|Year : 2016 | Volume
| Issue : 2 | Page : 361-362
Department of Neurology, Christian Medical College, Vellore, Tamil Nadu - 632 004, India
|Date of Web Publication||3-Mar-2016|
Department of Neurology, Christian Medical College, Vellore, Tamil Nadu - 632 004
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Alexander M. Author's reply. Neurol India 2016;64:361-2
The authors read with keen interest the letter to the editor and thank the authors for the valuable comments.
Regarding the natural history of the disease, because of ethical issues, it is no longer possible to study the natural history of untreated disease in a sizable sample. Further, it is equally important to know the natural history of multiple sclerosis treated by various interventions. The course and outcome is likely to fall into more than one pattern that might have a bearing on the overall disability or quality of life.
The next best option would be a population based cohort study like the Canadian or North American multiple sclerosis registry or a hospital based prospective study. [1,2] This paper belongs to this category and the design of the study is quite robust.
The term 'incidence' was used in a non-technical manner to describe the proportions rather than the new cases over a specific period of time (incidence) or number of cases at a given point of time (prevalence).
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Conflicts of interest
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