| Article Access Statistics|
| Viewed||2041 |
| Printed||22 |
| Emailed||0 |
| PDF Downloaded||56 |
| Comments ||[Add] |
Click on image for details.
|Year : 2016 | Volume
| Issue : 4 | Page : 841-842
Achalasia and amyotrophic lateral sclerosis as part of Allgrove syndrome
Gourav Jain, Aditya Choudhary, Manoj Goyal, Vivek Lal
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
|Date of Web Publication||5-Jul-2016|
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Jain G, Choudhary A, Goyal M, Lal V. Achalasia and amyotrophic lateral sclerosis as part of Allgrove syndrome. Neurol India 2016;64:841-2
We have read the recently published manuscript written by Mahale et al., and appreciate the insight that the authors provide in considering alternate possibilities in patients presenting with dysphagia in limb onset amyotrophic lateral sclerosis. However, it is pertinent to note that upper and lower motor neuron involvement can be a presenting feature of Allgrove's syndrome. Allgrove or triple A syndrome is a rare autosomal recessive disease caused by a mutation in the gene encoding protein ALADIN, and though common in children, it can also present in adulthood. The syndrome is characterized by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction, and amyotrophy. We feel that it would be worthwhile to look for other symptoms of the triple A syndrome in the concerned patients such as alacrima and adrenal insufficiency.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| » References|| |
Mahale R, Mehta A, Kempegowda MB, Javali M, Rangasetty S. Achalasia cardia causing dysphagia in amyotrophic lateral sclerosis. Neurol India 2015;63:989-91.
Messina MF, Autunno M, Koehler K, Russo M, Arrigo T, Crisafulli G, et al.
Upper and lower motor neuron involvement as presenting manifestation of triple A syndrome. J Endocrinol Invest 2009;32:482-3.
Nakamura K, Yoshida K, Yoshinaga T, Kodaira M, Shimojima Y, Takei Y, et al.
Adult or late-onset triple A syndrome: Case report and literature review. J Neurol Sci 2010;297:85-8.
Vishnu VY, Modi M, Prabhakar S, Bhansali A, Goyal MK. “A” motor neuron disease. J Neurol Sci 2014;336:251-3.
Strauss M, Koehler K, Krumbholz M, Huebner A, Zierz S, Deschauer M. Triple A syndrome mimicking ALS. Amyotroph Lateral Scler 2008;9:315-7.