur town and the surrounding villages, was demonstrated. [10],[11] Arguably all these pioneering efforts galvanized and sensitized the neurologists in the country to the discipline of neuroepidemiology and Indian Council of Medical Research (ICMR) identified neuroepidemiology as a thrust area of research and has been providing grants in a task force mode of support. Certain important concerns were the problems in comparing the data emanating from different regions of the country and the pitfalls identified were small sample size not representative of the population, lack of uniformity in case finding, case ascertainment, training of field workers, standardized screening questionnaires and definitions of diseases. These methodological issues have been dealt with at length through a format of questions and answers for conducting neuroepidemiological surveys in a developing country. [18] To overcome these lacunae a comprehensive Manual was developed at the National Institute of Mental Health and Neurosciences (NIMHANS) with support from ICMR, with focus on logistics and operational aspects of conducting neuroepidemiological survey in a developing country including selection of study population, structured training program of field workers, screening questionnaires for adults and children and definition of diseases. [19],[20] These questionnaires were validated in a pilot study by Gourie-Devi et al., and later used in the major Bangalore Urban-Rural Neuroepidemiological (BURN) survey. [21],[22] These standardized questionnaires developed by NIMHANS, with minor modifications, based on requirements of the survey and local situation, have been used in neuroepidemiological studies in different regions of the country. [23],[24],[25] It is heartening that the concerns articulated by the author in late 1980s "Can India afford neuroepidemiology" have been firmly dispelled. [26]

Prevalence and pattern of neurological disorders

Prevalence of neurological disorders was determined through house to house surveys in six studies from different regions of the country comprising of rural population in all studies and urban population in two of them. The crude prevalence rate varied from 967-4,070 per 100000 population with an average of 2394 per 100000 population [Table 1]. [10],[13],[14],[22],[27],[28] Based on this data it is estimated that for the current population of 1.27 billion, approximately 30 million people suffer from neurological disorders in India. This is an underestimate of the burden since neuroinfections, traumatic injuries and neoplasms and metabolic disorders have not been included in the surveys. The low prevalence rate reported in Kashmir study may be due to non inclusion of headache which is the most common disorder in the community. The variation in prevalence rates across regions can be attributed to differences in case identification, definition of the diseases, non inclusion of some neurological disorders and also due to certain locally prevalent disorders. Neurological disorders affect all age-groups, and age-specific prevalence rates show increasing prevalence till fourth decade followed by decline to seventh decade. In Bangalore, however, increasing rates to seventh decade were observed indicating that the geriatric population suffers from considerable burden of neurological disorders (age specific prevalence rates per 100000; for age < 15 years: 2653; for 31-40 years: 3932; >60 years: 5012). [22] The neurological disorders were more common in rural compared to the urban population with a ratio of 1.9:1 and the prevalence rate was higher in females than males in Bangalore and Malda. [22],[27] The prevalence rates in India are comparable to those in Nigeria, [29] and Ethopia, [30] but lower than in Sicily [31] and Tunisia. [32]
Table 1: Prevalence of neurological disorders (per 100,000 population)

Click here to view

A wide spectrum of neurological disorders were detected in these surveys including common disorders such as epilepsy, febrile convulsions, headache, cerebrovascular disorders, tremors and mental retardation and others with lower prevalence comprising of Parkinson's disease and peripheral neuropathy [Table 2]. [10],[13],[14],[22],[27],[28] Most of the disorders had higher prevalence in rural population compared to urban population. Since there were only two studies of urban population in South India, more surveys of urban population from other regions of the country are necessary to confirm the observation. Poliomyelitis with residual deficit were detected in all the surveys reflecting that there is a considerable pool of survivors with poliomyelitis with public health concerns and need for physiotherapy and rehabilitation services. Major outbreaks of Japanese encephalitis in state of Karnataka accounted for the prevalence of postencephalitic sequelae in Gowribidanur and Bangalore, demonstrating the regional health problems. [10],[22] It is noteworthy that epilepsy, headache, febrile convulsions and cerebrovascular disorder together constituted 80% of all neurological disorders in the community. This data obviously has implication in developing strategy for health services with focus on neurology services for these disorders at the primary and secondary level of health care.
Table 2: Prevalence rates and pattern of major neurological disorders (per 100000 population)*

Click here to view

 » Epidemiology of Individual Neurologic Disorders Top

Epidemiology of epilepsy

Prevalence of epilepsy

The global burden of disease study of 2000 provides an estimate of 50 million people with epilepsy and more than 80% of them in developing countries. [33] In India Epilepsy was included in mental morbidity surveys during 1960s and 1970s which were conducted by psychiatrists in different regions of the country with research grant from ICMR [Table 3]. [34],[35],[36],[37] The crude prevalence rate varied from 2.2-10.4 per 1000 population. The concerns were the small sample size in all, except one, of these studies and the definition of epilepsy was not included. It is also not clear if only 'active epilepsy' was included and whether the questionnaire was formulated to detect generalized, focal and complex partial seizures. In this context it is pertinent to acknowledge the commendable contribution of psychiatrists for including epilepsy to provide primary care under the National Mental Health Program (NMHP) initiated in 1982 and now further expanded to include more than 200 districts by Government of India. [38],[39] A significant mile stone was the multicentre "Collaborative epidemiological study of epilepsy in India", PL 480 funded project of ICMR, which was initiated in 1969 and included, Bangalore, Bombay, Calcutta, New Delhi and Madras. Although this was hospital based, the study provides valuable data on clinical parameters, electroencephalographic, and psychosocial aspects and follows up over 4 years. [40] From 1968-2008, fourteen surveys have been done in different regions of the country to determine the prevalence of epilepsy [Table 4]; four of them comprising both urban and rural population, [8],[10],[22],[46] seven only rural population [13],[25],[27],[28],[42],[43],[44] and three only urban population [23],[41],[45] were included. Most of the studies are from North, South and East India, one report from West India but none from vast regions of Central and North-East regions. In the earlier studies the WHO questionnaire and in the last decade NIMHANS questionnaire has been used for survey. The mean crude prevalence rate was 5.7 per 1000 population (range 2.5-11.9) for the entire surveyed population; 5.3 (2.5-7.5) in urban population and slightly higher rate of 5.8 (2.5-11.9) in rural population. There was no significant difference in rates between men and women. The peak prevalence rates were in the second and third decades and a second peak in the elderly due to occurrence of seizures due to stroke. In a meta-analysis published 15 years ago, Sridharan and Murthy reported similar overall prevalence of 5.3/1000; in urban areas it was 5.1 and in rural area was 5.5/1000. [47] The slightly higher rates currently observed may be due to the recent surveys reporting higher prevalence in rural area attributed to neurocysticercosis (NCC) contributing to a significant proportion of seizures in the community. [25],[46] In population based surveys only two studies focused on NCC contributing to prevalence of epilepsy. In the study from Vellore, South India [46] 34% of patients with active epilepsy were confirmed to have NCC by CT scan and enzyme-linked immunotransfer blot (EITB) and from Dehradun, North India, 35% had NCC based only on CT scan. [25] It is interesting to note that the overall prevalence rate of epilepsy has almost remained constant over the last two decades. Based on the prevalence data it is estimated that there are 6 to 8 million people with epilepsy in India.
Table 3: Prevalence rates of epilepsy based on mental morbidity surveys from 1962 to 1976 (per 1000 population)

Click here to view
Table 4: Prevalence rates of epilepsy based on Neuroepidemiological surveys conducted from 1968 to 2008 (per 1000 population)

Click here to view

The crude prevalence rate of epilepsy in other developing countries has also a wide variation: 4.4 and 4.6 in China, [48],[49] 7.0 in Turkey, [50] 9.0 in Srilanka [51] and 9.9 in Pakistan [52] per 1000 population. In both Pakistan and Turkey the prevalence was much higher in rural compared to urban population (Pakistan-14.8 in rural and 7.4 in urban; Turkey-8.8 in rural and 4.5 in urban). [50] Similarly in Tanzania the rate was 10.2/1000 in the rural population and an interesting observation was that the rates varied widely over a range of 5.7-37.1 among different villages in the sampled area. [53]

Incidence of epilepsy

The crude annual incidence rates per 100000, in three studies which determined the incidence of epilepsy through community-based studies were 49.3 for rural population of South India, [43] 42.1 for rural population of West Bengal [54] and 25.2 for urban population of Kolkata. [55] The rates in India are comparable to developed countries with the reported rates varying from 28.9-53.1 [56] and lower than in other developing countries at 69.4 in Benin, [57] 73.0 in Tanzania, [53] 77.0 in Kenya, [58] and 92.0 in Honduras, [59] per 100000 population. These variations across countries and regions may be due to locally prevalent risk factors such as infections (NCC) and the level of primary health care for head injuries, obstetric, perinatal and pediatric services, in preventing birth trauma and prompt management of infections in neonates and infancy.

Treatment gap in epilepsy

Proportion of patients with active epilepsy not receiving treatment in the developing countries is very high varying from 80-94%. [60] In India treatment gap (TG) was determined through prevalence studies and the TG was lowest at 29% among Parsis in Bombay, [41] 38% in Kerala, [45] 50% in Bangalore, Karnataka, [61] 65% in West Bengal, [28] 75% in Kashmir, [42] and 78% in Yelandur, Karnataka. [43] The TG was lower in urban population compared to rural areas perhaps due to better awareness about the disorder and availability of health services in closer proximity. In the systematic review of 74 population based studies of prevalence of epilepsy from 38 countries, the treatment gap varied widely among countries; in low-income countries it was 75-95%, over 50% in lower middle and upper middle-income countries and less than 10% in high-income countries. [62] The TG also varied considerably within countries and was higher in rural areas.

Epidemiology of cerebrovascular disorders

Cerebrovascular disorders (CVD) are increasing in prevalence and incidence in India due to rapid escalation of risk factors including hypertension diabetes mellitus, smoking and obesity affecting considerable proportion of adult population. Global Burden of Disease study shows that of the 9.4 million deaths in India, 619,000 were due to stroke and Disability Adjusted Life Years (DALYs) lost were 28.5 million highlighting the fact that CVD leads to considerable mortality and morbidity. [63] Therefore there is likely to be a major crisis in India unless national measures to prevent/control risk factors of CVD are instituted and adequate services are put in place for the management and rehabilitation of stroke. [64] Another issue of concern is that 20-30% of strokes occur in people younger than 45 years and is more frequently seen in India compared to the west. [64]

Prevalence of stroke

Although there are numerous hospital based studies of stroke in India only a few population-based surveys have been done to determine the prevalence of stroke and the very first survey on a large urban and rural population was conducted by Abraham et al., in late 1960's in Vellore. [9] Since most studies used WHO definition of stroke, only completed stroke were included in the surveys and transient ischemic attacks were excluded underestimating the actual burden of cerebrovascular disorders. During the last four decades community-based studies in different regions of the country showed crude prevalence rates of completed strokes varying from 52-472 per 100000 persons, with the exception of a very high rate of 842 among Parsis, a distinct ethnic community [Table 5] .[9],[10],[13],[14],[22],[27],[65],[67],[69],[70] (The study from Rhotak was a part of WHO Collaborative study of 17 centers in developing and developed countries which was latter extended to include a larger sample). [65],[66] The mean CPR in urban population (excluding the prevalence rate in Parsis) was 153/100000 (range 44-472) and in rural region was 93/100000 (range 31-165). Higher prevalence in urban compared to rural regions has been reported in South Asia. [71] To a certain extent this wide variation can be explained by differences in methodology, age structure of population, however there could be genuine regional differences due to the degree and nature of risk factors. It is noteworthy that surveys conducted in two different areas in Kolkata showed a remarkable difference in crude prevalence rate; 147 in Southern part [69] and 487 (per 100000 from Central part [23] re-emphasizing the need to explore further to identify the risk factors by case control studies. Even allowing for these variations, a matter of concern is that in the last two decades there is a significant increase in prevalence rate of stroke. Meta-analysis of studies conducted from 1980-2001 gave a weighted average of prevalence rates of 154 per 100000 population. [72] Pooled analysis through forecasting method has shown that the estimated prevalence rates of stroke for the years 2000 and 2015 are 108 and 133 per 100,00 population, respectively, indicating a dramatic rise in prevalence of stroke over a period of 15 years, and by 2015 it is estimated that there will be 1,667,372 cases of stroke in India. [73] The prevalence rates are similar to other developing countries. [74]
Table 5: Prevalence of stroke in india: Rate per 100000 population

Click here to view

Age-specific prevalence rates increased with the maximum prevalence rates in the 6 th and 7 th decades in most of the surveys. [68] The crude prevalence and age adjusted rates of stroke in rural Kashmir were high, almost double, in males (187 and 334/100000) compared to women (94 and 175/100000); [68] higher rate in men was also reported in Parsis. [67] In rural population of Eastern India the prevalence rate was equal among men and women. [28] In contrast, in Kolkota age-adjusted prevalence rate was three times higher in women compared to men (men-196 and women 564 per 100000 population which was attributed it to poor control of hypertension in women. [69]

Incidence of stroke

The overall annual incidence rates are available only from few regions in the country; the rates per 100000 population varied from 13 in Vellore [9] 33 in Rohtak [65] to 36/100000 in Kolkata. [69] The age adjusted rate per 100000 persons was 105 in Kolkata, [69] 135 in Trivandrum (based on Trivandrum stroke registry), [75] and 152 for Mumbai (based on "Mumbai Stroke Registry) [76] which are similar to incidence rates/100000 of China (in three cities 76 to 150/100000), [77] and also as in developed countries including Perth (160), South London (130/100000). [78] In view of the problems of determining the actual burden of strokes in developing countries, particularly in view of rising trend in low-income and middle-income countries, [79] stepwise approach has been proposed by WHO to facilitate standardized approach to data collection and surveillance. [80],[81] The strategy essentially consists of three steps: Outcome of stroke patients in hospital, fatal events in the community and non-fatal events in the community and it is envisaged that this approach will provide the framework for creation of registries. [80],[81],[82] A multicentre study "Indian Collaborative Acute Stroke Study (ICASS)" based on step approach was initiated in seven cities and this experience has led to concept of establishing registries. [64],[75],[83],[84] Currently feasibility studies are underway for urban and rural registries under the aegis of ICMR with the goal to develop National stroke registry.

Risk factors for stroke

In population based case control studies hypertension was observed to be the most important risk factor in urban population in Kolkata and among Parsis in Mumbai, however diabetes mellitus was also a significant risk factor among Parsis although not significant in Kolkata. [69],[85] In another community based survey in rural Kashmir, 58% were detected to have hypertension. [68] Surveys in different regions of India have shown that hypertension is widely prevalent in India affecting 25-40% of adults in urban and 12-17% in rural areas. [86]

Mortality in stroke

Deaths due to stroke account for a significant proportion of all deaths in the community in India is evident from the elegant study by Joshi et al., who determined mortality due to chronic diseases through verbal autopsy covering a population of 180162 in 45 villages in East and West Godavari in Andhra Pradesh during the period from 2003-2004. [87] Stroke was the cause of death in 13% of the total 1354 deaths and was comparable to ischemic heart disease (14%). The case fatality was 27% in Trivandrum, Kerala, [75] 30%in Mumbai, [76] and 42% in Kolkata [70],[88] by 28-30 days, following stroke and a matter of serious concern is early deaths of 20% in Kerala [75] and 33% in Kolkata [88] in the first 7-10 days. The lower case fatality rate in Kerala reflects better health care than in Kolkata. In the recent long term study in Kolkata over 7 years, the case fatality was 59% at 5 years and 61% at 7 years. [88]

In view of the increasing burden of cardiovascular diseases and stroke and high prevalence of risk factors of hypertension and diabetes, [89] there is an urgent need to initiate preventive programs. [76],[90] It is a good augury that Government of India had launched the pilot phase of "National program for prevention and control of diabetes, cardiovascular diseases and stroke" in 2008 [91] in 100 districts and it is planned to expand the program to all districts. With effective implementation of the program it is expected that there would be a tangible reduction in stroke incidence and prevalence.

