| BRIEF REPORT
|Year : 2021 | Volume
| Issue : 2 | Page : 461--465
Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population
Tania Saha1, Somrita Roy1, Rajashree Chakraborty1, Arindam Biswas2, Shyamal K Das3, Kunal Ray4, Jharna Ray2, Mainak Sengupta1
1 Department of Genetics, University of Calcutta, Kolkata, West Bengal, India
2 S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, West Bengal, India
3 Movement Disorders Clinic, Bangur Institute of Neurosciences, Kolkata, West Bengal, India
4 School of Biological Sciences, RKMVERI, Narendrapur, West Bengal, India
Background: Parkinson's disease (PD) is a multifaceted illness affecting ~ 0.3% of the world population. The genetic complexity of PD has not been, fully elucidated. Several studies suggest that mitochondrial DNA variants are associated with PD.
Objective: Here, we have explored the possibility of genetic association between mitochondrial haplogroups as well as three independent SNPs with PD in a representative east Indian population.
Methods and Material: The Asian mtDNA haplogroups: M, N, R, B, D, M7, and 3 other SNPs: 4336 T/C, 9055 G/A, 13708 G/A were genotyped in 100 sporadic PD patients and 100 matched controls via conventional PCR-RFLP-sequencing approach.
Results: The distribution of mtDNA haplogroups, as well as 3 single polymorphisms, did not show any significant differences (P > 0.05) between patients and controls.
Conclusion: This is the first of its kind of study from India that suggests no association of selected mitochondrial DNA variations with PD.
Dr. Mainak Sengupta
35, Ballygunge Circular Road, Kolkata - 700 019
Source of Support: None, Conflict of Interest: None
[FULL TEXT] [PDF]*