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Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1295--1300

Liquid Biopsy in Gliomas- A Review

Sr Consultant Neurosurgeon Department of Neurosurgery, Apollo Hospitals; Founder Director- Exsegen Research, Hyderabad, Telangana, India

Correspondence Address:
Dr. Amitava Ray
Third Floor; Nirvanaz, 8-2-293/82/A/240, Road 36; Jubilee Hills, Hyderabad – 500033, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.304105

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Background: Are we witnessing the end of the biopsy as we know it? Is this the start of a revolution in cancer diagnostics and treatment where analysis of somatic mutations present in the blood, CSF, or urine followed by targeted therapy replaces the traditional surgery followed by chemo-radiation? Since 2016, molecular markers are an integral part of the 'glioma' treatment decision-making process- diagnostic, prognostic, and therapeutic. A lot of these somatic mutations that identify and prognosticate tumors are also detected in the adjoining bio-fluids in serum or CSF- the sampling of which is known as liquid biopsy. Objective: The objective of this study is to review the advancement of scientific techniques that now allows the investigation of these bio-fluids, to diagnose, prognosticate and treat gliomas. Material and Methods: This review article is an exhaustive review of the literature that summarises the role of the three main liquid biopsy modalities- Circulating Tumor Cells, Cell-free Tumor DNA and Exosomes in the detection of known diagnostic and prognostic markers in gliomas. Results: The current review highlights the strengths and weaknesses of the diffrerent modalities in use, and their potential use in the clinical setting. Conclusion: Liquid biopsies hold tremendous potential in the diagnosis and management of gliomas in the future.


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Online since 20th March '04
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