Atormac
brintellex
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 540  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (514 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References

 Article Access Statistics
    Viewed582    
    Printed8    
    Emailed0    
    PDF Downloaded21    
    Comments [Add]    

Recommend this journal

 


 
Table of Contents    
SPECIAL NI FEATURE: PEARLS FROM PAST
Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1281-1284

Expert Commentary on “The Brain and Meninges in Tuberculosis Meningitis - Gross Pathology in 100 Cases and Pathogenesis” by Darab K Dastur, VS Lalitha, PM Udani, and Usha Parekh


National Brain Research Centre, Manesar, Gurugram, Haryana, India

Date of Web Publication19-Dec-2020

Correspondence Address:
Prof. Prakash Narain Tandon
National Brain Research Centre, Nainwal Mode, Manesar, Gurugram - 122 051, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.304083

Rights and Permissions



How to cite this article:
Tandon PN. Expert Commentary on “The Brain and Meninges in Tuberculosis Meningitis - Gross Pathology in 100 Cases and Pathogenesis” by Darab K Dastur, VS Lalitha, PM Udani, and Usha Parekh. Neurol India 2020;68:1281-4

How to cite this URL:
Tandon PN. Expert Commentary on “The Brain and Meninges in Tuberculosis Meningitis - Gross Pathology in 100 Cases and Pathogenesis” by Darab K Dastur, VS Lalitha, PM Udani, and Usha Parekh. Neurol India [serial online] 2020 [cited 2021 Jan 21];68:1281-4. Available from: https://www.neurologyindia.com/text.asp?2020/68/6/1281/304083


I deem it a privilege to have been asked by Prof. P. Sarat Chandra, Editor, to write a Commentary on the paper mentioned above by Prof. Dastur et al., published half a century ago. Prof. Dastur was not only a personal friend, but we also had a common interest in this subject. We ended up jointly co-editing a monograph “Tuberculosis of the Nervous System” in 1973.[1]

Before I comment on this paper, let me say a few words about the author, who was one of the pioneers of neuropathology in the country who set standards for high-quality research, notwithstanding limited facilities. He was a meticulous, deeply committed, untiring scientist with an obsession for details and clinicopathological correlation. Besides neuro-tuberculosis and neuro-oncology, he contributed to diverse neuropathologic conditions, which included experimental studies on poliomyelitis, pathology of leprosy, Japanese encephalitis, Kyasanur Forest Disease, nutritional neuropathology, and lathyrism, among others.[2]

Coming to the subject of the paper under consideration, having extensively reviewed the subject personally and followed it throughout my professional life, I can state without fear of being contradicted that Prof. Dastur et al.'s description of the “Gross Pathology” of brain and meninges in tuberculous meningitis is undoubtedly the most detailed account on the subject reflecting his characteristic, scientific traits mentioned above.[3]

Beginning with a brief historical introduction on the subject, particularly the earliest Indian contributions of Morehead[4] (1849) from Bombay (now Mumbai), he has meticulously described the gross pathology of 100 brains of the patients (78 children and 22 adults) who died of tuberculosis meningitis. While describing the pathological findings, attention has been paid to clinical correlations [Table 2]. The nature and extent of the meningeal exudate are provided in meticulous details, supported by ten figures of autopsy specimens. “It is highly recommended for the readers interested in the history of tuberculous meningitis to refer to the following articles by the authors such as Pandya[5] and Tandon.[6],[7],[8]

The co-existing parenchymal pathology consisting of border-zone encephalitis, diffuse edema, ventriculitis, infarction, and tuberculomas has been precisely recorded. These lesions have been correlated with duration of the disease [Figure 12], among those who were treated or untreated [Figure 11]. A detailed account has been provided of the involvement of the arteries of the circle of Wills and consequent infarction of the brain and occasional hemorrhagic lesions.[3] This has been further elaborated in other publications in the same year (Dastur and Lalitha, 1973).[9],[10]