Movement disorders

Parkinson's disease

Among the movement disorders, epidemiology of Parkinson's disease has been better studied than other disorders in India. Population based surveys (excluding Parsis) have shown a crude prevalence rate (CPR) of Parkinson's disease varying from 6-53/100000 [Table 6]. [14],[19],[22],[26],[27],[28],[93] In the survey in Bangalore the rate was three times higher in rural compared to urban region (Rural 41 and urban 14/100000. [22] The CPR of 328 and age-adjusted rate of 192/100000 population in the Parsis is considerably higher than in the developing countries including China, Nigeria and non-Parsi community of India and is even more than developed countries. [92] Parsis form an ethnic community, distinct from the rest of population in India, therefore this data cannot be extrapolated to determine the estimates in the general population. Age-specific prevalence rates for PD increase with advancing age [14],[26],[28],[92] and are as high as 247/100000 above age of 60. [14] In most studies sex-specific prevalence rates were higher in men than in women with the exception of studies from Eastern India which reported that women were more commonly affected than men and this was attributed to longer life expectancy in women. [23],[28] Incidence and mortality rates of PD are available only from one recent community based study; average age-adjusted incidence rate for the period 2003-2007 was 5.7/100000 per year and the average annual mortality rate during the same period was 2.9/100000 per year. [93] The incidence rates were much higher in developed countries including United Kingdom [94] (MacDonald-2000) Japan [95] (Harada 1983) and Rochester [96] (Rajput 1984) and lower in China [97],[98] (Li 1985B, Wang 1996) compared to India.
Table 6: Prevalence of Parkinson's disease in India: Rate per 100000 population

Click here to view

The overall prevalence and incidence of Parkinson's disease in India is low. The prevalence studies had used WHO questionnaire with modifications or NIMHANS questionnaire, which were designed to detect a spectrum of neurological disorders. It is possible that screening questionnaire specifically focused to elicit more detailed information of the symptoms of PD would provide more reliable data. Anderson et al., [99] elaborated on the issues related to case ascertainment in prevalence surveys of Parkinson's disease in different countries and emphasized the importance of validation and Muthane et al., [100] reiterating these problems focused on specific concerns in conducting prevalence studies in India. Sarangmath et al., [101] validated Parkinson's disease screening questionnaire suited to Indian conditions which could be administered by nonmedical persons and since the sensitivity and specificity were high the authors suggested that it can be effectively used in developing countries for population based surveys. In future using this questionnaire and with uniform methodology if community surveys are conducted in the country, it will be possible to generate comparable data across different regions.

In the elderly homes in Bangalore prevalence of PD was three times higher in Indians compared to Anglo-Indians (mixed Indian and British ancestry) suggesting genetic background to the disorder since both the groups were from shared environment. [102] In contrast although the prevalence of PD in Indians living in India is low, community based survey in Singapore showed interesting observation of age-adjusted prevalence rates in Indians (0.28%), Malay (0.29%) and Chinese (0.33%), which were comparable to that of Western countries. [103] Similarly Chinese in Taiwan had a higher incidence rate than those in mainland China. [97],[98],[104] These data suggest that environmental factors may be of greater relevance than genetic factors in the pathogenesis of Parkinson's disease. With this conflicting evidences it becomes clear that there is a need to carry out in-depth studies to analyze the relative contribution of environmental and genetic factors to the development of the disorder. Temporal trends in prevalence of PD is best illustrated by low prevalence rate of 57/100000 in China reported in early 1990s [105] and recently with improved methodology and survey of large population showed a prevalence rate of 1.7% in the age‐group of 65 years and above [106] comparable to Rotterdam and seven European studies. [107] Cognizance of temporal trends in China has to be taken since a similar situation may arise in India which would demand detailed assessment of factors such as life expectancy, survival, treatment options and changing environmental factors.

The low prevalence of PD in India (with the exception of Parsi population) compared to the Western countries is at variance with the interesting observations made through a meticulous study by Muthane et al., [108] that normal human brains in India have 40% lower number of melonized neurons in substantia nigra compared to brains in United Kingdom. However there was no age-related progressive loss of dopaminergic neurons as is expected. [109] Although there are fewer number of pigmented neurons the dopamine produced was comparable to the levels observed in the West. [108] These observations and possibly some protective factors, account for the low prevalence of PD in India. [108]

Undiagnosed PD in the elderly is a problematic issue in many countries and the patients therefore do not have the benefit of treatment and necessary health care services. In old age homes in Bangalore, PD was diagnosed for the first time in17.8% of 612 residents highlighting the fact of poor awareness about the disorder. [110] A population based survey in China showed that 48% of PD cases were undiagnosed and were detected only during the survey. [106]

Determination of risk factors in Parkinson's disease is difficult in the absence of a biological marker, its occurrence in the elderly and relative infrequency. Therefore it is not surprising that there are only three studies from India, two were hospital based in Delhi [111] and Eastern India, [112] and one population-based study in Kolkata. [93] Family history of PD and past history of depression were associated with increased risk in studies at Delhi and Eastern India. The additional risk factors in the Delhi study were male gender and well water drinking while in Eastern India exposure to pesticides, other toxins and rural living. In Kolkata hypertension was a risk factor and interestingly in all the three studies tobacco smoking or chewing had protective effect. Almost similar observations were made in a case-control study in China with positive family history, living near rubber plants, drinking river-water being associated with an increased risk and drinking well water, living in small cities and drinking liquor with decreased risk of developing PD. [113]


Essential tremors (ET) were the commonest among all movement disorders with overall prevalence rates varying over a wide range of 8-395/100000 [[Table 2], Das et al] [10],[13],[14],[24],[27],[28],[114] The rural population of Malda, West Bengal [27] had the lowest prevalence rate while the highest was in urban population of Kolkata and above 40 years it was 910/100000. [114] The crude prevalence rate for the Parsis was exceptionally high at 1663/100000 and age-specific prevalence rates showed increase with age beyond 40 years at 2763/100000. [115] Methodological issues particularly the questionnaire and definition might have contributed to some extent to the variation, but it would be worth-while to conduct well planned studies to identify environmental factors and neurobiological and genetic basis of tremors in the context of the local population. In other developing countries the population based prevalence rates are similar to the rates in India: for China-11, [97] Tanzania-41, [116] and 237/100000 for Singapore. [117]

Future Prospects

This review makes it abundantly clear that there are lacunae in conducting population based surveys in India. Standardized questionnaires, uniform methods of case ascertainment, and diagnostic criteria will facilitate collection of robust national data of prevalence and incidence of neurological disorders. If regional differences were to be observed then search for etiological basis will move forwards the understanding of the disorder. Neuroepidemiological studies have been conducted from Northern, Southern, Eastern and Western regions of the country but there are no reports from Central India and North Eastern regions. Attempts have to be made to generate data in these regions. Focus should be on development of cohorts in the community which will help in planning interventional studies and also facilitate studies on natural history of neurological disorders.

The estimated burden of neurological disorders (excluding infections, traumatic injuries) of 30 million demands a public health approach, availability and accessibility of health care services. Paucity of trained neurologists necessitates redefining health services with integration of neurology care in the general health care and optimal utilization of the existing three tier-system of health services and implement the tested models for delivery of neurology care at primary levels. [118],[119] District model for providing services to people with epilepsy has been expanded to the concept of "National epilepsy control program". [61],[120],[121] Analysis of temporal trends in Asia including India clearly indicates increase in incidence of stroke with a significant proportion of strokes occurring in the young. [122] To reduce the stroke fatality and disability it has been suggested that stroke units can be established in low and middle income countries in cost effective manner. [123] Through a well planned multipronged targeted approach it is practical and feasible to provide neurology care, even to the remote and rural areas, leading to decrease in mortality, disability and improved quality of life.

 » References Top

Murray CJ, Lopez AD. The global burden of disease. Boston: Harvard School of Public Health; 1996.  Back to cited text no. 1
National commission on macroeconomics and health. Burden of disease in India. Ministry of Health and Family Welfare, Government of India, New Delhi; 2005. p. 367.  Back to cited text no. 2
World Health Organisation. Neurological disorders, Public health challenges. Geneva: World Health Organisation; 2006. p. 218.  Back to cited text no. 3
World Health Organisation, World Federation of Neurology. Atlas. Country resources for neurological disorders. Geneva: World Health Organisation; 2004. p. 59.  Back to cited text no. 4
Gourie-Devi M, Gururaj G, Satishchandra P. Neuroepidemiology in India. A perspective. In: Clifford RF, editor. Recent Advances in Tropical Neurology. Amsterdam: Elsevier Science Publishers BV; 1995. p. 17-30.  Back to cited text no. 5
Gourie-Devi M, Gururaj G, Satishchandra P. Neuroepidemiology in India: Development during three decades. NIMHANS J 1999;17:379-87.  Back to cited text no. 6
Gourie-Devi M, Gururaj G, Satishchandra P. Neuroepidemiology: Present insights and future prospects. NIMHANS J 1999;17:423-37.  Back to cited text no. 7
Mathai KV. Final report. Investigations into methods for rehabilitation of persons disabled by convulsive disorders. SRS Project No. 19-P-58113- F-0l. Vellore, Dept of Neurol Sci., CMC; 1971.  Back to cited text no. 8
Abraham J, Rao PS, Inbaraj SG, Shetty G, Jose CJ. An epidemiological study of hemiplegia due to stroke in South India. Stroke 1970;1:477-81.  Back to cited text no. 9
GourieDevi M, Rao VN, Prakashi R. Neuroepidemiological study in semiurban and rural areas in South India: Pattern of Neurological Disorders including Motor Neurone Disease In: GourieDevi M, editor. Motor Neurone Disease: Global Clinical Patterns and International Research. New Delhi: Oxford and IBH; 1987. p. 11-21.  Back to cited text no. 10
Gourie-Devi M, Rao VN, Prakashi R. A protocol to detect neurological disorders in the community. Indian J Med Res 1988;88:443-9.  Back to cited text no. 11
Bharucha NE, Bharucha EP, Dastur HD, Schoenberg BS. Pilot survey of the prevalence of neurologic disorders in the Parsi community of Bombay. Am J Prev Med 1987;3:293-9.  Back to cited text no. 12
Kapoor SK, Banerjee AK. Prevalence of common neurological diseases in a rural community of India. Indian J Community Med 1989;14:171-6.  Back to cited text no. 13
  Medknow Journal  
Razdan S, Kaul RL, Motta A, Kaul S, Bhatt RK. Prevalence and pattern of major neurological disorders in rural Kashmir (India) in 1986. Neuroepidemiology 1994;13:113-9.  Back to cited text no. 14
Schoenberg BS. Clinical neuroepidemiology in developing countries. Neurology with few neurologists. Neuroepidemiology 1982;1:137-42.  Back to cited text no. 15
World Health Organisation. Research protocol for measuring the prevalence of neurological disorders in developing countries. Neurosciences programme, Geneva: World Health Organisation; 1981. p. 15.  Back to cited text no. 16
Osuntokun BO, Schoenberg BS, Nottidge VA, Adeuja A, Kale O, Adeyefa A, et al. Research protocol for measuring the prevalence of neurological disorders in developing countries. Results of a pilot study in Nigeria. Neuroepidemiology 1982;1:143-53.  Back to cited text no. 17
GourieDevi M, Anderson DW, Rao VN. Neuroepidemiologic survey in a developing country: Some questions and answers. In: Anderson DW, editor. Neuroepidemiology: A tribute to Bruce Schoenberg. Boca Raton: CRC Press; 1991. p. 13-23.  Back to cited text no. 18
GourieDevi M, Gururaj G, Satishchandra P. Neuroepidemiology in developing countries Manual for Descriptive Studies. National Institute of Mental Health and Neuro Sciences, Bangalore. (NIMHANS Publication No. 33); 1994. p. 74.  Back to cited text no. 19
Gourie-Devi M, Gururaj G, Satishchandra P. Neuroepidemiology in developing countries. A manual for descriptive studies. 2 nd ed. Bangalore. Prism Books Pvt Ltd; 1997. p. 98.  Back to cited text no. 20
Gourie-Devi M, Gururaj G, Satishchandra P, Subbakrishna DK. Neuro-epidemiological pilot survey of an urban population in a developing country. A study in Bangalore, South India. Neuroepidemiology 1996;15:313-20.  Back to cited text no. 21
Gourie-Devi M, Gururaj G, Satishchandra P, Subbakrishna DK. Prevalence of neurological disorders in Bangalore, India: A community-based study with a comparison between urban and rural areas. Neuroepidemiology 2004;23:261-8.  Back to cited text no. 22
Das SK, Biswas A, Roy T, Banerjee TK, Mukherjee CS, Raut DK, et al. A random sample survey for prevalence of major neurological disorders in Kolkata. Indian J Med Res 2006;124:163-72.  Back to cited text no. 23
[PUBMED]  Medknow Journal  
Das SK, Biswas A, Roy J, Bose P, Roy T, Banerjee TK, et al. Prevalence of major neurological disorders among geriatric population in the metropolitan city of Kolkata. J Assoc Physicians India 2008;56:175-81.  Back to cited text no. 24
Goel D, Dhanai JS, Agarwal A, Mehlotra V, Saxena V. Neurocysticercosis and its impact on crude prevalence rate of epilepsy in an Indian community. Neurol India 2011;59:37-40.  Back to cited text no. 25
[PUBMED]  Medknow Journal  
GourieDevi M. Can India afford Neuroepidemiology? Neurol India 1987;35:125-7.  Back to cited text no. 26
Das SK, Sanyal K. Neuroepidemiology of major neurological disorders in rural Bengal. Neurol India 1996;44:47-58.  Back to cited text no. 27
Saha SP, Bhattacharya S, Das SK, Maity B, Roy T, Raut DK. Epidemiological study of neurological disorders in a rural population of Eastern India. J Indian Med Assoc 2003;101:299-300, 302-4.  Back to cited text no. 28
Osuntokun BO, Adeuja AO, Schoenberg BS, Bademosi O, Nottidge VA, Olumide AO, et al. Neurological disorders in Nigerian Africans: A community based study. Acta Neurol Scand 1987;75:13-21.  Back to cited text no. 29
Tekle-Haimanot R, Abebe M, Gebre-Mariam A, Forsgren L, Heijbel J, Holmgren G, et al. Community-based study of neurological disorders in rural central Ethopia. Neuroepidemiology 1990;9:263-77.  Back to cited text no. 30
Meneghini F, Rocca WA, Grigoletto F, Morgante L, Reggio A, Savettieri G, et al. Door-to-door prevalence survey of neurological diseases in a Sicilian population. Background and methods. The Sicilian Neuro-Epidemiologic study (SNES) group. Neuroepidemiology 1991;10:70-85.  Back to cited text no. 31
Attia Romdhane N, Ben Hamida M, Mirabet A, Larnaout A, Samoud S, Ben Hamda A, et al. Prevalence study of neurologic disorders in Kelibia (Tunisia). Neuroepidemiology 1993;12:285-99.  Back to cited text no. 32
Leonardi MT, Ustun TB. The global burden of epilepsy. Epilepsia 2002;43:21-5.  Back to cited text no. 33
Surya NC, Datta SP, Krishna RG, Sundaram D, Kutty J. Mental morbidity in Pondicherry (1962-1963). Trans AIIMH 1964;4:50-61.  Back to cited text no. 34
Dube KC. A study of prevalence and biosocial variables in mental illness in a rural and an urban community in Uttar Pradesh--India. Acta Psychiatr Scand 1970;46:327-59.  Back to cited text no. 35
Sethi BB, Gupta SC, Kumar R, Kumari P. A psychiatric survey of 500 rural families. Indian J Psychiatry 1972;14:183-96.  Back to cited text no. 36
  Medknow Journal  
Nandi DN, Banerjee G, Boral GC, Ganguli H, Ajmany (Sachdev) S, Ghosh A, et al. Socio-economic status and prevalence of mental disorders in certain rural communities in India. Acta Psychiatr Scand 1979;59:276-93.  Back to cited text no. 37
National mental health program for India. New Delhi. Government of India, Nirman Bhawan; 1982.  Back to cited text no. 38
Murthy RS. Mental health programme in the 11 th Five Year Plan. Indian J Med Res 2007;125:707-11.  Back to cited text no. 39
[PUBMED]  Medknow Journal  
Tandon PN. Epilepsy in India. (Report based on a multicentric study on epidemiology of epilepsy carried out as a PL 480 funded project of the Indian Council of Medical Research). New Delhi: Indian Council of Medical Research; 1989. p. 183.  Back to cited text no. 40
Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Prevalence of epilepsy in the Parsi community of Bombay. Epilepsia 1988;29:111-5.  Back to cited text no. 41
