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Table of Contents    
Year : 2021  |  Volume : 69  |  Issue : 3  |  Page : 774

Multiple Giant Skull Osteomas Associated with Gardner's Syndrome

Department of Neurosurgery, Achantha Lakshmipathy Neurosurgical Centre, Voluntary Health Services Hospital, Taramani, Chennai, Tamil Nadu, India

Date of Submission06-Mar-2020
Date of Decision30-Apr-2020
Date of Acceptance09-Jul-2020
Date of Web Publication24-Jun-2021

Correspondence Address:
Dr. Manuel Adarsh
Post Graduate in Neurosurgery, Achantha Lakshmipathy Neurosurgical Centre, Voluntary Health Services, TTTI Post, Taramani, Chennai - 600 113, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.319210

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How to cite this article:
Adarsh M, Chakravarthy V. Multiple Giant Skull Osteomas Associated with Gardner's Syndrome. Neurol India 2021;69:774

How to cite this URL:
Adarsh M, Chakravarthy V. Multiple Giant Skull Osteomas Associated with Gardner's Syndrome. Neurol India [serial online] 2021 [cited 2021 Jul 25];69:774. Available from:

An otherwise healthy 27-year-old gentleman presented with multiple giant slow-growing painless skull tumors. He had no complaints other than occasional heaviness of head. He did not give any history of hearing loss or visual disturbances. On examination tumors were stony hard in consistency and fixed to the calvarium. CT skull was performed, and it showed giant osteomas along the left frontal and bilateral temporo-parieto-occipital regions [Figure 1]. Patient did not have any other systemic symptoms. But on evaluation, he was found to have multiple intestinal polyps, and later Gardner's syndrome (GS) was confirmed.
Figure 1: CT head bone window axial section shows (a-c) bilateral temporo-parieto-occipital exophytic bony tumors suggestive of multiple osteoma, (d) left frontal osteoma, note the thickening of parietal bone

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GS is an autosomal dominant disease with a classical triad of numerous colonic polyps, osteomas, cutaneous, and subcutaneous soft tissue tumors.[1] The syndrome was named after Eldon J. Gardner, a geneticist who first described it in 1951.[2] Osteomas in GS are commonly found in the skull, jaws, and the paranasal sinuses. Osteomas almost always presents early than the gastrointestinal complaints. Hence, the early identification of the syndrome in such patients is very important in preventing the progression of benign intestinal polyps into colorectal cancers.[3] Small lesions are kept under observation. Surgical resection is usually considered for cosmetic correction or when the patient presents with pain or other associated symptoms due to compression of the nearby structures by the tumor.[4]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initial s will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Gardner EJ, Richards RC. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 1953;5:139-47.  Back to cited text no. 1
Gardner EJ. A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. Am J Hum Genet 1951;3:167-76.  Back to cited text no. 2
Katou F, Motegi K, Baba S. Mandibular lesions in patients with adenomatosis coli. J Craniomaxillofac Surg 1989;17:354-8.  Back to cited text no. 3
Quesnel AM, Lee DJ. Extensive osteomas of the temporal-parietal-occipital skull. Otol Neurotol 2011;32:e3.  Back to cited text no. 4


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