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Table of Contents    
Year : 2016  |  Volume : 64  |  Issue : 2  |  Page : 361-362

Author's reply

Department of Neurology, Christian Medical College, Vellore, Tamil Nadu - 632 004, India

Date of Web Publication3-Mar-2016

Correspondence Address:
Mathew Alexander
Department of Neurology, Christian Medical College, Vellore, Tamil Nadu - 632 004
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Source of Support: None, Conflict of Interest: None

PMID: 26954832

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How to cite this article:
Alexander M. Author's reply. Neurol India 2016;64:361-2

How to cite this URL:
Alexander M. Author's reply. Neurol India [serial online] 2016 [cited 2021 Jun 20];64:361-2. Available from:

Dear Sir,

The authors read with keen interest the letter to the editor and thank the authors for the valuable comments.

Regarding the natural history of the disease, because of ethical issues, it is no longer possible to study the natural history of untreated disease in a sizable sample. Further, it is equally important to know the natural history of multiple sclerosis treated by various interventions. The course and outcome is likely to fall into more than one pattern that might have a bearing on the overall disability or quality of life.

The next best option would be a population based cohort study like the Canadian or North American multiple sclerosis registry or a hospital based prospective study. [1,2] This paper belongs to this category and the design of the study is quite robust.[3]

The term 'incidence' was used in a non-technical manner to describe the proportions rather than the new cases over a specific period of time (incidence) or number of cases at a given point of time (prevalence).

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Conflicts of interest

There are no conflicts of interest.

 » References Top

Hurwitz BJ. Registry studies of long term multiple sclerosis outcomes. Neurology 2011:76(Suppl1):S3-6.  Back to cited text no. 1
Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy JH, et al. Disability profile of multiple sclerosis did not change over 10 years in a population based prevalence cohort. Neurology 2004;62:601-6.  Back to cited text no. 2
Jena SS, Alexander M, Aaron S, Mathew V, Thomas MM, Patil AK, et al. Natural history of multiple sclerosis from the Indian perspective: Experience from a tertiary care hospital. Neurol India 2015;63:866-73.  Back to cited text no. 3
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