Atormac
brintellex
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 2217  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed435    
    Printed2    
    Emailed0    
    PDF Downloaded20    
    Comments [Add]    

Recommend this journal

 

 REVIEW ARTICLE
Year : 2020  |  Volume : 68  |  Issue : 5  |  Page : 1003--1007

Statin for Migraine Headache: Is It Worthwhile?


1 Faculty Member of Education Development Center, Psychiatrist, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 International Affairs Department (IAD), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Research Center of Thalassemia and Hemoglobinopathies, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Clinical Pharmacy, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Dr. Fakher Rahim
Research Center of Thalassemia and Hemoglobinopathies, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.299154

Rights and Permissions

Migraine is a severe primary headache disorder that affects about 12% of the population, and it often occurs along with nausea, vomiting, and extreme sensitivity to light and sound. For patients with migraine, beta-blockers, antidepressants, anticonvulsants, are given as the first line of preventive treatment; alternatives include calcium channel blockers. Not only statins prevent the synthesis of cholesterol biosynthesis but also they have a pleiotropic effect such as antiinflammatory effects, antioxidant property, antiproliferative and immunomodulatory effects, the stability of plaque, normalization of sympathetic outflow, and inhibit of platelet aggregation. Here, we should focus on the evidence that works on the effect of the statins on migraine headaches, especially in patients who do not respond to first-line prevention treatments. The hypothesis may show that statins could be effective in the treatment of patients with migraine. Taken together, some epidemiologic, clinical, and experimental evidence suggest that statin may be a novel and promising candidate. For future treatment or prophylaxis of migraine, we hope that the use of this drug as cholesterol and triglycerides(blood lipids) leads to rebate drugs, as well as to reduce migraine headaches episodes agent to enhance the role of this drug in cure or prevent migraine attacks or recurrence, and finally to improve the patient's quality of life.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow