Atormac
brintellex
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 3498  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (619 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References
   Article Figures

 Article Access Statistics
    Viewed610    
    Printed4    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal

 


 
Table of Contents    
NEUROIMAGE
Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1508

Neurocutaneous Melanosis: Cutaneous and Neuroimaging Findings


Department of Neurology, SCTIMST, Trivandrum, India

Date of Web Publication19-Dec-2020

Correspondence Address:
Dr. Ashalatha Radhakrishnan
Professor of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care (RMNC), In-Charge, Comprehensive Center For Sleep Disorders (CCSD), Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), (An Institute of National Importance Under Department of Science & Technology, Government of India) Trivandrum - 695 011, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.304124

Rights and Permissions



How to cite this article:
Ramachandran H, Radhakrishnan A, Radhakrishnan SE. Neurocutaneous Melanosis: Cutaneous and Neuroimaging Findings. Neurol India 2020;68:1508

How to cite this URL:
Ramachandran H, Radhakrishnan A, Radhakrishnan SE. Neurocutaneous Melanosis: Cutaneous and Neuroimaging Findings. Neurol India [serial online] 2020 [cited 2021 Jan 24];68:1508. Available from: https://www.neurologyindia.com/text.asp?2020/68/6/1508/304124




A 2-year-old boy presented with frequent complex partial seizures since two months of age and global developmental delay. He had classical cutaneous lesions of NCM [Figure 1]. NCM is a nonfamilial neurocutaneous syndrome of poor neurological prognosis. There are large cutaneous melanocytic naevi and CNS melanin deposits due to defective migration of melanoblasts from neural crest with frequently seen bathing suit pattern skin lesions.[1] MRI shows bilateral amygdala T1 hyperintensities due to paramagnetic properties of melanin which is commonly described with NCM.[1],[2] In this context with the typical cutaneous and imaging findings, there are no other differential diagnosis.
Figure 1: (a, b) Multiple large cutaneous naevi with satellite lesions (black arrows) in a cape shaped or bathing suit distribution. (c) Multiple satellite lesions with hypertrichosis. (d): Bilaterally symmetric T1 hyperintense lesions in amygdala (white arrows) in axial MRI brain

Click here to view


Acknowledgment

The authors thank Mr. Lijikumar G, Scientific officer, Medical Illustration who helped in obtaining high-quality images.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Scattolin MAA, Lin J, Peruchi MM, Rocha AJ, Masruha MR, Vilanova LCP. Neurocutaneous melanosis: Follow-up and literature review. J Neuroradiol 2011;38:313-8.  Back to cited text no. 1
    
2.
Ramaswamy V, Delaney H, Haque S, Marghoob A, Khakoo Y. Spectrum of central nervous system abnormalities in neurocutaneous melanocytosis: CNS abnormalities in neurocutaneous melanocytosis. Dev Med Child Neurol 2012;54:563-8.  Back to cited text no. 2
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow