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Table of Contents    
Year : 2017  |  Volume : 65  |  Issue : 2  |  Page : 439-440

Neurological problem due to Zika virus infection: What should be discussed?

1 Medical Center, Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Tropical Medicine, Hainan Medical University, Haikou, China

Date of Web Publication10-Mar-2017

Correspondence Address:
Dr. Beuy Joob
Sanitation, 1 Medical Academic Center, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/neuroindia.NI_912_16

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How to cite this article:
Joob B, Wiwanitkit V. Neurological problem due to Zika virus infection: What should be discussed?. Neurol India 2017;65:439-40

How to cite this URL:
Joob B, Wiwanitkit V. Neurological problem due to Zika virus infection: What should be discussed?. Neurol India [serial online] 2017 [cited 2023 Feb 5];65:439-40. Available from: https://www.neurologyindia.com/text.asp?2017/65/2/439/201874


Hajra et al., published an interesting article on neurological problems due to Zika virus (ZIKV) infection.[1] The authors have discussed the various congenital neurological disorders occurring in infants born to ZIKV infected mothers and the increase in the incidence of Guillain Barre syndrome (GBS) among the infected cases. Hajra et al., also noted that “the atypical presentation may delay the diagnosis of ZIKV infection.”[1] We would like to share some ideas on this report. First, there is no doubt that the problem of congenital microcephaly is confirmed in the ZIKV outbreak in South America; however, the interesting question is why there has been no similar observation in Asia where the ZIKV infection outbreak has also occurred. Second, the increase in the incidence of GBS after ZIKV infection should be an immuno-pathological process. An interesting observation that is often made is that there is still no report on GBS in the ZIKV infected pregnant women. Whether or not there is any biological process of pregnancy that can act against the pathogenesis of GBS is an interesting question for further research. Finally, whether GBS is an atypical neurological presentation of ZIKV infection that might delay the establishment of a proper diagnosis should be further discussed. In fact, any viral infection might induce GBS, and this is not an uncommon problem in the tropical world. In the case of GBS caused by ZIKV infection, the patient may be diagnosed as having ZIKV infection when GBS sets in; however, this does not mean there is a delay in the diagnosis of ZIKV due to the presence of an atypical neurological manifestation because GBS is a post-infective sequel. The delayed diagnosis of ZIKV is usually due to an unawareness among the practitioners regarding the manifestations of ZIKV, due to the high similarity of the symptomatology of its infection to other tropical infections, especially dengue.[2] In fact, many cases of ZIKV can be asymptomatic, but this does not mean that GBS cannot occur in these cases.[3]

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 » References Top

Hajra A, Bandyopadhyay D, Hajra SK. Zika virus: New interest in Neurology. Neurol India 2016;64:1102-4.  Back to cited text no. 1
[PUBMED]  [Full text]  
Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health 2015;8:145-6.  Back to cited text no. 2
  [Full text]  
Wiwanitkit S, Wiwanitkit V. Afebrile, asymptomatic and non-thrombocytopenic Zika virus infection: Don't miss it! Asian Pac J Trop Med 2016;9:513.  Back to cited text no. 3


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