It is interesting to note that the unique entity, “Tuberculosis encephalopathy with and without meningitis” a subject of several papers by Dastur and Udani, published before this paper, does not find any reference to it in this detailed study of 100 brains.[11],[12],[13] In this paper, there is only a passing reference to it, “Another interesting but prognostically serious mechanism of brain damage accompanying even mild tuberculous meningitis and leading to rapid death, is diffuse cerebral edema.” In these papers, not only is the entity called “Tuberculous Encephalopathy,” but also a detailed account of its macro and microscopic features is provided. They attribute it as some type of allergic response.[11],[12],[13]

In the same issue of Neurology India, in our paper on “Experimental Tuberculosis of the Nervous System,” we had described similar pathology observed in monkeys, a model of the tuberculosis of the central nervous system. It stated, “hypersensitized animals showed a tendency to exaltate the reaction resulting in a much degree of edema and necrosis,” as illustrated in [Figure 8] of this paper.[14],[15] When brought to his notice, Dastur agreed to the similarity and pathogenetic basis of the two lesions. This was further elaborated by Dastur et al.[9],[15],[16] The possible role of proteins liberated by dead tubercle bacilli in the pathogenesis of such lesions was referred by Ridley[17] and Chandramukhi and Shankar.[18]

Before discussing this paper further, let me mention some of the other papers by him on the subject of neuro-tuberculosis. Dastur and Wadia described the clinical and pathological features of spinal meningitis and radiculopathy.[19],[20] Dastur and Lalitha (1970) published a detailed account of “Many facts of neuropathology of neuro-tuberculosis: an epitome in neuropathology” in progress in neuropathology edited by Zimmerman.[9] Udani et al. (1971) elaborated their extensive experience on “Neurological and related syndromes of CNS tuberculosis: Clinical features and pathogenesis.”[21]

Dastur and Dave (1977) described “Ultrastructural basis of vasculopathy in and around brain tuberculoma – The possible significance of altered basement membrane.”[22] Dastur and Dave provided “Further observations on the fine structure of blood vessels in neuro-tuberculosis” in Advances in Neurology edited by Cervos Navarro.[23]

In addition, Dastur et al. published a series of papers on the other aspects of CNS tuberculosis, which dealt mostly with brain tuberculomas.[24],[25],[26],[27],[28] Reviewing this paper also brings nostalgic memories of our work and those of other colleagues on the subject of neuro-tuberculosis, some of which elaborated Dastur's observations while others provided new knowledge. I take the liberty to refer to these for the sake of our younger colleagues and in the interest of our history. The subject of neuro-tuberculosis aroused widespread interest in the country in the 1960s and 1970s, first owing to the frequency of the disease and second because the interest in the subject abroad had waned.

In the interval between the publication by Moorhead (1849) and the initiation of the first Neurosurgical Service in India by Dr. Chandy, I could find two interesting papers on the subject of neuro-tuberculosis. The first one was by De, a renowned microbiologist, who in 1949 published a paper in the British Medical Journal “Streptomycin in development of hydrocephalus in tuberculous meningitis.”[29] This was soon after the availability of streptomycin in the country. In 1951, Reddy, a pathologist, published the first report on autopsy proved four tuberculomas among 38 cases of intracranial tumors.[30] Soon after Chandy and Isaiah (1952) reported on 8 cases of tuberculomas of the brain,[31] while Ramammurthi (1956) reported 35 cases.[32] These were followed by a number of reports on intracranial tuberculomas from different centers. Bagchi from Calcutta,[33] Ramamurthi and Varadarajan,[34] Ramamurthi and Natrajan,[35] Ramamurthi Madras.[36] Dastur and Anil Desai,[37],[38] Dastur and Shah,[24] Sinh et al.[26] from Bombay, Mathai,[39] and Mathai and Chandy[40] from Vellore provided a detailed account of these lesions.

