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Year : 2021  |  Volume : 69  |  Issue : 2  |  Page : 457--460

Interleaved Stimulation for Freezing of Gait in Advanced Parkinson's Disease

1 Department of Neurology, Saifee Hospital, Mumbai, Maharashtra, India
2 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
3 Comprehensive Care Center for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India

Correspondence Address:
Asha Kishore
Senior Consultant and Movement Disorder Specialist Center of Excellence in Neurosciences Aster Medicity, Kochi - 682027, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.314570

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Background: Freezing of gait (FOG) is a disabling and refractory symptom of advanced Parkinson's disease (PD). Interleaved stimulation (ILS) is a novel paradigm which may benefit axial symptoms of PD. Objectives: To assess the effect of ILS on FOG in patients unresponsive to conventional subthalamic nucleus (STN) stimulation. Methods: 19 PD patients receiving subthalamic stimulation and experiencing FOG at both conventional (130–150Hz) and low frequency (60Hz) stimulation were given ILS.The primary outcome measure was the UPDRS part III gait score (item 29) at 3 months after ILS. A subset of patients was tested with the stand–walk–sit (SWS) test, 30 min after ILS. Results: The mean UPDRS part III gait score (baseline: 1.8 ± 0.6) improved at 30 min (1.1 ± 0.8, P = 0.017) and remained improved at 3 months (1.2 ± 0.8, P = 0.048). FOG episodes reduced during SWS test (P = 0.041). Conclusions: ILS of STN through two adjacent contacts provided significant short-term beneficial effects on FOG.


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