Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 11956  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
  »  Article in PDF (558 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

  In this Article
 »  References
 »  Article Figures

 Article Access Statistics
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal


Table of Contents    
Year : 2018  |  Volume : 66  |  Issue : 7  |  Page : 152-154

Does cerebral infarction ameliorate essential tremor? A mini-review

Department of Neurology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India

Date of Web Publication1-Mar-2018

Correspondence Address:
Dr. Rohan Mahale
Department of Neurology, M.S Ramaiah Medical College and Hospital, Bangalore - 560 054, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.226462

Rights and Permissions

How to cite this article:
Mahale R, Mehta A, Shetty N, Srinivasa R. Does cerebral infarction ameliorate essential tremor? A mini-review. Neurol India 2018;66, Suppl S1:152-4

How to cite this URL:
Mahale R, Mehta A, Shetty N, Srinivasa R. Does cerebral infarction ameliorate essential tremor? A mini-review. Neurol India [serial online] 2018 [cited 2023 Dec 6];66, Suppl S1:152-4. Available from:


Essential tremors (ETs) are one of the commonest movement disorders. Tremors have been considered to be 'benign' but this nomenclature has been abandoned due to the emergence of recent evidence of the functional and psychological disabilities associated with ETs. However, ETs remain a poorly understood entity till date. There is a recent suggestion that ET may be a manifestation of a neurodegenerative disorder resulting in cognitive decline and cerebellar dysfunction apart from the classical postural and action arm tremors.[1] The occurrence of infarct in the precentral region, thalamus, striatum and cerebellum has been reported to ameliorate ETs in the contralateral limbs. We report a 55-year old male patient who had postural tremors in both his hands since the age of 20 years and had amelioration of tremors in his right hand following a left striato-capsular infarct.

A 55-year old male patient had a history of tremors of both his hands since the age of 20 years. Tremors were fine, symmetrical, involving both his hands, that appeared on maintaining posture against gravity and interfered with his writing. He had sudden-onset slurred speech with clumsiness in the right hand 1 month ago that improved within one week. Following this recovery, he noticed that tremors in his right hand had disappeared. He was hypertensive and was on medications. There were no other co-morbidities. His mother had a history of tremors in both her hands. On examination, he was conscious and oriented. There was no dysarthria. He had mild right pronator drift. He had postural tremors in the left upper limb only [Video 1]. There were no other neurological abnormalities. Complete hemogram, renal, liver and thyroid function tests were normal. Brain magnetic resonance imaging (MRI) showed a hyperintense lesion in the left striato-capsular region [Figure 1]. Carotid Doppler and two-dimensional transthoracic echocardiography were normal. He was started on propranolol and had improvement in his symptoms.
Figure 1: Brain MRI fluid attenuated inversion recovery image axial view showing hyperintensity in the left striato- capsular region due to the development of an infarct (arrow)

Click here to view

The pathogenesis of ETs is of a central origin. Aberrant oscillations in the olivo-cerebellar circuit have been implicated in the generation of abnormal rhythmic motor activity.[2] In patients with ETs, neurodegenerative changes have been seen in the cerebellum with a selective loss of Purkinje cells and signs of their axonal swelling and degeneration with formation of axonal torpedoes. Purkinje cells, Golgi interneurons and basket cells, as well as dentate nucleus (where the cerebellothalamic pathway originates) are GABA-ergic neurons and their intracerebellar output is inhibitory. Diminished cerebellar gamma-aminobutyric acid (GABA)-ergic tone causes reduced inhibitory cerebellar outflow with resulting excitatory cerebellar output.[3] Medically refractory ETs are being treated surgically by targeting the ventral intermediate nucleus (ViM) of the thalamus. Thalamic deep brain stimulation (DBS) has been used to disrupt the abnormal cerebellar-thalamic-cortical outflow that is hypothesized to be involved in the ET pathogenesis. Kim et al., (2006) reported a patient with essential tremors who spontaneously improved after a sensorimotor stroke related to a small cortical infarct near the left precentral region of the brain. They postulated the presence of cortical or transcortical motor loops that are likely to be involved in ETs and suggest a possible link with the cerebellar-thalamic-cortical pathway.[4]

There are reports of amelioration of ETs in the contralateral limb following occurrence of infarct in the precentral region, thalamus, pons, striatum and cerebellum. Dupuis et al., in 1989, reported a patient with ETs in whom tremors disappeared on the right side after a homolateral cerebellar infarct. They reported that vascular and surgical lesions of the dentorubrothalamic pathway improve various kinds of tremors including ETs.[5] Urushitani et al., in 1996, reported disappearance of essential neck tremors after a pontine base infarction.[6] Nakamura et al., in 1999, reported a patient with ETs wherein the tremors disappeared after a thalamic infarction.[7] Choi et al., in 2008 reported disappearance of resting tremors following a thalamic infarct in the tubero-thalamic territory.[8] Constantino et al., in 2003 reported the unilateral disappearance of ETs after the development of a cerebral hemispheric infarct.[9] Kim et al., in 2006, reported disappearance of writing tremors after a striatal infarction.[10] Chalah et al., in 2015 reported a patient with permanent reversal of essential tremors following a frontal lobe stroke. They postulated that the ischemic stroke could have interrupted the cortical component of the ET network, leading to the cessation of tremors.[11] Our patient had disappearance of right hand ETs following a left striato-capsular infarct. The amelioration may have been be due to the involvement of the cerebello-thalamo-cortical loop fibers traversing the internal capsule.[12]

Lesions anywhere in the cerebello-thalamo-cortical loops tend to ameliorate ETs in the ipsilateral or contralateral limbs. Lesions in the internal capsule also ameliorate ETs, as demonstrated in our patient.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

 » References Top

Benito-León J, Louis E. Essential tremor: Emerging views of a common disorder. Nat Clin Pract Neurol 2006;2:666-78.  Back to cited text no. 1
Lorenz D, Deuschl G. Update on pathogenesis and treatment of essential tremor. Curr Opin Neurol 2007;20:447-52.  Back to cited text no. 2
Hedera P. Emerging strategies in the manangement of essential tremor. Ther Adv Neurol Disord 2017;10:137-48.  Back to cited text no. 3
Kim JS, Park JW, Kim WJ, Kim HT, Kim YI, Lee KS. Disappearance of essential tremor after frontal cortical infarct. Mov Disord 2006;21:1284-5.  Back to cited text no. 4
Dupuis MJ, Delwaide PJ, Boucquey D, Gonsette RE. Homolateral disappearance of essential tremor after cerebellar stroke. Mov Disord 1989;4:183-7.  Back to cited text no. 5
Urushitani M, Inoue H, Kawamura K, Kageyama T, Fujisawa M, Nishinaka K, Udaka F, Kameyama M. Disappearance of essential neck tremor after pontine base infarction. No To Shinkei 1996;48:753-6.  Back to cited text no. 6
Nakamura Y, Miura K, Yamada I, Takada K. Disappearance of essential tremor after thalamic infarction. Rinsho Shinkeigaku 1999;39:340-2.  Back to cited text no. 7
Choi SM, Lee SH, Park MS, Kim BC, Kim MK, Cho KH. Disappearance of resting tremor after thalamic stroke involving the territory of the tuberothalamic artery. Parkinsonism Relat Disord 2008;14:373-5.  Back to cited text no. 8
Constantino AE, Louis ED. Unilateral disappearance of essential tremor after cerebral hemispheric infarct. J Neurol 2003;250:354-5.  Back to cited text no. 9
Kim DH, Kim J, Kim JM, Lee AY. Disappearance of writing tremor after striatal infarction. Neurology 2006 25;67:362-3.  Back to cited text no. 10
Chalah MA, Ayache SS, Riachi N, Ahdab R. Permanent reversal of essential tremor following a frontal lobe stroke. J Neurol Sci 2015;15;354:133-4.  Back to cited text no. 11
Mailankody P, Netravathi M, Pal PK. Review of tremor in Parkinson's disease and atypical parkinsonian disorders. Neurol India 2017;65:1083-90.  Back to cited text no. 12
[PUBMED]  [Full text]  


  [Figure 1]


Print this article  Email this article
Online since 20th March '04
Published by Wolters Kluwer - Medknow