Koul R, Razdan S, Motta A. Prevalence and pattern of epilepsy (Lath/Mirgi/Laran) in rural Kashmir, India. Epilepsia 1988;29:116-22.  Back to cited text no. 42
Mani KS, Rangan G, Srinivas HV, Kalyanasundaram S, Narendran S, Reddy AK. The Yelandur study: A community-based approach to epilepsy in rural South India -- epidemiological aspects. Seizure 1998;7:281-8.  Back to cited text no. 43
Kokkat AJ, Verma AK. Prevalence of seizures and paralysis in a rural community. J Indian Med Assoc 1996;96:43-5.  Back to cited text no. 44
Radhakrishnan K, Pandian JD, Santoshkumar T, Thomas SV, Deetha TD, Sarma PS, et al. Prevalence, knowledge, attitude and practice of epilepsy in Kerala, South India. Epilepsia 2000;41:1027-35.  Back to cited text no. 45
Rajshekhar V, Raghava MV, Prabhakaran V, Oommen A, Muliyil J. Active epilepsy as an index of burden of neurocysticercois in Vellore district, India. Neurology 2006;67:2135-9.  Back to cited text no. 46
Sridharan R, Murthy BN. Prevalence and pattern of epilepsy in India. Epilepsia 1999;40:631-6.  Back to cited text no. 47
Li SC, Schoenberg BS, Wang CC, Cheng XM, Zhou SS, Bolis CL. Epidemiology of epilepsy in urban areas of People′s Republic of China. Epilepsia 1985;26:391-4.  Back to cited text no. 48
Wang WZ, Wu JZ, Wang DS, Dai XY, Yang B, et al. The prevalence and treatment gap in epilepsy in China. An ILAE/IBE/WHO study. Neurology 2003;60:1544-5.  Back to cited text no. 49
Aziz H, Guvener A, Akhtar SW, Hasan KZ. Comparative epidemiology of epilepsy in Pakistan and Turkey: Population-based studies using identical protocols. Epilepsia 1997;38:716-22.  Back to cited text no. 50
Senanayake N, Roman GC. Epidemiology of epilepsy in developing countries. Bull World Health Organ 1993;71:247-58.  Back to cited text no. 51
Aziz H, Ali SM, Frances P, Khan MI, Hasan KZ. Epilepsy in Pakistan: A population based epidemiological study. Epilepsia 1994;35:950-8.  Back to cited text no. 52
Rwiza HT, Kilonzo GP, Haule J, Matuja WB, Mteza I, Mbena P, et al. Prevalence and incidence of epilepsy in Ulanga, a rural Tanzanian district: A community-based study. Epilepsia 1992;33:1051-6.  Back to cited text no. 53
Saha SP, Bhattacharya S, Roy BK, Basu A, Roy T, Maity B, et al. A prospective incidence study of epilepsy in a rural community of West Bengal, India. Neurology Asia 2008;13:41-8.  Back to cited text no. 54
Banerjee TK, Ray BT, Das SK, Hazra A, Ghosal MK, Chaudhuri A, et al. A longitudinal study of epilepsy in Kolkata, India. Epilepsia 2010;51:2384-91.  Back to cited text no. 55
Hauser WA, Hesdorffer DC. Epidemiology of epilepsy. In: Anderson DW, editor. Neuroepidemiology: A tribute to Bruce Schoenberg. Boca Raton: CRC Press; 1991. p. 97-119.  Back to cited text no. 56
Houinato D, Yemadje LP, Glitho G, Adjien C, Avode G, Druet-Cabanac M, et al. Epidemiology of epilepsy in rural Benin: Prevalence, incidence, mortality, and follow-up. Epilepsia 2013;54:757-63.  Back to cited text no. 57
Ngugi AK, Bottomley C, Scott AG, Mung′ala-Odera V, Bauni E, Sander JW, et al. Incidence of convulsive epilepsy in a rural area in Kenya. Epilepsia 2013;54:1352-9.  Back to cited text no. 58
Medina MT, Duron RM, Martinez L, Osorio JR, Estrada AL, Zuniga C, et al. Prevalence, incidence and etiology of epilepsies in rural Honduras: The Salama Study. Epilepsia 2005;46:124-31.  Back to cited text no. 59
Shorvon SD, Farmer PJ. Epilepsy in developing countries: A review of epidemiological, sociocultural, and treatment aspects. Epilepsia 1988;29:S36-54.  Back to cited text no. 60
Gourie-Devi M, Satishchandra P, Gururaj G. Epilepsy control program in India: A district model. Epilepsia 2003;44:58-62.  Back to cited text no. 61
Meyer A, Dua T, Ma J, Saxena S, Birbeck G. Global disparities in the epilepsy treatment gap: A systematic review. Bull World Health Organ 2010;88:260-6.  Back to cited text no. 62
Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global burden of disease study. Lancet 1997;349:1269-76.  Back to cited text no. 63
Dalal PM. Burden of stroke: Indian perspective. Int J Stroke 2006;1:164-6.  Back to cited text no. 64
Bansal BC, Dhamija RK. Epidemiology of stroke in Haryana (North India). In: Bansal BC, Agarwal AK, editors. Recent concepts in stroke. New Delhi: Indian College of Physicians, Association of Physicians of India; 1999. p. 22-5.  Back to cited text no. 65
Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov VE, Strasser T. Cerebrovascular disease in the community: Results of WHO collaborative study. Bull World Health Organ 1980;58:113-30.  Back to cited text no. 66
Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Prevalence of stroke in the Parsi community of Bombay. Stroke 1988;19:60-2.  Back to cited text no. 67
Razdan S, Kaul RL, Motta A, Kaul S. Cerebrovascular disease in rural Kashmir, India. Stroke 1989;20:1691-3.  Back to cited text no. 68
Banerjee TK, Mukherjee CS, Sarkhel A. Stroke in the urban population of Calcutta -- An epidemiological study. Neuroepidemiology 2001;20:201-7.  Back to cited text no. 69
Das SK, Banerjee TK, Biswas A, Roy T, Raut DK, Mukherjee CS, et al. A prospective community-based study of stroke in Kolkata, India. Stroke 2007;38:906-10.  Back to cited text no. 70
Kulshreshtha A, Anderson LM, Goyal A, Keenan NL. Stroke in South Asia: A systematic review of epidemiologic literature from 1980 to 2010. Neuroepidemiology 2012;38:123-9.  Back to cited text no. 71
Shah B, Kumar N, Khurana S. Assessment of burden of non-communicable diseases. Indian Council of Medical Research; 2006. p. 154.  Back to cited text no. 72
Indrayan A. Forecasting vascular disease cases and associated mortality. Burden of disease in India. National Commission on Macroeconomics and Health, Ministry of Health and Family Welfare, Government of India, New Delhi; 2005. p. 197-218.  Back to cited text no. 73
Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: Epidemiology, prevention, and management strategies. Lancet Neurol 2007;6:456-64.  Back to cited text no. 74
Sridharan SE, Unnikrishnan JP, Sukumaran S, Sylaja PN, Nayak SD, Sarma PS, et al. Incidence, types, risk factors and outcome of stroke in a developing country: The Trivandrum stroke registry. Stroke 2009;40:1212-8.  Back to cited text no. 75
Dalal PM, Malik S, Bhattacharjee M, Trivedi ND, Vairale J, Bhat P, et al. Population-based stroke survey in Mumbai, India: Incidence and 28-day case fatality. Neuroepidemiology 2008;31:254-61.  Back to cited text no. 76
Jiang B, Wang WZ, Chen H, Hong Z, Yang QD, Wu SP, et al. Incidence and trends of stroke and its subtypes in China: Results from three large cities. Stroke 2006;37:63-8.  Back to cited text no. 77
Feigin VL, Lawes CM, Bennet DA, Andersen CS. Stroke epidemiology: A review of population based studies of incidence, prevalence, and case-fatality in the late 20 th century. Lancet Neurol 2003;2:43-53.  Back to cited text no. 78
Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennet DA, et al. Global and regional burden of stroke during 1990-2010: Findings from the global burden of disease study 2010. Lancet 2014;383:245-55.  Back to cited text no. 79
Truelsen T, Bonita R, Jamrozik K. Surveillance of stroke: A global perspective. Int J Epidemiol 2001;30:S11-6.  Back to cited text no. 80
Bonita R, Mendis S, Truelsen T, Bogousslavsky J, Toole J, Yatsu F. The global stroke initiative. Lancet Neurol 2004;3:391-3.  Back to cited text no. 81
Truelsen T, Heuschmann PU, Bonita R, Arjundas G, Dalal P, Damasceno A, et al. Standard method for developing stroke registers in low-income and middle-income countries: Experiences from a feasibility study of stepwise approach to stroke surveillance (STEPS stroke). Lancet Neurol 2007;6:134-9.  Back to cited text no. 82
Nagaraja D, Gururaj G, Girish N, Panda S, Roy AK, Sarma GR, et al. Feasibility study of stroke surveillance: Data from Bangalore, India. Indian J Med Res 2009;130:396-403.  Back to cited text no. 83
[PUBMED]  Medknow Journal  
Dalal PM, Shenoy A. Stroke epidemic in India - time to prioritize prevention strategies. J Assoc Physician India 2013;61:693-5.  Back to cited text no. 84
Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Case-control study of completed ischemic stroke in Parsis of Bombay: A population based study. Neurology 1988;38:490-2.  Back to cited text no. 85
Gupta R. Trends in hypertension epidemiology in India. J Hum Hypertens 2004;18:73-8.  Back to cited text no. 86
Joshi R, Cardona M, Iyengar S, Sukumar A, Raju CR, Raju KR, et al. Chronic diseases now a leading cause of death in rural India-mortality data from the Andhra Pradesh rural health initiative. Int J Epidemiol 2006;35:1522-9.  Back to cited text no. 87
Ray BK, Hazra A, Ghosal M, Banerjee T, Chaudhuri A, Singh V, et al. Early and delayed fatality of stroke in Kolkata, India: Results from a 7-year longitudinal population-based study. J Stroke Cerebrovasc Dis 2013;22:281-9.  Back to cited text no. 88
Goyal A, Yusuf S. The burden of cardiovascular disease in the Indian subcontinent. Indian J Med Res 2006;124:235-44.  Back to cited text no. 89
[PUBMED]  Medknow Journal  
Dalal PM, Bhattacharjee M. Stroke epidemic in India: Hypertension-stroke control programme is urgently needed. J Assoc Physician India 2007;55:689-91.  Back to cited text no. 90
Sethi NK, Kotwal A. National program for prevention and control of diabetes, cardiovascular disease (CVDs) and stroke. Focus on: Integrated strategies for prevention and control of hypertension at the level of primary and secondary health care. Ann Natl Acad Med Sci (India) 2009;45:307-24.  Back to cited text no. 91
Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Prevalence of Parkinson′s disease in the Parsi community of Bombay, India. Arch Neurol 1988;45:1321-3.  Back to cited text no. 92
Das SK, Misra AK, Ray BK, Hazra A, Ghosal MK, Chaudhuri A, et al. Epidemiology of Parkinson′s disease in the city of Kolkata, India: A community-based study. Neurology 2010;75:1362-9.  Back to cited text no. 93
MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain 2000;123:665-76.  Back to cited text no. 94
Harada H, Nishikawa S, Takahashi K. Epidemiology of Parkinson′s disease in a Japanese city. Arch Neurol 1983;40:151-4.  Back to cited text no. 95
Rajput AH, Offord KP, Beard CM, Kurland IT. Epidemiology of parkinsonism: Incidence, classification and mortality. Ann Neurol 1984;16:278-82.  Back to cited text no. 96
Li S, Schoenberg BS, Wang CC, Cheng XM, Rui Dy, Bolis CL, et al. A prevalence survey of Parkinson′s disease and other movement disorders in the People′s Republic of China. Arch Neurol 1985;42:655-7.  Back to cited text no. 97
Wang SJ, Fuh JL, Teng EL, Liu CY, Lin KP, Chen HM, et al. A door-to-door survey of Parkinson′s disease in Chinese population in Kinmen. Arch Neurol 1996;53:66-71.  Back to cited text no. 98
Anderson DW, Rocca WA, de Rijk MC, Grigoletto F, Melcon MO, Breteler MM, et al. Case ascertainment uncertainties in prevalence surveys of Parkinson′s disease. Mov Disord 1998;13:626-32.  Back to cited text no. 99
Muthane UB, Ragothaman M, Gururaj G. Epidemiology of Parkinson′s disease and movement disorders in India: Problems and possibilities. J Assoc Physicians India 2007;55:719-24.  Back to cited text no. 100
Sarangmath N, Rattihalli R, Ragothaman M, Gopalkrishna G, Doddaballapur S, Louis ED, et al. Validity of a modified Parkinson′s disease screening questionnaire in India: Effects of literacy of participants and medical training of screeners and implications for screening efforts in developing countries. Mov Disord 2005;20:1550-6.  Back to cited text no. 101
Ragothaman M, Murgod UA, Gururaj G, Kumaraswamy SD, Muthane U. Lower risk of Parkinson′s disease in an admixed population of European and Indian origins. Mov Disord 2003;18:912-4.  Back to cited text no. 102
Tan LC, Venkatasubramanian N, Hong CY, Sahadevan S, Chin JJ, Krishnamoorthy ES, et al. Prevalence of Parkinson disease in Singapore: Chinese vs Malays vs Indians. Neurology 2004;62:1999-2004.  Back to cited text no. 103
Chen CC, Chen TF, Hwang YC, Wen YR, Chiu YH, Wu CY, et al. Different prevalence rates of Parkinson′s disease in urban and rural areas: A population-based study in Taiwan. Neuroepidemiology 2009;33:350-7.  Back to cited text no. 104
Zhang ZX, Roman GC. Worldwide occurrence of Parkinson′s disease: An updated review. Neuroepidemiology 1993;12:195-208.  Back to cited text no. 105
Zhang ZX, Roman GC, Hong Z, Wu CB, Qu QM, Huang JB, et al. Parkinson′s disease in China: Prevalence in Biejing, Xian and Shanghai. Lancet 2005;365:595-7.  Back to cited text no. 106
Marras C, Tanner CM. Epidemiology of Parkinson′s disease. In: Watts RL, Koller WC, editors. Movement disorders: Neurologic principles and practice. 2 nd ed.. New York: McGraw-Hill Medical Publishing; 2004. p. 177-96.  Back to cited text no. 107
Muthane U, Yasha TC, Shankar SK. Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann Neurol 1998;43:283-7.  Back to cited text no. 108
Alladi PA, Mahadevan A, Yasha TC, Raju TR, Shankar SK, Muthane U. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson′s disease. Neuroscience 2009;159:236-45.  Back to cited text no. 109
Ragothaman M, Murgod UA, Gururaj G, Louis ED, Subbakrishna DK, Muthane UB. High occurrence and low recognition of Parkinsonism (and possible PD) in old age homes in Bangalore, South India. J Assoc Physician India 2008;56:233-6.  Back to cited text no. 110
Behari M, Srivastava AK, Das RR, Pandey RM. Risk factors of Parkinson′s disease in Indian patients. J Neurol Sci 2001;190:49-55. Sanyal J, Chakraborty DP, Sarkar B, Banerjee TK, Mukherjee C, Ray BC, et al. Environmental and familial risk factors of Parkinson′s disease: Case-control study.   Back to cited text no. 111
Sanyal J, Chakraborty DP, Sarkar B, Banerjee TK, Mukherjee C, Ray BC, et al. Environmental and familial risk factors of Parkinson's disease: Case‑control study. Can J Neurol Sci 2010;37:637‑42.  Back to cited text no. 112
Wang WZ, Fang XH, Cheng XM, Jiang DH, Lin ZJ. A case-control study on the environmental risk factors of Parkinson′s disease in Tianjin, China Neuroepidemiology 1993;12:209-18.  Back to cited text no. 113
Das SK, Banerjee TK, Roy T, Raut DK, Chaudhuri A, Hazra A. Prevalence of essential tremor in the city of Kolkota, India: A house-to-house survey. Eur J Neurol 2009;16:801-7. Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS.  Back to cited text no. 114
Prevalence of essential tremor in the Parsi community of Bombay, India. Arch Neurol 1988;45:907-8.  Back to cited text no. 115
Dotchin CL, Walker RW. The prevalence of essential tremor in rural northern Tanzania. J Neurol Neurosurg Psychiatry 2008;79:1107-9.  Back to cited text no. 116
Tan LC, Venkatasubramanian N, Ramasamy V, Gao W, Saw SM. Prevalence of essential tremor in Singapore: A study on three races in an Asian country. Parkinsonism Relat Disord 2005;11:233-9.  Back to cited text no. 117
Gourie-Devi M. Organization of neurology services in India: Unmet needs and the way forward. Neurol India 2008;56:4-12.  Back to cited text no. 118
[PUBMED]  Medknow Journal  
Mani KS, Rangan G, Srinivas HV, Srindharan VS, Subbakrishna DK. Epilepsy control with phenobarbital or phenytoin in rural south India: The Yelandur study. Lancet 2001;357:1316-20.  Back to cited text no. 119
Gourie-Devi M, Satishchandra P, Gururaj G. Delivery of epilepsy care to the community: Towards the national epilepsy control programme. Mental Health An Indian perspective 1946-2003. In: Agarwal SP, Goel DS, Salhan RN, Ichhpujani RL, Shrivastava S, editors. Directorate general of health services, Ministry of health and family welfare New Delhi; 2004. p. 295-305.  Back to cited text no. 120
Tripathi M, Jain DC, Devi MG, Jain S, Saxena V, Chandra PS, et al. Need for a national epilepsy control program. Ann Indian Acad Neurol 2012;15:89-93.  Back to cited text no. 121
[PUBMED]  Medknow Journal  
Mehndiratta MM, Khan M, Mehndiratta P, Wassay M. Stroke in Asia: Geographical variations and temporal trends. J Neurol Neurosurg Psychiatry 2014;85:1308-12.  Back to cited text no. 122
Langhorne P, de Villiers L, Pandian JD. Applicability of stroke-unit care to low-income and middle-income countries. Lancet Neurol 2012;11:341-8.  Back to cited text no. 123