However, there were a large number of publications on the different facets of neuro-tuberculosis in the 1960s and 1970s. The following account is mostly restricted to this period. More recent papers on the subject are not included. Thus, Khatua,[41] Ginde,[42] Ghosh,[43] Mathai and Chandy,[40] Deshpande et al.,[44] Bharucha et al.,[45] Tandon and Pathak,[46] and Tandon and Tandon[47] dealt with in detail various aspects of tuberculous meningitis. Ginde and Banker,[48] Singh et al.,[49] Bawa and Wahi,[50] Rao and Subrahmanyam,[51] Tandon and Mishra,[52] and Kak et al.[53] described primary and secondary spinal meningitis/arachnoiditis.

Raised intracranial pressure and postmeningitic hydrocephalus were the subjects of a number of publications dealing with its pathogenesis, diagnosis, and therapy. Dastur et al.,[54] Bhagwati and Singhal,[55],[56] Singhal et al.,[57] Tandon et al. (1975),[58],[59] Bhargava et al.,[60] and Mitra et al.[61]

Arteritis, an important feature of tuberculosis meningitis, described in details by Dastur et al. was further investigated by Wadia and Singhal,[62] Mathew et al.,[63] Misra PK et al., (1973),[64] Dalal et al.,[65] and Dastur and Dave.[22],[23]

Over the years, besides the references included here, we published a chapter in national and international textbooks comprehensively dealing with the subject, Tandon and Pande.[66] This has been summarized in a monograph “My Tryst with Biomedical Research” and a recent review in National Medical Journal.[67],[68] Obviously, there have been many more contributions by other colleagues in India in recent years than listed here. Comments here are primarily directed to the features highlighted in the paper under review. It is worth mentioning that Indian contributors in the field were widely recognized. In a book on “Infections of the Nervous System,” Kennedy and Jhonson published by Butterworth in 1987 Kocen writing on the Tuberculosis of the Nervous System stated that “In more recent years, the major contributions on both pathology and the varied clinical manifestations of the brain and spinal cord have come from workers in India, in particular Dastur, Tandon, and Wadia.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Annexure: [Additional file 1]



 
  References Top

1.
Kapila CC, Dastur DK, Singh B, Tandon PN. Tuberculosis of the Nervous System: Proceedings of a Symposium. New Delhi: Indian Academy of Sciences; 1973.  Back to cited text no. 1
    
2.
Tandon PN. Founders of Indian Neurosciences: Professor Autar Singh Paintal and Professor Darab Kersasp Dastur. Neurol India 2018;66:301-3.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Dastur DK, Lalitha VS, Udani PM, Parekh U. The brain and meninges in tuberculous meningitis-Gross pathology in 100 cases and pathogenesis. Neurol India 1970;18:86-100.  Back to cited text no. 3
    
4.
Morehead V. Article V in Transactions of the Medical and Physical Society. Bombay: The American Mission Press; 1848. p. 112-54.  Back to cited text no. 4
    
5.
Pandya SK. Classic descriptions of neurological disorders by Charles Morhead. Neurol India 1970;18:50-65.  Back to cited text no. 5
    
6.
Tandon PN. Tuberculous meningitis (Cranial and Spinal) In: Vinken PJ, Bruyn GW, editors. Handbook of Clinical Neurology. Vol. 33. North-Holland: Amsterdam; 1978. p. 195-262.  Back to cited text no. 6
    
7.
Tandon PN. Nervous system tuberculomas and their treatment. Neurol Infn Epid 1996;1:109-17.  Back to cited text no. 7
    
8.
Ramamurthi B, Tandon PN. Tuberculosis of the nervous system. In: Textbook of Neurosurgery. 2nd ed. New Delhi: B.I. Churchill Livingstone Pvt. Ltd.; 1996. p. 475-88.  Back to cited text no. 8
    
9.
Dastur DK, Lalitha VS. The many facets of neurotuberculosis: An epitome of neuropathology. In: Zimmerman HM, Grune, Stratton, editors. Progress in Neuropathology. New York: 1973. p. 351-408.  Back to cited text no. 9
    
10.
Lalitha VS, Dastur DK. Histopathology of blood vessels in neuro-tuberculosis. In: Kapila CC, Dastur DK, Singh B, Tandon PN, editors. Tuberculosis of the Nervous System. New Delhi: Indian Academy of Medical Sciences; 1973.  Back to cited text no. 10
    
