|Year : 2021 | Volume
| Issue : 6 | Page : 1624
The midline cerebellar lesion in experimental Wernicke disease
Robert Laureno1, Guillaume Lamotte2
1 Medstar Washington Hospital Center, Department of Neurology, 106 Irving St NW; Medstar Georgetown University Hospital, Department of Neurology, 3800 Reservoir Road, Washington, DC, USA
2 Medstar Georgetown University Hospital, Department of Neurology, 3800 Reservoir Road, Washington, DC, USA
|Date of Web Publication||23-Dec-2021|
Dr. Guillaume Lamotte
Medstar Georgetown University Hospital, Department of Neurology, 3800 Reservoir Road, Washington, DC
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Laureno R, Lamotte G. The midline cerebellar lesion in experimental Wernicke disease. Neurol India 2021;69:1624
Pictured are slices of the brainstem (A) and cerebellum (B) from a dog with experimental Wernicke disease [Figure 1]. This image is notable because it demonstrates that a midline cerebellar (vermian) lesion can occur in Wernicke disease. There has been a debate on whether the midline cerebellar disease of malnourished alcoholics is nutritional or a toxic condition.,,, This photo shows evidence for a nutritional cause of midline cerebellar disease.
|Figure 1: Slices of the brainstem (a) and cerebellum (b) from a dog with experimental Wernicke disease|
Click here to view
The experimental Wernicke disease was produced by the well-established method of providing a thiamine free diet and subcutaneously injecting pyrithiamine, an inhibitor of thiamine metabolism. The institutional review board approved the study and a detailed report will be forthcoming.
Financial support and sponsorship
This study was funded by the Medlantic Research Institute. The funding body has not been involved in the design of the study and collection, analysis, and interpretation of data.
Conflicts of interest
There are no conflicts of interest.
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