  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]

This article has been cited by
1 In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer’s disease
Sundas Firdoos, Rongji Dai, Rana Adnan Tahir, Zahid Younas Khan, Hui Li, Jun Zhang, Junjun Ni, Zhenzhen Quan, Hong Qing
Journal of Molecular Modeling. 2023; 29(7)
[Pubmed] | [DOI]
2 Performance evaluation of an indigenously-designed high performance dynamic feeding robotic structure using advanced additive manufacturing technology, machine learning and robot kinematics
Priyam Parikh, Ankit Sharma, Reena Trivedi, Debanik Roy, Keyur Joshi
International Journal on Interactive Design and Manufacturing (IJIDeM). 2023;
[Pubmed] | [DOI]
3 Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP
Haorei Yarreiphang, D J Vidyadhara, Anand Krishnan Nambisan, Trichur R Raju, BK Chandrashekar Sagar, Phalguni Anand Alladi
Molecular Neurobiology. 2023;
[Pubmed] | [DOI]
4 Drug Utilization Evaluation of Medications Used in the Management of Neurological Disorders
Meghana Upadhya, Nivya Jimmy, Jesslyn Maria Jaison, Shahal Sidheque, Harsha Sundaramurthy, S C Nemichandra, Shasthara Paneyala, Madhan Ramesh, Sri Harsha Chalasani, Jehath Syed, Nikita Pal
Global Health Journal. 2023;
[Pubmed] | [DOI]
5 A clinical pharmacist integrated approach in assessing the rate and pattern of drug related problems in patients with neurological disorders: A multidisciplinary collaborative approach
Nivya Jimmy, Meghana Upadhya, Jesslyn Maria Jaison, Shahal Sidheque, Harsha Sundaramurthy, S.C. Nemichandra, Shasthara Paneyala, Madhan Ramesh, Sri Harsha Chalasani, Jehath Syed, Nikita Pal
Exploratory Research in Clinical and Social Pharmacy. 2023; : 100302
[Pubmed] | [DOI]
6 Conceptualizing a Rehabilitation ‘Model of Care’ for Improving the Quality of Life of People with Parkinson’s in India
Maria Barretto, Nicole D’souza
Annals of Indian Academy of Neurology. 2023; 26(4): 387
[Pubmed] | [DOI]
7 Major neurological disorders in tribal areas of Himachal Pradesh: A community-based survey
Ashok Bhardwaj, Sunil Raina, Sanjay Kumar, Mitasha Singh, Dinesh Kumar, Piyush Sharma
Indian Journal of Health Sciences and Biomedical Research (KLEU). 2022; 15(1): 57
[Pubmed] | [DOI]
8 A modern history of neurosurgery and neurology in India: lessons for the world
Anurag Modak, Bharath Raju, Fareed Jumah, Margaret Pain, Gaurav Gupta, Anil Nanda
Journal of Neurosurgery. 2022; : 1
[Pubmed] | [DOI]
A. Brindha, K.A. Sunitha, S. Robert Wilson
IOP Conference Series: Materials Science and Engineering. 2022; 1219(1): 012024
[Pubmed] | [DOI]
10 What are the challenges with multi-targeted drug design for complex diseases?
Agata Zieba, Piotr Stepnicki, Dariusz Matosiuk, Agnieszka A. Kaczor
Expert Opinion on Drug Discovery. 2022; : 1
[Pubmed] | [DOI]
11 Knowledge, Attitude, and Practice of epilepsy in Wayanad, Kerala
Sachin Sureshbabu, Hisham Moosan, Merisin Joseph, C.V. Haseena, R. Lekshmi, Aleema Naz, V.P. Muralikrishnan, Smilu Mohanlal, Paul J. Alappat, V.P. Tushar, Dinesh Nayak
Epilepsy & Behavior. 2022; : 108762
[Pubmed] | [DOI]
12 Novel Inflammasome and Oxidative Modulators in Parkinson’s Disease: A Prospective Study
Akash Roy, Rebecca Banerjee, Supriyo Choudhury, Koustav Chatterjee, Banashree Mondal, Sanjit Dey, Hrishikesh Kumar
Neuroscience Letters. 2022; : 136768
[Pubmed] | [DOI]
13 “Patterns of occurrence and management abilities of birth defects: A study from a highly urbanized coastal district of India”
Koteswara Rao Pagolu, Raghava Rao Tamanam
Clinical Epidemiology and Global Health. 2022; : 101062
[Pubmed] | [DOI]
14 Evaluation of Gait Termination Strategy in Individuals with Essential Tremor and Parkinson's disease
Jared W. Skinner, Hyo Keun Lee, Chris J. Hass
Gait & Posture. 2021;
[Pubmed] | [DOI]
15 Metabolomics of neurological disorders in India
Sangeetha Gupta, Uma Sharma
Analytical Science Advances. 2021;
[Pubmed] | [DOI]
16 Association of HLA–DRB1, DQA1 and DQB1 alleles and haplotype in Parkinson’s disease from South India
Sasiharan Pandi, Rathika Chinniah, Vandit Sevak, Padma Malini Ravi, Muthuppandi Raju, Neethi Arasu Vellaiappan, Balakrishnan Karuppiah
Neuroscience Letters. 2021; 765: 136296
[Pubmed] | [DOI]
17 Neurological disorders in India: past, present, and next steps
Man Mohan Mehndiratta, Vasundhara Aggarwal
The Lancet Global Health. 2021; 9(8): e1043
[Pubmed] | [DOI]
18 Hypoxic Preconditioning Induces Neuronal Differentiation of Infrapatellar Fat Pad Stem Cells through Epigenetic Alteration
Subathra Radhakrishnan, Catherine Ann Martin, Geethanjali Dhayanithy, Mettu Srinivas Reddy, Mohamed Rela, Subbaraya Narayana Kalkura, Shanmugaapriya Sellathamby
ACS Chemical Neuroscience. 2021; 12(4): 704
[Pubmed] | [DOI]
19 The development and efficacy of a mobile phone application to improve medication adherence for persons with epilepsy in limited resource settings: A preliminary study
Pranav Mirpuri, P. Prarthana Chandra, Raghu Samala, Mohit Agarwal, Ramesh Doddamani, Kirandeep Kaur, Bhargavi Ramanujan, P. Sarat Chandra, Manjari Tripathi
Epilepsy & Behavior. 2021; 116: 107794
[Pubmed] | [DOI]
20 An overview on therapeutic and medicinal potential of poly-hydroxy flavone viz. Heptamethoxyflavone, Kaempferitrin, Vitexin and Amentoflavone for management of Alzheimer’s and Parkinson’s diseases: a critical analysis on mechanistic insight
Mansi Varshney, Bhavna Kumar, Vijay Singh Rana, Neeraj K. Sethiya
Critical Reviews in Food Science and Nutrition. 2021; : 1
[Pubmed] | [DOI]
21 Risk factors predisposing to acute stroke in India: a prospective study
C. Venkata S. Ram, Sudhir Kumar, Pushpendra Nath Renjen, G. Praveen Kumar, Jayanthi Swaminathan, C. Rajesh Reddy, Sathyanarayana Kondati, Mukesh Sharma, V.L. Arul Selvan, Meenakshi Sundaram, Anupama Vasudevan, Daniel Lackland
Journal of Hypertension. 2021; 39(11): 2183
[Pubmed] | [DOI]
22 The role of the P2X4 receptor in trigeminal neuralgia, a common neurological disorder
Ming-Xin Lu, Zeng-Xu Liu
NeuroReport. 2021; Publish Ah
[Pubmed] | [DOI]
23 Recalling the pathology of Parkinson's disease; lacking exact figure of prevalence and genetic evidence in Asia with an alarming outcome: A time to step-up
Arif Mahmood, Abid Ali Shah, Muhammad Umair, Yiming Wu, Amjad Khan
Clinical Genetics. 2021; 100(6): 659
[Pubmed] | [DOI]
24 The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019
Gagandeep Singh, Meenakshi Sharma, G Anil Kumar, N Girish Rao, Kameshwar Prasad, Prashant Mathur, Jeyaraj D Pandian, Jaimie D Steinmetz, Atanu Biswas, Pramod K Pal, Sanjay Prakash, P N Sylaja, Emma Nichols, Tarun Dua, Harkiran Kaur, Suvarna Alladi, Vivek Agarwal, Sumit Aggarwal, Atul Ambekar, Bhavani S Bagepally, Tapas K Banerjee, Rose G Bender, Sadhana Bhagwat, Stuti Bhargava, Rohit Bhatia, Joy K Chakma, Neerja Chowdhary, Subhojit Dey, M Ashworth Dirac, Valery L Feigin, Atreyi Ganguli, Mahaveer J Golechha, M Gourie-Devi, Vinay Goyal, Gaurav Gupta, Prakash C Gupta, Rajeev Gupta, Gopalkrishna Gururaj, Rajkumar Hemalatha, Panniyammakal Jeemon, Catherine O Johnson, Pradeep Joshi, Rajni Kant, Amal C Kataki, Dheeraj Khurana, Rinu P Krishnankutty, Hmwe H Kyu, Stephen S Lim, Rakesh Lodha, Rui Ma, Rajesh Malhotra, Ridhima Malhotra, Matthews Mathai, Ravi Mehrotra, Usha K Misra, Parul Mutreja, Mohsen Naghavi, Nitish Naik, Minh Nguyen, Anamika Pandey, Priya Parmar, Arokiasamy Perianayagam, Dorair
