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Table of Contents    
Year : 2021  |  Volume : 69  |  Issue : 5  |  Page : 1489

Half Wine Glass Appearance in Early Primary Lateral Sclerosis

1 Department of Neurology, Government Medical College, Kottayam, Kerala, India
2 Department of Radiology, Government Medical College, Kottayam, Kerala, India

Date of Submission25-Nov-2019
Date of Decision27-Nov-2019
Date of Acceptance11-Jul-2020
Date of Web Publication30-Oct-2021

Correspondence Address:
Jidhin Raj
Department of Neurology, Government Medical College, Kottayam - 686 008, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.329618

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How to cite this article:
Raj J, George J, Harris A A, Suresh N, Gourishankar. Half Wine Glass Appearance in Early Primary Lateral Sclerosis. Neurol India 2021;69:1489

How to cite this URL:
Raj J, George J, Harris A A, Suresh N, Gourishankar. Half Wine Glass Appearance in Early Primary Lateral Sclerosis. Neurol India [serial online] 2021 [cited 2021 Dec 4];69:1489. Available from:

A 42-year-old gentleman presented with progressive loss of dexterity and pyramidal weakness of right upper limb for three months duration. There was no cognitive decline, tongue/limb muscle atrophy, fasciculation or sensory loss. Our patient fulfilled the criteria for primary lateral sclerosis[1] except the duration criteria of three years.

Wine glass appearance[2] has been previously described in primary lateral sclerosis with white matter confluent symmetrical hyperintensities of both corticospinal tracts in the coronal section. The hyperintensities of the corticospinal tract of a single side may be considered as an early sign of primary lateral sclerosis [Figure 1].
Figure 1: MRI Brain T2 FLAIR coronal section shows left corticospinal tract hyperintensity. Right corticospinal tract appears normal

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC. Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 1992;115:495-520.  Back to cited text no. 1
Kuruvilla A, Joseph S. 'Wine Glass' appearance: A unique MRI observation in a case of primary lateral sclerosis. Neurol India 2002;50:306-9.  Back to cited text no. 2
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