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Table of Contents    
Year : 2020  |  Volume : 68  |  Issue : 5  |  Page : 1242

Role of Decompressive Craniectomy in Traumatic Brain Injury – Response to the Meta-Analysis

Department of Anesthesiology, Government Medical College, Thiruvananthapuram, Kerala, India

Date of Web Publication27-Oct-2020

Correspondence Address:
Dr. Varun Suresh
Department of Anesthesiology, Government Medical College, Thiruvananthapuram - 695 011, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.294560

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How to cite this article:
Suresh V. Role of Decompressive Craniectomy in Traumatic Brain Injury – Response to the Meta-Analysis. Neurol India 2020;68:1242

How to cite this URL:
Suresh V. Role of Decompressive Craniectomy in Traumatic Brain Injury – Response to the Meta-Analysis. Neurol India [serial online] 2020 [cited 2021 Sep 17];68:1242. Available from:


I read with great interest the meta-analysis on the Role of Decompressive Craniectomy in Traumatic Brain Injury (TBI) by Garg et al.[1] I appreciate the authors for bringing into consideration the evidence gained from the RESCUE ICP trail[2] which was published after the release of the latest Brain Trauma Foundation guidelines in 2016.[3] However, I would like to bring to notice a few more limitations which must be considered while addressing this topic.

A total of 82 patients with mass lesions in CT head were randomized to medical and surgical group (45 patients [24.2%] to medical and 37 patients [18.7%] to craniectomy, respectively) in the RESCUE ICP trial. Although all cases included in the DECRA trial[4] were of diffuse lesions after TBI, it needs to be further reiterated that the majority among 82 patients with mass lesions in CT from the RESCUE ICP trial were those cases who underwent evacuation of mass lesions initially, with the bone flap being replaced after the procedure.

I affirm with the fact stated by the authors that there is significant heterogeneity in the included studies in this meta-analysis. There are innumerable ethical considerations in randomizing patients with mass lesions after TBI into medical versus surgical management. Furthermore, a cross-sectional analysis of patients into medical and craniectomy groups across diffuse and focal lesions in CT head, from the four major trials considered in this meta-analysis, would have been an added advantage for the readers to understand.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Garg K, Singh PM, Singla R, Aggarwal A, Borle A, Singh M, et al. Role of decompressive craniectomy in traumatic brain injury – A meta-analysis of randomized controlled trials. Neurol India 2019;67:1225-32.  Back to cited text no. 1
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Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, et al. Trial of decompressive craniectomy for traumatic intracranial hypertension. NEngl J Med 2016;375:1119-30.  Back to cited text no. 2
Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24(Suppl. 1):S1-106.  Back to cited text no. 3
Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D'Urso P, et al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 2011;364:1493-502.  Back to cited text no. 4


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