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 ORIGINAL ARTICLE
Year : 2022  |  Volume : 70  |  Issue : 2  |  Page : 652--659

Cerebral Venous Thrombosis in COVID-19


1 Department of Neurology, Fortis Hospital, Mulund, Maharashtra, India
2 Department of Neurology, Somaiya Superspeciality Centre, Mumbai, Maharashtra, India
3 Department of Neurology, Medihope Hospital, Kalyan, Maharashtra, India
4 Department of Neurology, Criticare Hospital and Research Centre, Mumbai, Maharashtra, India
5 Department of Neurology, Highland Superspeciality Hospital, Thane, Maharashtra, India
6 Department of Neurology, Sanjeevani Hospital, Mumbai, Maharashtra, India
7 Department of Neurology, Karuna Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Rajesh Benny
1403, Tower 6, Runwal Greens, Mulund Goregaon Link Road, Bhandup (W), Mumbai - 400 078, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.344623

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Background: COVID-19 causes a hypercoagulable state leading to thrombosis. Many of these thrombotic complications occur in those with severe disease and late in the disease course. COVID-19 has recently been associated with cerebral venous thrombosis (CVT). Objective: To study the onset of CVT in relation to COVID-19 and compare their characteristics and outcomes with non-COVID CVT patients admitted during the same period. Materials and Methods: This multicentric, retrospective study conducted between April 4 and October 15, 2020, included adult patients with CVT who were positive for the SARS-CoV-2 virus and compared them with CVT patients who were negative for the SARS-CoV-2 virus hospitalized during the same period. We studied their clinical profile, risk factors for CVT, and markers of COVID coagulopathy, imaging characteristics, and factors influencing their outcomes. Results: We included 18 COVID-19-infected patients and compared them with 43 non-COVID-19 CVT patients. Fourteen patients in the COVID-19 group presented with CVT without the other typical features of COVID-19. Thirteen patients had non-severe COVID-19 disease. Twelve patients had a good outcome (mRS ≤2). Mortality and disability outcomes were not significantly different between the two groups. Conclusion: Our study suggests a possible association between COVID-19 and CVT. CVT can be the presenting manifestation of an underlying COVID-19, occurring early in the course of COVID-19 and even in those with mild disease. Patients with worse GCS on admission, abnormal HRCT chest, severe COVID-19, and need for invasive ventilation had a poor outcome.






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