The Lancet Global Health. 2021; 9(8): e1129
[Pubmed] | [DOI]
25 Good Death in Neurological Practice
Krishnan Ganapathy
Neurology India. 2021; 69(4): 792
[Pubmed] | [DOI]
26 Epidemiology of Parkinson’s Disease in Rural Gujarat, India
Goun Je, Swati Arora, Shyamsundar Raithatha, Ryan Barrette, Navid Valizadeh, Utkarsh Shah, Devangi Desai, Anindita Deb, Soaham Desai
Neuroepidemiology. 2021; 55(3): 188
[Pubmed] | [DOI]
27 Chronic Neurological Disorders: Genetic and Epigenetic Markers for Monitoring of Pharmacotherapy
SudhirChandra Sarangi, Pranav Sopory, KH Reeta
Neurology India. 2021; 69(2): 252
[Pubmed] | [DOI]
28 Oral health status of people with locomotor disability in India: A systematic review
Lakshmi Krishnan, ParangimalaiDivakar Madankumar
Scientific Dental Journal. 2021; 5(1): 12
[Pubmed] | [DOI]
29 A Collaborative Tele-Neurology Outpatient Consulation Service in Karnataka: Seven Years of Experience From a Tele-Medicine Center
GuruS Gowda, Narayana Manjunatha, Karishma Kulkarni, VirupakshappaIrappa Bagewadi, RPS Shyam, Vinay Basavaraju, ManjunathaB Ramesh, ShashidharaHarihara Nagabhushana, ChannaveerachariNaveen Kumar, GirishBaburao Kulkarni, SureshBada Math
Neurology India. 2020; 68(2): 358
[Pubmed] | [DOI]
30 Altered plasma prostaglandin E2 levels in epilepsy and in response to antiepileptic drug monotherapy
Chitra Rawat, Shivangi, Suman Kushwaha, Sangeeta Sharma, Achal K Srivastava, Ritushree Kukreti
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2020; 153: 102056
[Pubmed] | [DOI]
31 Polycomb repressive complex 1: Regulators of neurogenesis from embryonic to adult stage
Divya Desai, Prasad Pethe
Journal of Cellular Physiology. 2020; 235(5): 4031
[Pubmed] | [DOI]
32 Nexus between light and culture media on morphogenesis in Bacopa monnieri and saponin yield thereof
Akanksha Aggarwal, Ashwani Mathur
Heliyon. 2020; 6(10): e05245
[Pubmed] | [DOI]
33 Stroke Happens Suddenly so It Cannot Be Prevented: A Qualitative Study to Understand Knowledge, Attitudes, and Practices about Stroke in Rural Gadchiroli, Maharashtra, India
Yogeshwar Kalkonde, Sona Deshmukh, Charuta Gokhale, Mini Jacob, Abhay Bang
Journal of Neurosciences in Rural Practice. 2020; 11: 53
[Pubmed] | [DOI]
34 Yoga as a holistic approach for stress management in Oral Cancer patients. A prospective study
SamarjeetJ Pattnaik, RajKishore Prasad, Jyo Jyotirmay, Pooja Pani, Nis Nishant, Swatantra Kumar
Journal of Family Medicine and Primary Care. 2020; 9(8): 4200
[Pubmed] | [DOI]
35 Prevalence of major neurological disorders in predominantly rural northwest India
ManojK Gandhi, SunilK Raina, Amit Bhardwaj, Abhilash Sood
Journal of Family Medicine and Primary Care. 2020; 9(9): 4627
[Pubmed] | [DOI]
36 Parkinson’s Disease in the Middle East, North Africa, and South Asia: Consensus from the International Parkinson and Movement Disorder Society Task Force for the Middle East
Hanan Khalil, Lana M. Chahine, Junaid Siddiqui, Mehri Salari, Shaimaa El-Jaafary, Zakiyah Aldaajani, Mishal Abu Al-Melh, Tareq Mohammad Mohammad, Muneer Abu Snineh, Nadir A. Syed, Mohit Bhatt, Mohammad Ahsan Habib, Majed Habahbeh, Samer D. Tabbal, Beomseok Jeon, Jawad A. Bajwa
Journal of Parkinson's Disease. 2020; 10(2): 729
[Pubmed] | [DOI]
37 Long-Term Study about the Incidence of Epilepsy in Male Service Personnel from India: A Retrospective, Cohort Study
Pawan Dhull, S. K. Patnaik, Manoj Somasekharan, K. V. S Hari Kumar
Journal of Neurosciences in Rural Practice. 2019; 10: 588
[Pubmed] | [DOI]
38 The Evolving Neural Tissue Engineering Landscape of India
Swati Haldar, Souvik Ghosh, Viney Kumar, Partha Roy, Debrupa Lahiri
ACS Applied Bio Materials. 2019; 2(12): 5446
[Pubmed] | [DOI]
39 Research on the cause of death for severe stroke patients
Mei-zhen Yuan,Feng Li,Qin Fang,Wei Wang,Jing-jing Peng,De-yu Qin,Xue-feng Wang,Guang-wei Liu
Journal of Clinical Nursing. 2018; 27(1-2): 450
[Pubmed] | [DOI]
Prem Singh, Mainak Deb, Alok Verma, Ashok Kumar Verma, Rinkita Deb Ganguly
Journal of Evolution of Medical and Dental Sciences. 2018; 7(10): 1275
[Pubmed] | [DOI]
41 “Know About Palliative Care”
Dr. K Renuka, Mrs. V. Manopriya
Pondicherry Journal of Nursing. 2018; 11(1): 40
[Pubmed] | [DOI]
42 “Know About Palliative Care”
Dr. Renuka K, Mrs. V. Manopriya
Pondicherry Journal of Nursing. 2018; 14(1): 40
[Pubmed] | [DOI]
43 Appraisal of Transdermal Water-in-Oil Nanoemulgel of Selegiline HCl for the Effective Management of Parkinson’s Disease: Pharmacodynamic, Pharmacokinetic, and Biochemical Investigations
Sonal Setya,Tushar Madaan,Mohammad Tariq,B. K. Razdan,Sushama Talegaonkar
AAPS PharmSciTech. 2018; 19(2): 573
[Pubmed] | [DOI]
44 Neuroactive drugs–A perspective on drugs of synthetic and medicinal plants origin
Mohd. Farooq Shaikh, Alina Arulsamy, Yogini S Jaiswal, Bey Hing Goh, Saatheeyavaane Bhuvanendran, Thaarvena Retinasamy, Yatinesh Kumari, Iekhsan Othman, Leonard L Williams
Pharmacy & Pharmacology International Journal. 2018; 6(6)
[Pubmed] | [DOI]
45 Neurosurgery in India: Success and challenges
Ankit Raj, Amit Agrawal
International Journal of Academic Medicine. 2018; 4(1): 89
[Pubmed] | [DOI]
46 Association ofHelicobacter pyloriwith Parkinsonæs Disease
Kandadai Rukmini Mridula,Rupam Borgohain,Vupparalli Chandrasekhar Reddy,Venkata Chandrasekhar Srinivasarao Bandaru,Turaga Suryaprabha
Journal of Clinical Neurology. 2017; 13(2): 181
[Pubmed] | [DOI]
47 High Burden of Unrecognized Atrial Fibrillation in Rural India: An Innovative Community-Based Cross-Sectional Screening Program
Apurv Soni,Allison Earon,Anna Handorf,Nisha Fahey,Kandarp Talati,John Bostrom,Ki Chon,Craig Napolitano,Michael Chin,John Sullivan,Shyamsundar Raithatha,Robert Goldberg,Somashekhar Nimbalkar,Jeroan Allison,Sunil Thanvi,David McManus
JMIR Public Health and Surveillance. 2016; 2(2): e159
[Pubmed] | [DOI]
48 Perspectives on Translational Genomics and Public Health in India
Sanjiban Chakrabarty, Shama Prasada Kabekkodu, Angela Brand, Kapaettu Satyamoorthy
Public Health Genomics. 2016; 19(2): 61
[Pubmed] | [DOI]
49 Differential expression of calbindin in nigral dopaminergic neurons in two mice strains with differential susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
D.J. Vidyadhara,H. Yarreiphang,P.L. Abhilash,T.R. Raju,Phalguni Anand Alladi
Journal of Chemical Neuroanatomy. 2016;
[Pubmed] | [DOI]
50 NAMASTE for stroke awareness
Shriram Varadharajan
Neurology India. 2015; 63(4): 633
[Pubmed] | [DOI]


Print this article  Email this article
Online since 20th March '04
Published by Wolters Kluwer - Medknow