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Year : 2022  |  Volume : 70  |  Issue : 2  |  Page : 714--720

Comparison of Frozen Section and Squash Cytology as Intra-Operative Diagnostic Tool in Pediatric CNS Tumors

1 Department of Pathology, IPGME and R, Park Clinic, Kolkata, West Bengal, India
2 Department of Neurosurgery, BIN, Park Clinic, Kolkata, West Bengal, India
3 Department of Neurosurgery, Park Clinic, Kolkata, West Bengal, India

Correspondence Address:
Dr. Uttara Chatterjee
Department of Pathology, IPGME and R, 244 AJC Bose Road, Kolkata - 700 200, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.344656

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Background: Pediatric central nervous system (CNS) tumors have a different histological spectrum as compared to adults with the infantile group having even more varied and distinct histological profiles. Intra-operative diagnosis is especially important as it guides the neurosurgeon to tailor an approach which is best suited for a particular case. The aim of the study was to evaluate the diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value of frozen section (FS) and squash cytology and to find out the degree of correlation (kappa value) between the two procedures. Materials and Methods: A prospective study was conducted on 55 pediatric patients with clinicoradiologically diagnosed CNS lesions for a period of 2.5 years. Intra-operative squash smears and FS were made and stained with hematoxylin and eosin stain. Diagnosis made subsequently on paraffin embedded sections was taken as the gold standard. Results: Although the specificity (90%) and positive predictive value (96%) were comparable between the two procedures, sensitivity (91.4%) and negative predictive value (75%) of FS was more as compared to squash cytology. Both the diagnostic modalities showed substantial agreement (k = 0.728). Conclusion: Even though the histological spectrum of pediatric CNS tumors is more varied than adults, FS gives a reasonable intra-operative diagnosis and better results when compared to squash alone.


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