11.
Dastur DK, Udani PM. Tuberculous encephalopathy with and without meningitis. Clinical features and pathological correlation. J Neurol Sci 1970;10:543-61.  Back to cited text no. 11
    
12.
Dastur DK, Udani PM. Pathology and Pathogenesis of Tuberculous Encephalopathy. Excerpta Medica (International Congress Series 100); 1965. p. 1006-10.  Back to cited text no. 12
    
13.
Dastur DK, Udani PM. The pathology and pathogenesis of tuberculous encephalopathy. Acta Neuropathol 1966;6:311-26.  Back to cited text no. 13
    
14.
Tandon PN, Singh B, Mohapatra LN, Kumar M, Das BS. Experimental tuberculosis of the nervous system. Neurol India 1970;28:81-5.  Back to cited text no. 14
    
15.
Tandon PN, Singh B, Mohapatra LN, Kumar M. Effect of “immunization” and “sensitization” of tuberculous lesions of the central nervous system in monkeys. In: Kapila CC, Dastur DK, Singh B, Tandon PN, editors. Tuberculosis of the Nervous System. New Delhi: Indian Academy of Medical Sciences; 1973. p. 213-21.  Back to cited text no. 15
    
16.
Dastur DK. The pathology and pathogenesis of tuberculous encephalopathy and myeloradiculopathy: A comparison with allergic encephalomyelitis. Child's Nerv Syst 1986;2:13-9.  Back to cited text no. 16
    
17.
Ridley DS. The histopathological spectra of mycobacteria. In: Ratledge C, Standord J, editors. The Biology of Mycobacteria. Academic Press. 1983. p. 128.  Back to cited text no. 17
    
18.
Chandramukhi A, Shankar SK. Intracranial tuberculomas-Are they really disappearing? Neurol India 1988;36:395-6.  Back to cited text no. 18
    
19.
Wadia NH, Dastur DK. Spinal meningitides and readiculomyelopathy. Part I: Clinical and radiological features. J Neurol Sci 1969;8:239-60.  Back to cited text no. 19
    
20.
Dastur DK, Wadia NH. Spinal meningitides and readiculomyelopathy. Part II: Pathology and pathogenesis. J Neurol Sci 1969;8:261-97.  Back to cited text no. 20
    
21.
Udani PM, Parekh UC, Dastur DK. Neurological and related syndromes in CNS tuberculosis. Clinical features and pathogenesis. J Neurol Sci 1971;14:341-57.  Back to cited text no. 21
    
22.
Dastur DK, Dave UP. Ultrastructural basis of the vasculopathy in and around brain tuberculomas. Possible significance of altered basement membrane. Am J Pathol 1977;89:35-50.  Back to cited text no. 22
    
23.
Dastur DK, Dave UP. Further observations on the fine structure of blood vessels in neurotuberculosis. Possible significance of vasculitis with proliferated basement membrane. In: Cervos Navarro J, et al, editors. Advances in Neurology. Raven Press; 1978.  Back to cited text no. 23
    
24.
Dastur HM, Shah MD. Intramedullary tuberculoma of the spinal cord. Indian Pediatr 1968;5:468-71.  Back to cited text no. 24
    
25.
Dastur DK, Lalitha VS, Prabhakar V. Analysis of 1000 intracranial space-occupying lesions. Part I. Age, Sex, Pattern and the tuberculomas. J Neurol Sci 1968;6:575-92.  Back to cited text no. 25
    
26.
Sinh G, Pandya SK, Dastur DK. Pathogenesis of unusual intracranial tuberculomas and tuberculous space-occupying lesions. J Neurosurg 1968;29:149-59.  Back to cited text no. 26
    
27.
Dastur HM. A tuberculoma review with personal experience. Part I: Brain. Neurol India 1972;20:111-26.  Back to cited text no. 27
    
28.
Lalitha VS, Dastur DK. Tuberculosis of the central nervous system. Part II: Brain tuberculomas vis-à-vis intracranial space-occupying lesions. Neurol India 1980;28:202-6.  Back to cited text no. 28
    
