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| LETTERS TO EDITOR |
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| Year : 2019 | Volume
: 67
| Issue : 4 | Page : 1142 |
Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation
Beuy Joob1, Viroj Wiwanitkit2
1 Medical Center, Sanitation, Medical Academic Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Haikou, China
| Date of Web Publication | 10-Sep-2019 |
Correspondence Address:
Dr. Beuy Joob
Sanitation, Medical Academic Center, Bangkok
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0028-3886.266266
How to cite this article:
Joob B, Wiwanitkit V. Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation. Neurol India 2019;67:1142 |
Sir,
Cyclooxygenase-2 (COX-2) is an important enzyme for the synthesis of prostaglandins bioprocess. COX-2 plays a role in inflammation response. There are many reports regarding the relationship between COX-2 and the pathogenesis of Alzheimer's disease (AD). In a recent meta-analysis study by Luo et al., it was concluded that “C-allele of rs20417 (-765G>C) polymorphism was associated with a reduced risk of AD, which might be a protective factor.”[1] Here, the authors used the basic quantum calculation for determining the molecular weight change in G to C type and found that there was a reduction from 151.13 to 111.1. The molecular weight reduction can imply that more energy is required for the biological process of final enzyme reaction or increased difficulty for COX-2 expression. This is concordant with the finding that increased expression of COX-2 was observed in cases with severe AD.[2] In fact, the phenomenon is the same as the molecular weight change described by quantum calculation study in previous reports on disease-related polymorphisms.[3],[4] Hence, the effect of COX-2 polymorphism on AD susceptibility can be confirmed. Nevertheless, it should be noted that there are other genes polymorphisms that might affect the susceptibility for AD. A good example is phospholipase A2 enzyme gene.[5] Clarifying the combinatorial effect among different gene polymorphisms on the susceptibility of AD is very interesting.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| » References | |  |
| 1. | Luo D, Long Y, Chen GJ. Cyclooxygenase-2 gene polymorphisms and risk of Alzheimer's disease: A meta-analysis. J Neurol Sci 2015;359:100-5.  |
| 2. | Ho L, Purohit D, Haroutunian V, Luterman JD, Willis F, Naslund J, et al. Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch Neurol 2001;58:487-92.s. |
| 3. | Joob B, Wiwanitkit V. HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: Quantum chemical analysis and implication in patients with renal transplantation. J Nephropharmacol 2016;6:19-20. |
| 4. | Joob B, Wiwanitkit V. ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) polymorphism and clopidogrel concentration in acute coronary syndrome: Molecular change can explain the observed therapeutic concentration. Anatol J Cardiol 2016;16:303-4. |
| 5. | Cordeiro Q, Noguti R, Bottino CM, Vallada H. Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease. Arq Neuropsiquiatr 2010;68:189-93. |
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