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Year : 2022  |  Volume : 70  |  Issue : 2  |  Page : 729--732

Genetic Polymorphisms in DRD4 and Risk for Parkinson's Disease Among Eastern Indians

1 S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, West Bengal, India
2 S. N. Pradhan Centre for Neurosciences, University of Calcutta; Molecular Biology & Clinical Neuroscience Division, National Neurosciences Centre Calcutta, Kolkata, West Bengal, India
3 Institute of Post graduate of Medical Education & Research and Bangur Institute of Neurosciences, Kolkata, West Bengal, India
4 School of Biological Sciences, RKMVERI, Narendrapur, West Bengal, India

Correspondence Address:
Dr. Ray Jharna
University of Calcutta, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.344670

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Background: Genetic factors, including causal gene and modifier genes, contribute significantly in PD pathogenesis in an ethnicity-dependent manner. Dopamine Receptor 4 (DRD4), involved in dopamine metabolism is one such modifier locus for PD. Objective: To identify the potential association of DRD4 polymorphic variants with PD among Eastern Indians. Methods and Materials: PD-related DRD4 variants were genotyped among 291 PD patients and 265 ethnically matched controls from Eastern India. Results and Conclusion: Among the three DRD4 variants, only the 120 bp duplicated allele [P = 0.036; Odds ratio: 1.323; 95% CI: 1.014–1.725] and its homozygous genotype [P = 0.034; Odds ratio: 1.452; 95% CI: 1.025–2.057] were found as risk factors for overall PD and sporadic PD among Eastern Indians. However, no other disease-associated variant or haplotype was identified. Therefore, in conclusion, our study demonstrates that DRD4 plays a small role in PD pathogenesis among Eastern Indians.


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