| NI FEATURE: NORMATIVE DATA - ORIGINAL ARTICLE
|Year : 2018 | Volume
| Issue : 1 | Page : 176--180
Auditory P300 event-related potential: Normative data in the Indian population
NA Uvais1, S Haque Nizamie2, Basudeb Das2, Samir K Praharaj3, Mohammad Zia Ul Haq Katshu4
1 Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India
2 Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India
3 Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India
4 Department of Psychiatry, Institute of Mental Health, University of Nottingham, UK
Objective: To generate the normative data of auditory P300 event-related potential for various age groups in the Indian population.
Materials and Methods: Auditory P300 event-related potentials, using the oddball paradigm, of healthy control participants in studies carried out at our institute were included to generate normative data in the age range of 10–50 years. The amplitude and latency of P300 for Fz, Cz, and Pz were selected for analysis.
Results: For P300 amplitude, overall multivariate analysis of variance (MANOVA) was significant [Pillai's Trace F (9/453) = 3.46, P < 0.001]. Follow-up ANOVA showed significant difference across age groups at Fz, Cz, and Pz. For P300 latency, there was a trend towards significance for overall MANOVA [Pillai's Trace F (9/453) = 1.68, P = 0.09]. Follow-up ANOVA showed a trend towards significant difference across age groups at Fz only.
Conclusion: Our study generated a P300 amplitude and frequency normative database at Fz, Cz, and Pz, which will serve as a reference for future studies attempting to define P300 abnormalities in various psychiatric disorders in Indian population.
Dr. N A Uvais
Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut - 673 009, Kerala
Source of Support: None, Conflict of Interest: None
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