29.
De SN. Streptomycin in development of hydrocephalus in tuberculous meningitis. Brit Med J 1949;2:214.  Back to cited text no. 29
    
30.
Reddy DJ. Tuberculoma of brain. Indian J Surg 1951;13:138-43.  Back to cited text no. 30
    
31.
Chandy J, Isaiah P. Tubercloma of brain. J Ind Med Assoc 1952;21:239.  Back to cited text no. 31
    
32.
Ramammurthi B. Experiences with tuberculomas of the brain. Indian J Surg 1956;18:452-5.  Back to cited text no. 32
    
33.
Bagchi A. The intracranial tuberculomas. J Ind Med Assoc 1961;37:429-33.  Back to cited text no. 33
    
34.
Ramamurthi B, Varadarajan MG. Diagnosis of tuberculomas of the brain. Clinical and radiological correlation. J Neurosurg 1961;18:1-7.  Back to cited text no. 34
    
35.
Ramamurthi B, Natrajan M. Treatment of the tuberculomas of the brain in children. Indian J. Child Health 1960;9:193-7.  Back to cited text no. 35
    
36.
Ramamurthi B. Tubercloma of brain. In: Kapila CC, Dastur DK, Singh B, Tandon PN, editors. Tuberculosis of the Nervous System. New Delhi: Indian Academy of Medical Sciences; 1973. p. 85-9.  Back to cited text no. 36
    
37.
Dastur HM, Desai AD. A comparative study of brain tuberculomas and gliomas based upon 107 case records of each. Brain 1965;88:375-96.  Back to cited text no. 37
    
38.
Dastur HM. A tuberculoma review with personal experience. Part II: Spinal cord and its Coverings. Neurol India 1972;20:127-31.  Back to cited text no. 38
    
39.
Mathai KV. Diagnosis of the intracranial tuberculoma. Neurol India. 1979;27:63.  Back to cited text no. 39
    
40.
Mathai KV, Chandy J. Tuberculous infections of the nervous system. Clin Neurosurg 1966;14:145-77.  Back to cited text no. 40
    
41.
Khatua SP. Tuberculous meningitis in children. Analysis of 231 cases. J Indian Med Assoc 1961;37:332.  Back to cited text no. 41
    
42.
Ginde RG. Visual failure in tuberculous meningitis. In: Paper Presented at the First Asian and Australasian Conference of Neurology and Neurosurgery. Tokyo: 1962.  Back to cited text no. 42
    
43.
Ghosh S. Tuberculous meningitis in children. Pathological observation. J Indian Med Assoc 1963;41:538.  Back to cited text no. 43
    
44.
Deshpande DH, Bharucha EP, Mondkar VP. Tuberculous meningitis in adults (a clinic-pathological study of 18 cases). Neurol India 1969;17:28-34.  Back to cited text no. 44
    
45.
Bharucha PE, Iyer CG, Bharucha EP, Deshpande DH. Tuberculous meningitis in children (a clinic-pathological evaluation of 24 cases). Indian Paed 1969;6:282-90.  Back to cited text no. 45
    
46.
Tandon PN, Pathak SN. Tuberculosis of the central nervous system. In: Spillane JD, editor. Tropical Neurology. London: Oxford University Press; 1973. p. 37-62.  Back to cited text no. 46
    
47.
Tandon PN, Tandon HD. A continuing challenge of tuberculous meningitis. J AIIMS 1975;1:99-112.  Back to cited text no. 47
    
48.
Ginde RG, Banker DD. Paraplegia due to tubercular granuloma of spine resembling intraspinal tumour. Neurol India 1954;2:29-32.  Back to cited text no. 48
    
49.
Singh A, Jolly SS, Goyal AC. Spinal tuberculous meningitis. Neurol India 1959;7:7-8.  Back to cited text no. 49
    
50.
Bawa YS, Wahi PL. Spinal tuberculous meningitis. J Ind Med Assoc 1961;37:449-52.  Back to cited text no. 50
    
51.
Rao BD., Subrahmanyam MV. Spinal Complications of tuberculous meningitis. Neurol India 1962;10:62.  Back to cited text no. 51
    
52.
Tandon PN, Mishra RN, Singh B. Post-meningitic Spinal ar achnoiditis. Bull AIIMS 1968;20:104-5.  Back to cited text no. 52
    
53.
Kak VK, Pani KC, Chopra JS. Epidural spinal tuberculoma presenting as 'spinal tumour syndrome'. Tubercle 1972;53:139-42.  Back to cited text no. 53
    
54.
Dastur HM, Pandya SK, Rao MY. Aetiology of hydrocephalus in tuberculous meningitis. Neurol India 1972;20 Suppl 1:73-9.  Back to cited text no. 54
    
55.
Bhagwati SN, Singhal BS. Raised intracranial pressure as a mode of presentation in tuberculous meningitis. Neurol India 1970;18:116-9.  Back to cited text no. 55
    
56.
Bhagwati SN. Ventriculo-atrial shunt in tuberculous meningitis with hydrocephalus. J Neurosurg 1971;35:309.  Back to cited text no. 56
    
57.
Singhal BS, Bhagwati SN, Syed AH, Laud GW. Raised intracranial pressure in tuberculous meningitis. Neurol India 1975;23:32-9.  Back to cited text no. 57
    
58.
Tandon PN, Rao MA, Pathak SN, Dar J. RIHSA cisternography in the management of tuberculous meningitis. In: Kapila CC, Dastur DK, Singh B, Tandon PN, editors. Tuberculosis of the Nervous System. New Delhi: Indian Academy of Medical Sciences; 1973.  Back to cited text no. 58
    
59.
Tandon PN, Rao MA, Banerjee AK, et al. Radio-isotope scanning of the cerebrospinal fluid pathways in tuberculous meningitis. J Neurol Sci 1970;25:401-13.  Back to cited text no. 59
    
60.
Bhargava S, Gupta AK, Tandon PN. Tuberculous meningitis. A CT study. Brit J Radiol 1982;55:189-96.  Back to cited text no. 60
    
61.
Mitra DK, George J, Singh DC. Hydrocephalus caused by tuberculous meningitis: Clinical picture, CT findings and result of shunt surgery. Z Kinderchir 1983;38:76-9.  Back to cited text no. 61
    
62.
Wadia NH, Singhal BS. Cerebral arteriography in tuberculous meningitis (a study of 33 cases). Neurol India 1967;15:127-32.  Back to cited text no. 62
    
63.
Mathew NT, Abraham J, Chandy J. Cerebral angiography features in tuberculous meningitis. Neurol India (Minneap) 1970;20:1015.  Back to cited text no. 63
    
64.
Misra PK, Agarwal MP, Sharma NL, Chhabra DK, Dave VS. Cerebral angiography in tuberculous meningitis. Indian Pediatr 1973;10:613-8.  Back to cited text no. 64
    
65.
Dalal PM, Rao KS, Khandeparkar NM, et al. Some observations on the involvement of blood vessels in tuberculous meningitis. In: Kapila CC, Dastur DK, Singh B, Tandon PN, editors. Tuberculosis of the Nervous System. New Delhi: Indian Academy of Medical Sciences; 1973. p. 269-75.  Back to cited text no. 65
    
66.
Tandon PN, Pande A. (a) Tuberculosis of the central nervous system, (b) Tuberculous meningitis. In: Tandon PN, Ramamurthi R. Textbook of Neurosurgery. 3rd ed. New Delhi: Jaypee Brothers Medical Publishers Pvt. Ltd.; 2012. p. (a) 725-41, (b) 741-52.  Back to cited text no. 66
    
67.
Tandon PN. Neurotuberculosis. In: My Tryst with Biomedical Research. A Monograph. India: The National Academy of Sciences; 2015. p. 27-31.  Back to cited text no. 67
    
68.
Tandon PN. Management of tuberculosis of the central nervous system: Our experience. Natl Med J India 2018;31:151-5.  Back to cited text no. 68
[PUBMED]  [Full text]  




 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow